FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328137128> ?p ?o ?g. }

• W4328137128 endingPage "109294" @default.
• W4328137128 startingPage "109294" @default.
• W4328137128 abstract "Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disorder that severely impairs lung function, by increasing lung stiffness. Sesamol, a phenolic Phyto-molecule isolated from sesame seeds, possess a rich source of protein and is known to have extensive nutritional and health effects. Here we investigated the effect of sesamol on TGF-β/periostin-induced fibroblast differentiation in in vitro and bleomycin-induced pulmonary fibrosis in an in vivo model. Our results demonstrated that activation of (DHLF, LL29, NHLF and A549) cells with TGF-β, elevates the epithelial to mesenchymal transition, extracellular matrix, and collagen deposition and periostin signaling marker's expression, further treatment with sesamol attenuated these markers significantly. In addition, sesamol treatment improved the TGF-β-induced contraction and migration of cells. Mechanistic studies showed that activation of IPF cells with periostin increased the TGF-β signaling and treatment with sesamol significantly abrogated the periostin-induced TGF-β activation and its downstream fibrotic marker's expression. In in vivo, sesamol treatment attenuated the lung inflammation, infiltration of cells, wall thickening and the formation of fibrous bands significantly in BLM-induced fibrosis rats. Molecular studies revealed that sesamol treatment reduced the bleomycin-induced fibrotic, inflammatory, apoptotic marker's expression by modulating the TGF-β/periostin crosstalk signaling in a dose-dependent manner. Further, treatment with sesamol dramatically improved lung function and decreased mortality. Our study first time reports the sesamol's inhibitory effects on periostin signalling. Collectively, our study demonstrated that periostin and TGF-β seem to work in a positive-feedback loop, inducing the other, therefore, targeting TGF-β/periostin signaling may provide a better therapeutic approach against IPF and other fibrotic disorders." @default.
• W4328137128 created "2023-03-22" @default.
• W4328137128 creator A5016450118 @default.
• W4328137128 creator A5049280812 @default.
• W4328137128 creator A5056555947 @default.
• W4328137128 creator A5075729887 @default.
• W4328137128 date "2023-06-01" @default.
• W4328137128 modified "2023-09-29" @default.
• W4328137128 title "Targeting TGF-β/periostin signaling by sesamol ameliorates pulmonary fibrosis and improves lung function and survival" @default.
• W4328137128 cites W1215049722 @default.
• W4328137128 cites W1499343810 @default.
• W4328137128 cites W1969170720 @default.
• W4328137128 cites W1969900986 @default.
• W4328137128 cites W1973621813 @default.
• W4328137128 cites W1980209143 @default.
• W4328137128 cites W1981782394 @default.
• W4328137128 cites W1987990938 @default.
• W4328137128 cites W1989352859 @default.
• W4328137128 cites W2001518113 @default.
• W4328137128 cites W2006118136 @default.
• W4328137128 cites W2014187911 @default.
• W4328137128 cites W2024447823 @default.
• W4328137128 cites W2025190499 @default.
• W4328137128 cites W2041125186 @default.
• W4328137128 cites W2053142650 @default.
• W4328137128 cites W2064307892 @default.
• W4328137128 cites W2070054912 @default.
• W4328137128 cites W2075400164 @default.
• W4328137128 cites W2078995879 @default.
• W4328137128 cites W2086698890 @default.
• W4328137128 cites W2095715691 @default.
• W4328137128 cites W2096879602 @default.
• W4328137128 cites W2097732812 @default.
• W4328137128 cites W2097862336 @default.
• W4328137128 cites W2103480365 @default.
• W4328137128 cites W2111771582 @default.
• W4328137128 cites W2121453721 @default.
• W4328137128 cites W2146225176 @default.
• W4328137128 cites W2510319197 @default.
• W4328137128 cites W2567257918 @default.
• W4328137128 cites W2587195208 @default.
• W4328137128 cites W2610901668 @default.
• W4328137128 cites W2610988083 @default.
• W4328137128 cites W2623449852 @default.
• W4328137128 cites W2671981991 @default.
• W4328137128 cites W2746601664 @default.
• W4328137128 cites W2750923352 @default.
• W4328137128 cites W2773754711 @default.
• W4328137128 cites W2810418910 @default.
• W4328137128 cites W2810760527 @default.
• W4328137128 cites W2941957417 @default.
• W4328137128 cites W2954049377 @default.
• W4328137128 cites W2972487336 @default.
• W4328137128 cites W3007757041 @default.
• W4328137128 cites W3011377678 @default.
• W4328137128 cites W3014755300 @default.
• W4328137128 cites W3046711385 @default.
• W4328137128 cites W3111642931 @default.
• W4328137128 cites W3117437033 @default.
• W4328137128 cites W3163617879 @default.
• W4328137128 cites W3193455950 @default.
• W4328137128 cites W3193944814 @default.
• W4328137128 cites W3202980917 @default.
• W4328137128 cites W3210760662 @default.
• W4328137128 cites W4200324043 @default.
• W4328137128 doi "https://doi.org/10.1016/j.jnutbio.2023.109294" @default.
• W4328137128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36948431" @default.
• W4328137128 hasPublicationYear "2023" @default.
• W4328137128 type Work @default.
• W4328137128 citedByCount "0" @default.
• W4328137128 crossrefType "journal-article" @default.
• W4328137128 hasAuthorship W4328137128A5016450118 @default.
• W4328137128 hasAuthorship W4328137128A5049280812 @default.
• W4328137128 hasAuthorship W4328137128A5056555947 @default.
• W4328137128 hasAuthorship W4328137128A5075729887 @default.
• W4328137128 hasConcept C126322002 @default.
• W4328137128 hasConcept C185592680 @default.
• W4328137128 hasConcept C189165786 @default.
• W4328137128 hasConcept C203014093 @default.
• W4328137128 hasConcept C207865475 @default.
• W4328137128 hasConcept C2776232574 @default.
• W4328137128 hasConcept C2776694085 @default.
• W4328137128 hasConcept C2777699602 @default.
• W4328137128 hasConcept C2778004101 @default.
• W4328137128 hasConcept C2778407507 @default.
• W4328137128 hasConcept C2780559512 @default.
• W4328137128 hasConcept C2781244666 @default.
• W4328137128 hasConcept C502942594 @default.
• W4328137128 hasConcept C55493867 @default.
• W4328137128 hasConcept C71924100 @default.
• W4328137128 hasConcept C86803240 @default.
• W4328137128 hasConcept C95444343 @default.
• W4328137128 hasConceptScore W4328137128C126322002 @default.
• W4328137128 hasConceptScore W4328137128C185592680 @default.
• W4328137128 hasConceptScore W4328137128C189165786 @default.
• W4328137128 hasConceptScore W4328137128C203014093 @default.
• W4328137128 hasConceptScore W4328137128C207865475 @default.
• W4328137128 hasConceptScore W4328137128C2776232574 @default.

• next