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• W4328137163 endingPage "112734" @default.
• W4328137163 startingPage "112734" @default.
• W4328137163 abstract "Recent findings imply that great consideration should be given to the potential health risks of food additives on gut microbiota. Glycerol monocaprylate (GMC) is a widely consumed food preservative and emulsifier. Our results indicated that GMC significantly ameliorated visceral fat accumulation and systemic inflammation in high-fat diet (HFD)-fed mice. Furthermore, GMC induced improvements on the composition and function of gut microbiota, resulting in increased beneficial gut bacteria (Bifidobacterium and Lactobacillus) and promoted production of short chain fatty acids. Notably, GMC-induced metabolic amelioration is closely related to the regulation in gut microbiota. Overall, our findings supported that unlike the emulsifiers previously reported to damage intestinal health, GMC performed the potential on attenuating HFD-induced metabolic disorders and gut microbiota dysbiosis, which also refined on the safety evaluation of GMC on gut microbiota. Our findings suggest that when evaluating the safety of food additives with regards to gut microbiota, it is important to take into account the specific characteristics of the additive in question, rather than simply relying on its classification." @default.
• W4328137163 created "2023-03-22" @default.
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• W4328137163 date "2023-05-01" @default.
• W4328137163 modified "2023-10-15" @default.
• W4328137163 title "Food additive glycerol monocaprylate modulated systemic inflammation and gut microbiota without stimulating metabolic dysfunction in high-fat diet fed mice" @default.
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• W4328137163 doi "https://doi.org/10.1016/j.foodres.2023.112734" @default.
• W4328137163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37087285" @default.
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