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• W4328132875 abstract "Circadian clocks are essential for the function of a wide array of organisms, from cyanobacteria to humans. Despite decades of productive study of these systems, mysteries remain, including why many biological clocks have non-24-hour internal periods. We take a new approach to circadian clocks by focusing on downstream readout of the clock’s state to answer physiologically relevant questions, such as ‘when will the sun rise?’ Using this framework, we show that systematic errors arising from sunrise and sunset prediction can be compensated by having non-24 hour internal periods. We show that this prediction holds in models of cyanobacterial circadian clocks. Finally, we predict latitude-dependant qualitative changes in circadian clock structure and the performance of different clock phenotypes in common laboratory experimental setups." @default.
• W4328132875 created "2023-03-22" @default.
• W4328132875 creator A5028585435 @default.
• W4328132875 creator A5083346516 @default.
• W4328132875 date "2023-03-21" @default.
• W4328132875 modified "2023-09-27" @default.
• W4328132875 title "Fast or slow? Clock readout sets internal periods" @default.
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• W4328132875 doi "https://doi.org/10.1101/2023.03.17.533212" @default.
• W4328132875 hasPublicationYear "2023" @default.
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