Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328136074> ?p ?o ?g. }
- W4328136074 endingPage "124088" @default.
- W4328136074 startingPage "124088" @default.
- W4328136074 abstract "Polydopamine nanoparticles (PDA NPs) are commonly used for photothermal therapy (PTT) of cancer because of their good biocompatibility and photothermal conversion capability. However, it is difficult to achieve a good tumor inhibition effect with a single PTT of PDA. Therefore, in this work, we prepared a combined anticancer nanosystem for enhanced chemodynamic therapy (CDT)/PTT by coating PDAs with an (-)-epigallocatechin gallate (EGCG)/iron (Fe) metal-polyphenol network (MPN). The MPN shell of this nanosystem named EGCG@PDA is degraded by the weakly acidic environment intracellular, releasing EGCG and Fe3+. EGCG inhibits the expression of heat shock proteins (HSPs) in cancer cells, thus eliminating their thermal protection against cancer cells for enhanced PTT. Meanwhile, the reductive EGCG can also reduce Fe3+ to Fe2+, to catalyze the decomposition of overexpressed hydrogen peroxide (H2O2) in cancer cells to generate strong oxidative hydroxyl radicals (OH), i.e., catalyzing the Fenton reaction, for CDT. After the Fenton reaction, the re-oxidized Fe ions can be reduced again by EGCG and reused to catalyze the Fenton reaction, which can achieve enhanced CDT. Both in vitro and in vivo studies have shown that EGCG@PDA has low dark toxicity and good anticancer effects. It is expected to be used for precision cancer therapy." @default.
- W4328136074 created "2023-03-22" @default.
- W4328136074 creator A5022332733 @default.
- W4328136074 creator A5024699320 @default.
- W4328136074 creator A5031381711 @default.
- W4328136074 creator A5033875227 @default.
- W4328136074 creator A5045699503 @default.
- W4328136074 creator A5053956165 @default.
- W4328136074 creator A5060859362 @default.
- W4328136074 creator A5084106371 @default.
- W4328136074 creator A5084573070 @default.
- W4328136074 creator A5090543342 @default.
- W4328136074 date "2023-05-01" @default.
- W4328136074 modified "2023-10-14" @default.
- W4328136074 title "Polydopamine nanoparticles coated with a metal-polyphenol network for enhanced photothermal/chemodynamic cancer combination therapy" @default.
- W4328136074 cites W1989857186 @default.
- W4328136074 cites W1994023367 @default.
- W4328136074 cites W2000419357 @default.
- W4328136074 cites W2010305557 @default.
- W4328136074 cites W2013470095 @default.
- W4328136074 cites W2035025753 @default.
- W4328136074 cites W2149124299 @default.
- W4328136074 cites W2229268188 @default.
- W4328136074 cites W2744173175 @default.
- W4328136074 cites W2895512690 @default.
- W4328136074 cites W2905522695 @default.
- W4328136074 cites W2935491511 @default.
- W4328136074 cites W2995423159 @default.
- W4328136074 cites W3016690131 @default.
- W4328136074 cites W3021994425 @default.
- W4328136074 cites W3043521173 @default.
- W4328136074 cites W3048679409 @default.
- W4328136074 cites W3093534681 @default.
- W4328136074 cites W3097057198 @default.
- W4328136074 cites W3109746568 @default.
- W4328136074 cites W3134254717 @default.
- W4328136074 cites W3140622642 @default.
- W4328136074 cites W3161723460 @default.
- W4328136074 cites W3168551284 @default.
- W4328136074 cites W3173406034 @default.
- W4328136074 cites W3175419184 @default.
- W4328136074 cites W3178291980 @default.
- W4328136074 cites W3183788670 @default.
- W4328136074 cites W3191658494 @default.
- W4328136074 cites W3197821249 @default.
- W4328136074 cites W3204360553 @default.
- W4328136074 cites W3210462008 @default.
- W4328136074 cites W3211895768 @default.
- W4328136074 cites W4200099034 @default.
- W4328136074 cites W4200372324 @default.
- W4328136074 cites W4206337389 @default.
- W4328136074 cites W4206718515 @default.
- W4328136074 cites W4212872852 @default.
- W4328136074 cites W4220660335 @default.
- W4328136074 cites W4220847494 @default.
- W4328136074 cites W4220959307 @default.
- W4328136074 cites W4285012964 @default.
- W4328136074 cites W4288886123 @default.
- W4328136074 cites W4296905216 @default.
- W4328136074 cites W4312140652 @default.
- W4328136074 doi "https://doi.org/10.1016/j.ijbiomac.2023.124088" @default.
- W4328136074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36948332" @default.
- W4328136074 hasPublicationYear "2023" @default.
- W4328136074 type Work @default.
- W4328136074 citedByCount "2" @default.
- W4328136074 countsByYear W43281360742023 @default.
- W4328136074 crossrefType "journal-article" @default.
- W4328136074 hasAuthorship W4328136074A5022332733 @default.
- W4328136074 hasAuthorship W4328136074A5024699320 @default.
- W4328136074 hasAuthorship W4328136074A5031381711 @default.
- W4328136074 hasAuthorship W4328136074A5033875227 @default.
- W4328136074 hasAuthorship W4328136074A5045699503 @default.
- W4328136074 hasAuthorship W4328136074A5053956165 @default.
- W4328136074 hasAuthorship W4328136074A5060859362 @default.
- W4328136074 hasAuthorship W4328136074A5084106371 @default.
- W4328136074 hasAuthorship W4328136074A5084573070 @default.
- W4328136074 hasAuthorship W4328136074A5090543342 @default.
- W4328136074 hasConcept C121608353 @default.
- W4328136074 hasConcept C12554922 @default.
- W4328136074 hasConcept C126322002 @default.
- W4328136074 hasConcept C139066938 @default.
- W4328136074 hasConcept C13965031 @default.
- W4328136074 hasConcept C150903083 @default.
- W4328136074 hasConcept C155672457 @default.
- W4328136074 hasConcept C171250308 @default.
- W4328136074 hasConcept C178790620 @default.
- W4328136074 hasConcept C182606246 @default.
- W4328136074 hasConcept C185592680 @default.
- W4328136074 hasConcept C192562407 @default.
- W4328136074 hasConcept C202751555 @default.
- W4328136074 hasConcept C207001950 @default.
- W4328136074 hasConcept C21951064 @default.
- W4328136074 hasConcept C2776778087 @default.
- W4328136074 hasConcept C2777230088 @default.
- W4328136074 hasConcept C2780295536 @default.
- W4328136074 hasConcept C2993040405 @default.
- W4328136074 hasConcept C48349386 @default.
- W4328136074 hasConcept C533411734 @default.