Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328132860> ?p ?o ?g. }
- W4328132860 abstract "Abstract In mammals, the ability to optimize and select behavioral strategies is a cardinal and conserved psychophysiological feature for maximizing the chances of survival. However, the neural circuits and underlying mechanisms regulating this flexible feature remain yet unsolved. Here, we demonstrate that such optimization relies on dopamine D2 receptors (D2R) within a subcircuit spanning across the extended amygdala (EA) and the tail of the striatum (TS). Using a mouse model carrying a temporally controlled deletion of D2R within a subcircuit defined by WFS1 neurons, we found that intact EA D2R signaling is necessary to regulate homeostasis-dependent food-seeking behaviors in both male and female mice as well as active avoidance learning and innate escape responses in males. Altogether, these findings identify EA and TS D2R signaling as a novel hub through which dopamine optimizes appetitive behaviors and regulates the switch from passive to active defensive behaviors, regardless of learned or innate threats." @default.
- W4328132860 created "2023-03-22" @default.
- W4328132860 creator A5010860383 @default.
- W4328132860 creator A5012299131 @default.
- W4328132860 creator A5014500464 @default.
- W4328132860 creator A5015767542 @default.
- W4328132860 creator A5017149105 @default.
- W4328132860 creator A5017232022 @default.
- W4328132860 creator A5025364337 @default.
- W4328132860 creator A5025599568 @default.
- W4328132860 creator A5031661403 @default.
- W4328132860 creator A5040038645 @default.
- W4328132860 creator A5042426441 @default.
- W4328132860 creator A5047698091 @default.
- W4328132860 creator A5053594140 @default.
- W4328132860 creator A5054481859 @default.
- W4328132860 creator A5055498615 @default.
- W4328132860 creator A5065711075 @default.
- W4328132860 creator A5068903708 @default.
- W4328132860 creator A5080375606 @default.
- W4328132860 creator A5085188829 @default.
- W4328132860 date "2023-03-21" @default.
- W4328132860 modified "2023-10-01" @default.
- W4328132860 title "Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors" @default.
- W4328132860 cites W1105922843 @default.
- W4328132860 cites W1181414234 @default.
- W4328132860 cites W1556823507 @default.
- W4328132860 cites W1575308939 @default.
- W4328132860 cites W1603351184 @default.
- W4328132860 cites W1691520532 @default.
- W4328132860 cites W1886547066 @default.
- W4328132860 cites W1972227186 @default.
- W4328132860 cites W1972489844 @default.
- W4328132860 cites W1976129211 @default.
- W4328132860 cites W1976190136 @default.
- W4328132860 cites W1981044491 @default.
- W4328132860 cites W2003637435 @default.
- W4328132860 cites W2008762508 @default.
- W4328132860 cites W2009342550 @default.
- W4328132860 cites W2018346570 @default.
- W4328132860 cites W2021108986 @default.
- W4328132860 cites W2024647991 @default.
- W4328132860 cites W2025052669 @default.
- W4328132860 cites W2025469475 @default.
- W4328132860 cites W2026866239 @default.
- W4328132860 cites W2029007897 @default.
- W4328132860 cites W2043096011 @default.
- W4328132860 cites W2043884058 @default.
- W4328132860 cites W2049669528 @default.
- W4328132860 cites W2057177284 @default.
- W4328132860 cites W2060210617 @default.
- W4328132860 cites W2061559918 @default.
- W4328132860 cites W2063750361 @default.
- W4328132860 cites W2064885604 @default.
- W4328132860 cites W2064896421 @default.
- W4328132860 cites W2072021328 @default.
- W4328132860 cites W2073134122 @default.
- W4328132860 cites W2076861141 @default.
- W4328132860 cites W2078340953 @default.
- W4328132860 cites W2079491525 @default.
- W4328132860 cites W2079756607 @default.
- W4328132860 cites W2082624134 @default.
- W4328132860 cites W2085782088 @default.
- W4328132860 cites W2091209465 @default.
- W4328132860 cites W2099440512 @default.
- W4328132860 cites W2101077649 @default.
- W4328132860 cites W2102821668 @default.
- W4328132860 cites W2109059823 @default.
- W4328132860 cites W2112444367 @default.
- W4328132860 cites W2114520249 @default.
- W4328132860 cites W2116707460 @default.
- W4328132860 cites W2131785256 @default.
- W4328132860 cites W2147782024 @default.
- W4328132860 cites W2149673541 @default.
- W4328132860 cites W2150718243 @default.
- W4328132860 cites W2153436178 @default.
- W4328132860 cites W2164125772 @default.
- W4328132860 cites W2167305107 @default.
- W4328132860 cites W2168296897 @default.
- W4328132860 cites W2170041171 @default.
- W4328132860 cites W2172201406 @default.
- W4328132860 cites W2190245255 @default.
- W4328132860 cites W2215352332 @default.
- W4328132860 cites W2258752721 @default.
- W4328132860 cites W2405345309 @default.
- W4328132860 cites W2419438565 @default.
- W4328132860 cites W2534475745 @default.
- W4328132860 cites W2536660189 @default.
- W4328132860 cites W2590359509 @default.
- W4328132860 cites W2602799162 @default.
- W4328132860 cites W2605419237 @default.
- W4328132860 cites W2763129795 @default.
- W4328132860 cites W2784048367 @default.
- W4328132860 cites W2790335278 @default.
- W4328132860 cites W2792675846 @default.
- W4328132860 cites W2794576793 @default.
- W4328132860 cites W2888695486 @default.
- W4328132860 cites W2898064160 @default.
- W4328132860 cites W2901153433 @default.
- W4328132860 cites W2917268421 @default.