FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328136070> ?p ?o ?g. }

• W4328136070 endingPage "109512" @default.
• W4328136070 startingPage "109512" @default.
• W4328136070 abstract "The current opioid epidemic is a national health crisis marked by skyrocketing reports of opioid misuse and overdose deaths. Despite the risks involved, prescription opioid analgesics are the most powerful and effective medications for treating pain. There is a clear need to investigate the risk of opioid misuse liability in male and female adults experiencing chronic pain. In the present study, we tested the hypothesis that chronic inflammatory pain would increase fentanyl intake, motivation to acquire fentanyl, and drug seeking in the absence of fentanyl in rats. Fentanyl intake, motivation for fentanyl, and drug seeking were tested under limited and extended access conditions using intravenous fentanyl self-administration. Fos activity in ventral tegmental area (VTA) dopamine neurons following intravenous fentanyl challenge (35 μg/kg) was examined using immunohistochemistry. Finally, we tested whether low-dose fentanyl supports development of conditioned place preference under an inflammatory pain state in rats. Contrary to our hypothesis, fentanyl self-administration and VTA Fos activity were unaffected by inflammatory pain status. During acquisition, males exhibited increased fentanyl intake compared to females. Animals given extended access to fentanyl escalated fentanyl intake over time, while animals given limited access did not. Males given extended access to fentanyl demonstrated a greater increase in fentanyl intake over time compared to females. During the dose-response test, females given limited access to fentanyl demonstrated increased motivation to acquire fentanyl compared to males. Both sexes displayed significant increases in responding for fentanyl as unit fentanyl doses were lowered. Following fentanyl challenge, females exhibited higher numbers of Fos-positive non-dopaminergic VTA neurons compared to males. Using conditioned place preference, we found that chronic inflammatory pain promotes fentanyl preference in males, but not females. These findings suggest that established fentanyl self-administration is resistant to change by inflammatory pain manipulation in both sexes, but chronic inflammatory pain increases the rewarding properties of low-dose fentanyl in males." @default.
• W4328136070 created "2023-03-22" @default.
• W4328136070 creator A5005496884 @default.
• W4328136070 creator A5005576211 @default.
• W4328136070 creator A5017302106 @default.
• W4328136070 creator A5043734937 @default.
• W4328136070 creator A5046335360 @default.
• W4328136070 creator A5079595425 @default.
• W4328136070 date "2023-06-01" @default.
• W4328136070 modified "2023-10-09" @default.
• W4328136070 title "Chronic inflammatory pain promotes place preference for fentanyl in male rats but does not change fentanyl self-administration in male and female rats" @default.
• W4328136070 cites W114451446 @default.
• W4328136070 cites W1520279806 @default.
• W4328136070 cites W1822002712 @default.
• W4328136070 cites W1831515958 @default.
• W4328136070 cites W1838797258 @default.
• W4328136070 cites W1891678001 @default.
• W4328136070 cites W1965999023 @default.
• W4328136070 cites W1970226919 @default.
• W4328136070 cites W1982683778 @default.
• W4328136070 cites W1983987741 @default.
• W4328136070 cites W1989362268 @default.
• W4328136070 cites W2000929822 @default.
• W4328136070 cites W2001352609 @default.
• W4328136070 cites W2015092441 @default.
• W4328136070 cites W2017462460 @default.
• W4328136070 cites W2025968814 @default.
• W4328136070 cites W2030195620 @default.
• W4328136070 cites W2053216532 @default.
• W4328136070 cites W2057758856 @default.
• W4328136070 cites W2070078848 @default.
• W4328136070 cites W2074010882 @default.
• W4328136070 cites W2087657646 @default.
• W4328136070 cites W2088239718 @default.
• W4328136070 cites W2100405437 @default.
• W4328136070 cites W2112352316 @default.
• W4328136070 cites W2115602937 @default.
• W4328136070 cites W2124427850 @default.
• W4328136070 cites W2134330719 @default.
• W4328136070 cites W2140480452 @default.
• W4328136070 cites W2151383246 @default.
• W4328136070 cites W2154798479 @default.
• W4328136070 cites W2163756981 @default.
• W4328136070 cites W2257819777 @default.
• W4328136070 cites W2283922892 @default.
• W4328136070 cites W2296986887 @default.
• W4328136070 cites W2312104423 @default.
• W4328136070 cites W2318353764 @default.
• W4328136070 cites W2469419628 @default.
• W4328136070 cites W2569240731 @default.
• W4328136070 cites W2581194516 @default.
• W4328136070 cites W2587222353 @default.
• W4328136070 cites W2763381932 @default.
• W4328136070 cites W2790175340 @default.
• W4328136070 cites W2793706579 @default.
• W4328136070 cites W2806465603 @default.
• W4328136070 cites W2891660975 @default.
• W4328136070 cites W2914014906 @default.
• W4328136070 cites W2914174171 @default.
• W4328136070 cites W2922068945 @default.
• W4328136070 cites W2959524766 @default.
• W4328136070 cites W2977763422 @default.
• W4328136070 cites W2982734907 @default.
• W4328136070 cites W2997883126 @default.
• W4328136070 cites W3007809178 @default.
• W4328136070 cites W3012446951 @default.
• W4328136070 cites W3093227095 @default.
• W4328136070 cites W3097297564 @default.
• W4328136070 cites W3097837046 @default.
• W4328136070 cites W3118140448 @default.
• W4328136070 cites W3119141034 @default.
• W4328136070 cites W3119685613 @default.
• W4328136070 cites W3120128985 @default.
• W4328136070 cites W3120673073 @default.
• W4328136070 cites W3126315695 @default.
• W4328136070 cites W3130626664 @default.
• W4328136070 cites W3159863606 @default.
• W4328136070 cites W3164545166 @default.
• W4328136070 cites W3164876229 @default.
• W4328136070 cites W3174840358 @default.
• W4328136070 cites W3202968215 @default.
• W4328136070 cites W4207061874 @default.
• W4328136070 cites W4220886182 @default.
• W4328136070 cites W4221085837 @default.
• W4328136070 doi "https://doi.org/10.1016/j.neuropharm.2023.109512" @default.
• W4328136070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36948356" @default.
• W4328136070 hasPublicationYear "2023" @default.
• W4328136070 type Work @default.
• W4328136070 citedByCount "2" @default.
• W4328136070 countsByYear W43281360702023 @default.
• W4328136070 crossrefType "journal-article" @default.
• W4328136070 hasAuthorship W4328136070A5005496884 @default.
• W4328136070 hasAuthorship W4328136070A5005576211 @default.
• W4328136070 hasAuthorship W4328136070A5017302106 @default.
• W4328136070 hasAuthorship W4328136070A5043734937 @default.
• W4328136070 hasAuthorship W4328136070A5046335360 @default.
• W4328136070 hasAuthorship W4328136070A5079595425 @default.
• W4328136070 hasConcept C126322002 @default.

• next