FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328137118> ?p ?o ?g. }

• W4328137118 endingPage "300" @default.
• W4328137118 startingPage "288" @default.
• W4328137118 abstract "Fine particulate matter (PM2.5) exposure is associated with cardiovascular disease (CVD) morbidity and mortality. Mitochondria are sensitive targets of PM2.5, and mitochondrial dysfunction is closely related to the occurrence of CVD. The epigenetic mechanism of PM2.5-triggered mitochondrial injury of cardiomyocytes is unclear. This study focused on the miR-421/SIRT3 signaling pathway to investigate the regulatory mechanism in cardiac mitochondrial dynamics imbalance in rat H9c2 cells induced by PM2.5. Results illustrated that PM2.5 impaired mitochondrial function and caused dynamics homeostasis imbalance. Besides, PM2.5 up-regulated miR-421 and down-regulated SIRT3 gene expression, along with decreasing p-FOXO3a (SIRT3 downstream target gene) and p-Parkin expression and triggering abnormal expression of fusion gene OPA1 and fission gene Drp1. Further, miR-421 inhibitor (miR-421i) and resveratrol significantly elevated the SIRT3 levels in H9c2 cells after PM2.5 exposure and mediated the expression of SOD2, OPA1 and Drp1, restoring the mitochondrial morphology and function. It suggests that miR-421/SIRT3 pathway plays an epigenetic regulatory role in mitochondrial damage induced by PM2.5 and that miR-421i and resveratrol exert protective effects against PM2.5-incurred cardiotoxicity." @default.
• W4328137118 created "2023-03-22" @default.
• W4328137118 creator A5034205421 @default.
• W4328137118 creator A5055784337 @default.
• W4328137118 creator A5061579277 @default.
• W4328137118 creator A5076434951 @default.
• W4328137118 creator A5078866844 @default.
• W4328137118 creator A5085415564 @default.
• W4328137118 date "2024-04-01" @default.
• W4328137118 modified "2023-10-16" @default.
• W4328137118 title "Regulation of PM2.5 on mitochondrial damage in H9c2 cells through miR-421/SIRT3 pathway and protective effect of miR-421 inhibitor and resveratrol" @default.
• W4328137118 cites W1514797367 @default.
• W4328137118 cites W1956607899 @default.
• W4328137118 cites W1978900120 @default.
• W4328137118 cites W1984988173 @default.
• W4328137118 cites W1985119207 @default.
• W4328137118 cites W1999835234 @default.
• W4328137118 cites W2018204941 @default.
• W4328137118 cites W2050904991 @default.
• W4328137118 cites W2055208928 @default.
• W4328137118 cites W2064080426 @default.
• W4328137118 cites W2079761894 @default.
• W4328137118 cites W2085335902 @default.
• W4328137118 cites W2099837354 @default.
• W4328137118 cites W2104412320 @default.
• W4328137118 cites W2106997728 @default.
• W4328137118 cites W2109816159 @default.
• W4328137118 cites W2110795504 @default.
• W4328137118 cites W2122341467 @default.
• W4328137118 cites W2128956618 @default.
• W4328137118 cites W2150751323 @default.
• W4328137118 cites W2152674951 @default.
• W4328137118 cites W2153127208 @default.
• W4328137118 cites W2162401872 @default.
• W4328137118 cites W2163051782 @default.
• W4328137118 cites W2320530511 @default.
• W4328137118 cites W2346277053 @default.
• W4328137118 cites W2474626525 @default.
• W4328137118 cites W2580028082 @default.
• W4328137118 cites W2768819647 @default.
• W4328137118 cites W2773436899 @default.
• W4328137118 cites W2774012631 @default.
• W4328137118 cites W2792201621 @default.
• W4328137118 cites W2793885581 @default.
• W4328137118 cites W2900582775 @default.
• W4328137118 cites W2901162259 @default.
• W4328137118 cites W2912280069 @default.
• W4328137118 cites W2953241523 @default.
• W4328137118 cites W2962232058 @default.
• W4328137118 cites W2966380363 @default.
• W4328137118 cites W2970897562 @default.
• W4328137118 cites W2988497261 @default.
• W4328137118 cites W2991518511 @default.
• W4328137118 cites W2991624599 @default.
• W4328137118 cites W3042973453 @default.
• W4328137118 cites W3085263834 @default.
• W4328137118 cites W4297093795 @default.
• W4328137118 cites W4303983678 @default.
• W4328137118 doi "https://doi.org/10.1016/j.jes.2023.03.016" @default.
• W4328137118 hasPublicationYear "2024" @default.
• W4328137118 type Work @default.
• W4328137118 citedByCount "0" @default.
• W4328137118 crossrefType "journal-article" @default.
• W4328137118 hasAuthorship W4328137118A5034205421 @default.
• W4328137118 hasAuthorship W4328137118A5055784337 @default.
• W4328137118 hasAuthorship W4328137118A5061579277 @default.
• W4328137118 hasAuthorship W4328137118A5076434951 @default.
• W4328137118 hasAuthorship W4328137118A5078866844 @default.
• W4328137118 hasAuthorship W4328137118A5085415564 @default.
• W4328137118 hasConcept C104317684 @default.
• W4328137118 hasConcept C119157956 @default.
• W4328137118 hasConcept C134018914 @default.
• W4328137118 hasConcept C138488276 @default.
• W4328137118 hasConcept C163950672 @default.
• W4328137118 hasConcept C17619807 @default.
• W4328137118 hasConcept C24586158 @default.
• W4328137118 hasConcept C2775838275 @default.
• W4328137118 hasConcept C2776108821 @default.
• W4328137118 hasConcept C2776151105 @default.
• W4328137118 hasConcept C2776816829 @default.
• W4328137118 hasConcept C2780561631 @default.
• W4328137118 hasConcept C28859421 @default.
• W4328137118 hasConcept C41091548 @default.
• W4328137118 hasConcept C54355233 @default.
• W4328137118 hasConcept C86803240 @default.
• W4328137118 hasConcept C95444343 @default.
• W4328137118 hasConcept C98274493 @default.
• W4328137118 hasConceptScore W4328137118C104317684 @default.
• W4328137118 hasConceptScore W4328137118C119157956 @default.
• W4328137118 hasConceptScore W4328137118C134018914 @default.
• W4328137118 hasConceptScore W4328137118C138488276 @default.
• W4328137118 hasConceptScore W4328137118C163950672 @default.
• W4328137118 hasConceptScore W4328137118C17619807 @default.
• W4328137118 hasConceptScore W4328137118C24586158 @default.
• W4328137118 hasConceptScore W4328137118C2775838275 @default.
• W4328137118 hasConceptScore W4328137118C2776108821 @default.
• W4328137118 hasConceptScore W4328137118C2776151105 @default.
• W4328137118 hasConceptScore W4328137118C2776816829 @default.

• next