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• W4328134589 abstract "Abstract Angelman Syndrome (AS) is a neurodevelopmental disorder with complex symptomatology caused by the loss of maternal allele expression of one single gene in the brain, the ubiquitin E3 ligase UBE3A . The underlying genetic basis of AS, and the phenotypes observed in both humans and in animal models of AS, have previously been extensively described. However, the molecular mechanisms regulated by UBE3A ubiquitination in the brain remain highly elusive. Previous studies have reported a number of proteins whose abundance or activity are altered in AS models, implicating various signalling pathways in the physiopathology of AS. However, the identified pathways could well be altered further downstream of UBE3A ubiquitination events. We provide the first proteomic report of UBE3A-mediated ubiquitination events in a mammalian brain. For this we have combined the bioUb mouse model with a new mouse strain moderately increasing UBE3A levels. Several proteins known to be involved in the trafficking and maintenance of neurotransmitter receptors as well as proteins relaying the signals of these synaptic receptors are shown here to be ubiquitinated by UBE3A. The identified proteins have roles in higher mental function, long term potentiation, seizures and neurodevelopmental disorders, being involved in the BDNF, RAS/ERK and TSC/mTOR signalling pathways. A reduced ubiquitination of these proteins is expected when UBE3A levels are lower, so their identification could be key to opening novel therapeutic strategies for treating Angelman Syndrome. Further work will be required to characterize how UBE3A timely orchestrates each of these multiple regulatory events in different neuronal subtypes within the human brain." @default.
• W4328134589 created "2023-03-22" @default.
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• W4328134589 date "2023-03-21" @default.
• W4328134589 modified "2023-09-27" @default.
• W4328134589 title "Angelman Syndrome causing UBE3A ligase displays predominantly synaptic ubiquitination activity in the mouse brain" @default.
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• W4328134589 cites W1983532821 @default.
• W4328134589 cites W1985513877 @default.
• W4328134589 cites W1988764271 @default.
• W4328134589 cites W1990797251 @default.
• W4328134589 cites W1991101546 @default.
• W4328134589 cites W1992577657 @default.
• W4328134589 cites W1993275955 @default.
• W4328134589 cites W2008798771 @default.
• W4328134589 cites W2012393013 @default.
• W4328134589 cites W2016523902 @default.
• W4328134589 cites W2024386053 @default.
• W4328134589 cites W2030282106 @default.
• W4328134589 cites W2031746153 @default.
• W4328134589 cites W2038719756 @default.
• W4328134589 cites W2042062849 @default.
• W4328134589 cites W2055521510 @default.
• W4328134589 cites W2056986941 @default.
• W4328134589 cites W2075059777 @default.
• W4328134589 cites W2080984518 @default.
• W4328134589 cites W2089542359 @default.
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• W4328134589 cites W2099095224 @default.
• W4328134589 cites W2103805605 @default.
• W4328134589 cites W2109476749 @default.
• W4328134589 cites W2112873690 @default.
• W4328134589 cites W2137671503 @default.
• W4328134589 cites W2141466699 @default.
• W4328134589 cites W2143651812 @default.
• W4328134589 cites W2149203132 @default.
• W4328134589 cites W2149631083 @default.
• W4328134589 cites W2154703935 @default.
• W4328134589 cites W2170939558 @default.
• W4328134589 cites W2177136124 @default.
• W4328134589 cites W2184580009 @default.
• W4328134589 cites W2325470121 @default.
• W4328134589 cites W2398856305 @default.
• W4328134589 cites W2463195069 @default.
• W4328134589 cites W2472798150 @default.
• W4328134589 cites W2520154378 @default.
• W4328134589 cites W2520272104 @default.
• W4328134589 cites W2544360569 @default.
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• W4328134589 cites W2730255373 @default.
• W4328134589 cites W2737764543 @default.
• W4328134589 cites W2753903547 @default.
• W4328134589 cites W2785201697 @default.
• W4328134589 cites W2791098185 @default.
• W4328134589 cites W2793610094 @default.
• W4328134589 cites W2797870096 @default.
• W4328134589 cites W2799716780 @default.
• W4328134589 cites W2809763569 @default.
• W4328134589 cites W2896691015 @default.
• W4328134589 cites W2898137459 @default.
• W4328134589 cites W2927034536 @default.
• W4328134589 cites W2942905555 @default.
• W4328134589 cites W2944545583 @default.
• W4328134589 cites W2950649593 @default.
• W4328134589 cites W2980676468 @default.
• W4328134589 cites W2985169208 @default.
• W4328134589 cites W3008711268 @default.
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• W4328134589 cites W3131931478 @default.
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• W4328134589 cites W3178500894 @default.
• W4328134589 cites W3192696049 @default.
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• W4328134589 cites W3208691473 @default.
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• W4328134589 doi "https://doi.org/10.21203/rs.3.rs-2665803/v1" @default.
• W4328134589 hasPublicationYear "2023" @default.
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