FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328137119> ?p ?o ?g. }

• W4328137119 endingPage "106739" @default.
• W4328137119 startingPage "106739" @default.
• W4328137119 abstract "Nearly half of all Asian non-small cell lung cancer (NSCLC) patients harbour epidermal growth factor receptor (EGFR) mutations, and first-generation EGFR tyrosine kinase inhibitors (TKIs) are one of the first-line treatments that have improved the outcomes of these patients. Unfortunately, 20% of these patients can not benefit from the treatment. The basis of this primary resistance is poorly understood. Therefore, overcoming EGFR-TKI primary resistance and maintaining the efficacy of TKIs has become a key issue. β-Elemene, a sesquiterpene compound extracted from Curcuma aromatica Salisb. (wenyujing), has shown potent antitumor effects. In this research, we found that β-elemene combined with erlotinib enhanced the cytotoxicity of erlotinib to primary EGFR-TKI-resistant NSCLC cells with EGFR mutations and that ferroptosis was involved in the antitumor effect of the combination treatment. We found that lncRNA H19 was significantly downregulated in primary EGFR-TKI-resistant NSCLC cell lines and was upregulated by the combination treatment. Overexpression or knockdown of H19 conferred sensitivity or resistance to erlotinib, respectively, in both in vitro and in vivo studies. The high level of H19 enhanced the cytotoxicity of erlotinib by inducing ferroptosis. In conclusion, our data showed that β-elemene combined with erlotinib could enhance sensitivity to EGFR-TKIs through induction of ferroptosis via H19 in primary EGFR-TKI-resistant lung cancer, providing a promising strategy to overcome EGFR-TKI resistance in NSCLC patients." @default.
• W4328137119 created "2023-03-22" @default.
• W4328137119 creator A5005355217 @default.
• W4328137119 creator A5015970814 @default.
• W4328137119 creator A5018785079 @default.
• W4328137119 creator A5020082214 @default.
• W4328137119 creator A5021570234 @default.
• W4328137119 creator A5032508435 @default.
• W4328137119 creator A5032881192 @default.
• W4328137119 creator A5037677450 @default.
• W4328137119 creator A5040940901 @default.
• W4328137119 creator A5042284852 @default.
• W4328137119 creator A5046978138 @default.
• W4328137119 creator A5050509315 @default.
• W4328137119 creator A5063099790 @default.
• W4328137119 creator A5066590728 @default.
• W4328137119 creator A5068354480 @default.
• W4328137119 creator A5070442289 @default.
• W4328137119 creator A5076036593 @default.
• W4328137119 creator A5078753498 @default.
• W4328137119 creator A5087136994 @default.
• W4328137119 date "2023-05-01" @default.
• W4328137119 modified "2023-10-18" @default.
• W4328137119 title "β-Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancer" @default.
• W4328137119 cites W1619850371 @default.
• W4328137119 cites W1983774108 @default.
• W4328137119 cites W2002490399 @default.
• W4328137119 cites W2007506240 @default.
• W4328137119 cites W2067107606 @default.
• W4328137119 cites W2077848542 @default.
• W4328137119 cites W2130543801 @default.
• W4328137119 cites W2160982674 @default.
• W4328137119 cites W2331264401 @default.
• W4328137119 cites W2549987822 @default.
• W4328137119 cites W2558119126 @default.
• W4328137119 cites W2578321666 @default.
• W4328137119 cites W2594462802 @default.
• W4328137119 cites W2594499121 @default.
• W4328137119 cites W2603374842 @default.
• W4328137119 cites W2749918768 @default.
• W4328137119 cites W2761645877 @default.
• W4328137119 cites W2762087180 @default.
• W4328137119 cites W2767055857 @default.
• W4328137119 cites W2769793622 @default.
• W4328137119 cites W2770850847 @default.
• W4328137119 cites W2792821195 @default.
• W4328137119 cites W2794902297 @default.
• W4328137119 cites W2795708883 @default.
• W4328137119 cites W2802365483 @default.
• W4328137119 cites W2811011079 @default.
• W4328137119 cites W2888297236 @default.
• W4328137119 cites W2899008658 @default.
• W4328137119 cites W2901265038 @default.
• W4328137119 cites W2932111434 @default.
• W4328137119 cites W2935369648 @default.
• W4328137119 cites W2945161487 @default.
• W4328137119 cites W2980472864 @default.
• W4328137119 cites W2981179816 @default.
• W4328137119 cites W3006146649 @default.
• W4328137119 cites W3012295934 @default.
• W4328137119 cites W3015867608 @default.
• W4328137119 cites W3026882918 @default.
• W4328137119 cites W3088618559 @default.
• W4328137119 cites W3137137644 @default.
• W4328137119 cites W3162306949 @default.
• W4328137119 cites W3184797042 @default.
• W4328137119 cites W3196241423 @default.
• W4328137119 cites W3210418020 @default.
• W4328137119 cites W3215721622 @default.
• W4328137119 cites W3216855756 @default.
• W4328137119 cites W4206841660 @default.
• W4328137119 cites W4224245159 @default.
• W4328137119 cites W4243957837 @default.
• W4328137119 cites W4281673895 @default.
• W4328137119 cites W4283752588 @default.
• W4328137119 cites W4308958733 @default.
• W4328137119 doi "https://doi.org/10.1016/j.phrs.2023.106739" @default.
• W4328137119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36948327" @default.
• W4328137119 hasPublicationYear "2023" @default.
• W4328137119 type Work @default.
• W4328137119 citedByCount "7" @default.
• W4328137119 countsByYear W43281371192023 @default.
• W4328137119 crossrefType "journal-article" @default.
• W4328137119 hasAuthorship W4328137119A5005355217 @default.
• W4328137119 hasAuthorship W4328137119A5015970814 @default.
• W4328137119 hasAuthorship W4328137119A5018785079 @default.
• W4328137119 hasAuthorship W4328137119A5020082214 @default.
• W4328137119 hasAuthorship W4328137119A5021570234 @default.
• W4328137119 hasAuthorship W4328137119A5032508435 @default.
• W4328137119 hasAuthorship W4328137119A5032881192 @default.
• W4328137119 hasAuthorship W4328137119A5037677450 @default.
• W4328137119 hasAuthorship W4328137119A5040940901 @default.
• W4328137119 hasAuthorship W4328137119A5042284852 @default.
• W4328137119 hasAuthorship W4328137119A5046978138 @default.
• W4328137119 hasAuthorship W4328137119A5050509315 @default.
• W4328137119 hasAuthorship W4328137119A5063099790 @default.
• W4328137119 hasAuthorship W4328137119A5066590728 @default.
• W4328137119 hasAuthorship W4328137119A5068354480 @default.

• next