FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328137361> ?p ?o ?g. }

• W4328137361 abstract "The diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL) and, despite all the progress in this field, central nervous system infiltration (CNSi) still occurs at an incidence of 2-10%. The objective of the present study was to evaluate the Central Nervous System International Prognostic Index (CNS-IPI) score in daily practice regarding the reproducibility in a heterogeneous cohort apart from a clinical trial.Primary DLBCL patients were eligible for this study, between January 2007 and January 2017. All patients were treated with rituximab-based chemotherapy, mostly R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). The CNSi was diagnosed by liquor (positive cytology and/or immunophenotype), computerized tomography, magnetic resonance image and/or fluorodeoxy-glucose-positron emission tomography, requested only in symptomatic patients when the CNSi was clinically suspected. The CNS-IPI was assessed by graphical comparison and calibration.After applying the inclusion/exclusion criteria, 322 patients were available for the analysis. The median follow-up was 60 months and the median age was 58 years. Seven patients experienced CNSi, characterizing an incidence of 2.17% (7/322). Comparing groups of patients with and without CNSi, we observed that the lactate dehydrogenase (LDH), number of extranodal sites, IPI, kidney/adrenal and absence of complete response were statistically different. The CNS-IPI model stratified patients in a three-risk group model as low-, intermediate- and high-risk. In our cohort, using the same stratification, we obtained an equivalent the 2-year rate of CNS relapse of 0.0%, 0.8% and 13.8%, respectively.Our study reinforces the reproducibility of the CNS-IPI, specifically apart from clinical trials, and suggests the CNS-IPI score as a tool to guide therapy." @default.
• W4328137361 created "2023-03-22" @default.
• W4328137361 creator A5006007579 @default.
• W4328137361 creator A5011682957 @default.
• W4328137361 creator A5016675882 @default.
• W4328137361 creator A5023478556 @default.
• W4328137361 creator A5045284944 @default.
• W4328137361 creator A5052442558 @default.
• W4328137361 date "2023-03-01" @default.
• W4328137361 modified "2023-09-25" @default.
• W4328137361 title "Application of the Central Nervous System International Prognostic Index (CNS-IPI) score in daily practice: a retrospective analysis apart from the clinical trial at two centers in Brazil" @default.
• W4328137361 cites W1993442932 @default.
• W4328137361 cites W2018831283 @default.
• W4328137361 cites W2030776533 @default.
• W4328137361 cites W2038023916 @default.
• W4328137361 cites W2075456403 @default.
• W4328137361 cites W2077554728 @default.
• W4328137361 cites W2096047333 @default.
• W4328137361 cites W2106928992 @default.
• W4328137361 cites W2110520204 @default.
• W4328137361 cites W2119147717 @default.
• W4328137361 cites W2127565050 @default.
• W4328137361 cites W2130812537 @default.
• W4328137361 cites W2133201432 @default.
• W4328137361 cites W2142991507 @default.
• W4328137361 cites W2154868392 @default.
• W4328137361 cites W2280269954 @default.
• W4328137361 cites W2310716991 @default.
• W4328137361 cites W2462981464 @default.
• W4328137361 cites W2525561810 @default.
• W4328137361 cites W2531432151 @default.
• W4328137361 cites W2590821302 @default.
• W4328137361 cites W2622585755 @default.
• W4328137361 cites W2768249480 @default.
• W4328137361 cites W2797584152 @default.
• W4328137361 cites W2919015634 @default.
• W4328137361 cites W4200303223 @default.
• W4328137361 cites W4205736005 @default.
• W4328137361 cites W4206925436 @default.
• W4328137361 cites W4282920693 @default.
• W4328137361 doi "https://doi.org/10.1016/j.htct.2023.02.003" @default.
• W4328137361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37085346" @default.
• W4328137361 hasPublicationYear "2023" @default.
• W4328137361 type Work @default.
• W4328137361 citedByCount "0" @default.
• W4328137361 crossrefType "journal-article" @default.
• W4328137361 hasAuthorship W4328137361A5006007579 @default.
• W4328137361 hasAuthorship W4328137361A5011682957 @default.
• W4328137361 hasAuthorship W4328137361A5016675882 @default.
• W4328137361 hasAuthorship W4328137361A5023478556 @default.
• W4328137361 hasAuthorship W4328137361A5045284944 @default.
• W4328137361 hasAuthorship W4328137361A5052442558 @default.
• W4328137361 hasBestOaLocation W43281373611 @default.
• W4328137361 hasConcept C126322002 @default.
• W4328137361 hasConcept C141071460 @default.
• W4328137361 hasConcept C2776694085 @default.
• W4328137361 hasConcept C2776755627 @default.
• W4328137361 hasConcept C2778476033 @default.
• W4328137361 hasConcept C2778720950 @default.
• W4328137361 hasConcept C2779338263 @default.
• W4328137361 hasConcept C2779429289 @default.
• W4328137361 hasConcept C2780653079 @default.
• W4328137361 hasConcept C2781173314 @default.
• W4328137361 hasConcept C71924100 @default.
• W4328137361 hasConcept C72563966 @default.
• W4328137361 hasConceptScore W4328137361C126322002 @default.
• W4328137361 hasConceptScore W4328137361C141071460 @default.
• W4328137361 hasConceptScore W4328137361C2776694085 @default.
• W4328137361 hasConceptScore W4328137361C2776755627 @default.
• W4328137361 hasConceptScore W4328137361C2778476033 @default.
• W4328137361 hasConceptScore W4328137361C2778720950 @default.
• W4328137361 hasConceptScore W4328137361C2779338263 @default.
• W4328137361 hasConceptScore W4328137361C2779429289 @default.
• W4328137361 hasConceptScore W4328137361C2780653079 @default.
• W4328137361 hasConceptScore W4328137361C2781173314 @default.
• W4328137361 hasConceptScore W4328137361C71924100 @default.
• W4328137361 hasConceptScore W4328137361C72563966 @default.
• W4328137361 hasFunder F4320321091 @default.
• W4328137361 hasLocation W43281373611 @default.
• W4328137361 hasLocation W43281373612 @default.
• W4328137361 hasOpenAccess W4328137361 @default.
• W4328137361 hasPrimaryLocation W43281373611 @default.
• W4328137361 hasRelatedWork W1966216463 @default.
• W4328137361 hasRelatedWork W1967766014 @default.
• W4328137361 hasRelatedWork W2119651556 @default.
• W4328137361 hasRelatedWork W2139211474 @default.
• W4328137361 hasRelatedWork W2153978703 @default.
• W4328137361 hasRelatedWork W2345201688 @default.
• W4328137361 hasRelatedWork W3089840555 @default.
• W4328137361 hasRelatedWork W3212185513 @default.
• W4328137361 hasRelatedWork W4284698212 @default.
• W4328137361 hasRelatedWork W4312704659 @default.
• W4328137361 isParatext "false" @default.
• W4328137361 isRetracted "false" @default.
• W4328137361 workType "article" @default.