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• W4328135923 endingPage "34" @default.
• W4328135923 startingPage "24" @default.
• W4328135923 abstract "Fatty acids (FAs) play important roles in cell membrane structure maintenance, energy production via β-oxidation, and as extracellular signaling molecules. Prior studies have demonstrated that exposure of cancer cells to FAs affects cell survival, cell proliferation, and cell motility. Oleic acid (OA) has somewhat controversial effects in cancer cells, with both pro- and anti-cancer effects, depending on cell type. Our prior findings suggested that OA enhances cell survival in serum starved HNOA ovarian cancer cells by activating glycolysis, but not β-oxidation. Here, we pharmacologically examined the cellular mechanisms by which OA stimulates glycolysis in HNOA cells. OA induced cell cycle progression, leading to increase in cell number through peroxisome proliferator activated receptor (PPAR) α activation. OA-induced glycolysis was mediated by increased GLUT expression, and increases in GLUT expression were mediated by increased L-MYC expression. Furthermore, L-MYC expression was due to BRD4 activation. These findings suggested involvement of the BRD4-L-MYC-GLUT axis in OA-stimulated glycolysis. These results suggested that OA could activate PPARα to stimulate two pathways: glycolysis and cell cycle progression, and provided insight into the role of OA in ovarian cancer cell growth." @default.
• W4328135923 created "2023-03-22" @default.
• W4328135923 creator A5010201351 @default.
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• W4328135923 date "2023-05-01" @default.
• W4328135923 modified "2023-09-27" @default.
• W4328135923 title "Oleic acid stimulates cell proliferation and BRD4–L-MYC-dependent glucose transporter transcription through PPARα activation in ovarian cancer cells" @default.
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• W4328135923 doi "https://doi.org/10.1016/j.bbrc.2023.03.051" @default.
• W4328135923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36965420" @default.
• W4328135923 hasPublicationYear "2023" @default.
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