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• W4328136559 abstract "Tamoxifen as an antiestrogen is successfully applied for the clinical treatment of breast cancer in pre- and post-menopausal women. Due to the side effects related to the oral administration of Tamoxifen (such as deep vein thrombosis, pulmonary embolism, hot flushes, ocular disturbances and some types of cancer), liposomal drug delivery is recommended for taking this drug. Drug encapsulation in a liposomal or lipid drug delivery system improves the pharmacokinetic and pharmacodynamic properties. In this regard, we carried out 200-ns molecular dynamics (MD) simulations for three systems (pure DPPC and neutral and protonated Tamoxifen-loaded DPPC). Here, DPPC is a model lipid bilayer to provide us with conditions like liposomal drug delivery systems to investigate the interactions between Tamoxifen and DPPC lipid bilayers and to estimate the preferred location and orientation of the drug molecule inside the bilayer membrane. Properties such as area per lipid, membrane thickness, lateral diffusion coefficient, order parameters and mass density, were surveyed. With insertion of neutral and protonated Tamoxifen inside the DPPC lipid bilayers, area per lipid and membrane thickness increased slightly. Also, Tamoxifen induce ordering of the hydrocarbon chains in DPPC bilayer. Analysis of MD trajectories shows that neutral Tamoxifen is predominantly found in the hydrophobic tail region, whereas protonated Tamoxifen is located at the lipid-water interface (polar region of DPPC lipid bilayers)." @default.
• W4328136559 created "2023-03-22" @default.
• W4328136559 creator A5039667528 @default.
• W4328136559 date "2023-06-01" @default.
• W4328136559 modified "2023-10-16" @default.
• W4328136559 title "Interaction of neutral and protonated Tamoxifen with the DPPC lipid bilayer using molecular dynamics simulation" @default.
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• W4328136559 doi "https://doi.org/10.1016/j.steroids.2023.109225" @default.
• W4328136559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36948347" @default.
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