FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328132739> ?p ?o ?g. }

• W4328132739 abstract "Abstract Background Painful diabetic peripheral neuropathy (PDPN) is a key concern in clinical practice. In this systematic review and meta-analysis, we compared duloxetine and placebo treatments in terms of their efficacy and safety in patients with PDPN. Methods Following the PRISMA guidelines, we searched the Cochrane Library, PubMed, and Embase databases for relevant English articles published before January 11, 2021. Treatment efficacy and safety were assessed in terms of pain improvement, patient-reported health-related performance, and patients’ quality of life. Results We reviewed a total of 7 randomized controlled trials. Regarding pain improvement, duloxetine was more efficacious than placebo (mean difference [MD] − 0.89; 95% confidence interval [CI] − 1.09 to − 0.69; P < .00001). Furthermore, duloxetine significantly improved the patients’ quality of life, which was assessed using the Clinical Global Impression severity subscale (MD − 0.48; 95% CI − 0.61 to − 0.36; P < .00001), Patient Global Impression of Improvement scale (MD − 0.50; 95% CI − 0.64 to − 0.37; P < .00001), and European Quality of Life Instrument 5D version (MD 0.04; 95% CI 0.02 to 0.07; P = .0002). Severe adverse events were rare, whereas nausea, somnolence, dizziness, fatigue, constipation, and decreased appetite were common; approximately, 12.6% of all patients dropped out because of the common symptoms. Conclusions Duloxetine is more efficacious than placebo treatments in patients with PDPN. The rarity of severe adverse events indicates that duloxetine is safe. When a 60-mg dose is insufficient, 120 mg of duloxetine may improve PDPN symptoms. Our findings may help devise optimal treatment strategies for PDPN. Systematic review registration PROSPERO CRD42021225451" @default.
• W4328132739 created "2023-03-22" @default.
• W4328132739 creator A5067499480 @default.
• W4328132739 creator A5075430112 @default.
• W4328132739 creator A5076011582 @default.
• W4328132739 creator A5077008436 @default.
• W4328132739 date "2023-03-21" @default.
• W4328132739 modified "2023-09-30" @default.
• W4328132739 title "Efficacy and safety of duloxetine in painful diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials" @default.
• W4328132739 cites W1512474915 @default.
• W4328132739 cites W1539668930 @default.
• W4328132739 cites W1712756532 @default.
• W4328132739 cites W1742833546 @default.
• W4328132739 cites W1873305365 @default.
• W4328132739 cites W1984010212 @default.
• W4328132739 cites W1984259090 @default.
• W4328132739 cites W1998350079 @default.
• W4328132739 cites W200313927 @default.
• W4328132739 cites W2012561402 @default.
• W4328132739 cites W2018506852 @default.
• W4328132739 cites W2026423509 @default.
• W4328132739 cites W2029414706 @default.
• W4328132739 cites W2040163165 @default.
• W4328132739 cites W2043595892 @default.
• W4328132739 cites W2072534151 @default.
• W4328132739 cites W2081325201 @default.
• W4328132739 cites W2085316111 @default.
• W4328132739 cites W2094592334 @default.
• W4328132739 cites W2099366664 @default.
• W4328132739 cites W2102114196 @default.
• W4328132739 cites W2106059433 @default.
• W4328132739 cites W2115451671 @default.
• W4328132739 cites W2119456191 @default.
• W4328132739 cites W2125435699 @default.
• W4328132739 cites W2125761169 @default.
• W4328132739 cites W2128412489 @default.
• W4328132739 cites W2132309748 @default.
• W4328132739 cites W2135932738 @default.
• W4328132739 cites W2138407894 @default.
• W4328132739 cites W2138512124 @default.
• W4328132739 cites W2146594973 @default.
• W4328132739 cites W2160315861 @default.
• W4328132739 cites W2206489433 @default.
• W4328132739 cites W2320909684 @default.
• W4328132739 cites W2561727131 @default.
• W4328132739 cites W2600906330 @default.
• W4328132739 cites W2768362509 @default.
• W4328132739 cites W2768454515 @default.
• W4328132739 cites W2964637092 @default.
• W4328132739 cites W2970684805 @default.
• W4328132739 cites W2991792334 @default.
• W4328132739 cites W2999797667 @default.
• W4328132739 cites W3025507827 @default.
• W4328132739 cites W4226275502 @default.
• W4328132739 cites W51209413 @default.
• W4328132739 doi "https://doi.org/10.1186/s13643-023-02185-6" @default.
• W4328132739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36945033" @default.
• W4328132739 hasPublicationYear "2023" @default.
• W4328132739 type Work @default.
• W4328132739 citedByCount "1" @default.
• W4328132739 countsByYear W43281327392023 @default.
• W4328132739 crossrefType "journal-article" @default.
• W4328132739 hasAuthorship W4328132739A5067499480 @default.
• W4328132739 hasAuthorship W4328132739A5075430112 @default.
• W4328132739 hasAuthorship W4328132739A5076011582 @default.
• W4328132739 hasAuthorship W4328132739A5077008436 @default.
• W4328132739 hasBestOaLocation W43281327391 @default.
• W4328132739 hasConcept C126322002 @default.
• W4328132739 hasConcept C142724271 @default.
• W4328132739 hasConcept C159110408 @default.
• W4328132739 hasConcept C168563851 @default.
• W4328132739 hasConcept C1862650 @default.
• W4328132739 hasConcept C197934379 @default.
• W4328132739 hasConcept C204787440 @default.
• W4328132739 hasConcept C27081682 @default.
• W4328132739 hasConcept C2776468701 @default.
• W4328132739 hasConcept C2776478404 @default.
• W4328132739 hasConcept C2779951463 @default.
• W4328132739 hasConcept C2780580376 @default.
• W4328132739 hasConcept C2780764818 @default.
• W4328132739 hasConcept C2781112942 @default.
• W4328132739 hasConcept C2910564767 @default.
• W4328132739 hasConcept C42219234 @default.
• W4328132739 hasConcept C71924100 @default.
• W4328132739 hasConcept C95190672 @default.
• W4328132739 hasConceptScore W4328132739C126322002 @default.
• W4328132739 hasConceptScore W4328132739C142724271 @default.
• W4328132739 hasConceptScore W4328132739C159110408 @default.
• W4328132739 hasConceptScore W4328132739C168563851 @default.
• W4328132739 hasConceptScore W4328132739C1862650 @default.
• W4328132739 hasConceptScore W4328132739C197934379 @default.
• W4328132739 hasConceptScore W4328132739C204787440 @default.
• W4328132739 hasConceptScore W4328132739C27081682 @default.
• W4328132739 hasConceptScore W4328132739C2776468701 @default.
• W4328132739 hasConceptScore W4328132739C2776478404 @default.
• W4328132739 hasConceptScore W4328132739C2779951463 @default.
• W4328132739 hasConceptScore W4328132739C2780580376 @default.
• W4328132739 hasConceptScore W4328132739C2780764818 @default.
• W4328132739 hasConceptScore W4328132739C2781112942 @default.
• W4328132739 hasConceptScore W4328132739C2910564767 @default.

• next