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• W4328136072 endingPage "142522" @default.
• W4328136072 startingPage "142522" @default.
• W4328136072 abstract "Undesirable exposures to the nuclear radiation will inevitably cause risks to human health, and may result in carcinogenesis, organ failure and cell mutations. It is a long-standing and urgent challenge to establish a new radiation therapy systems so as to timely reduce the radiation injury. Stimuli-responsive drug delivery systems are powerful and useful for disease treatment over the past two decades and has a profound interdisciplinary effect on scientific research. Compared with traditional radiation injury treatment strategies, recently, radiation stimuli-responsive drug delivery systems have been attracting growing interest due to their timely response and excellent efficacy. When the intelligent response carrier materials are irradiated by a specific dose of radiation, the polymer chain is broken, resulting in degradation so as to quickly release the therapeutic drug and timely treat the injury. Importantly, with emergence of a new strategy and mechanism of the injury treatment (for example, polymer radioprotectors via a multi-component reaction), a comprehensive review on gamma-ray responsive controlled-release drug delivery system with emphasis on advancements in recent years remains lacking. Issues regarding radiation injury, treatment mechanism, stimulus response-controlled release, and future prospects are discussed. This review focuses on the state-of-art of radiation therapy systems and introduces the gamma-ray responsive controlled-release drug delivery system. Furthermore, the application of the radiation stimuli-responsive drug delivery systems encapsulated by different organic matrix materials as composite materials is also reviewed. A general and substantial review looking at all aspects of the radiation injury from the principle of radiation damage to the specific application of controlled-release drug system would be of profound impact on this emerging, active, and pivotal field." @default.
• W4328136072 created "2023-03-22" @default.
• W4328136072 creator A5039715758 @default.
• W4328136072 creator A5060771633 @default.
• W4328136072 creator A5068795956 @default.
• W4328136072 creator A5075939587 @default.
• W4328136072 date "2023-05-01" @default.
• W4328136072 modified "2023-09-27" @default.
• W4328136072 title "Gamma-ray-responsive drug delivery systems for radiation protection" @default.
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