FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328138219> ?p ?o ?g. }

• W4328138219 endingPage "e069243" @default.
• W4328138219 startingPage "e069243" @default.
• W4328138219 abstract "Introduction Outcomes of traumatic brain injury (TBI) are highly variable, with cognitive and psychiatric problems often present in survivors, including an increased dementia risk in the long term. Military personnel are at an increased occupational risk of TBI, with high rates of complex polytrauma including TBI characterising the UK campaign in Afghanistan. The ArmeD SerVices TrAuma and RehabilitatioN OutComE (ADVANCE)-TBI substudy will describe the patterns, associations and long-term outcomes of TBI in the established ADVANCE cohort. Methods and analysis The ADVANCE cohort comprises 579 military personnel exposed to major battlefield trauma requiring medical evacuation, and 566 matched military personnel without major trauma. TBI exposure has been captured at baseline using a standardised interview and registry data, and will be refined at first follow-up visit with the Ohio State Method TBI interview (a National Institute of Neurological Disorders and Stroke TBI common data element). Participants will undergo blood sampling, MRI and detailed neuropsychological assessment longitudinally as part of their follow-up visits every 3–5 years over a 20-year period. Biomarkers of injury, neuroinflammation and degeneration will be quantified in blood, and polygenic risk scores calculated for neurodegeneration. Age-matched healthy volunteers will be recruited as controls for MRI analyses. We will describe TBI exposure across the cohort, and consider any relationship with advanced biomarkers of injury and clinical outcomes including cognitive performance, neuropsychiatric symptom burden and function. The influence of genotype will be assessed. This research will explore the relationship between military head injury exposure and long-term outcomes, providing insights into underlying disease mechanisms and informing prevention interventions. Ethics and dissemination The ADVANCE-TBI substudy has received a favourable opinion from the Ministry of Defence Research Ethics Committee (ref: 2126/MODREC/22). Findings will be disseminated via publications in peer-reviewed journals and presentations at conferences." @default.
• W4328138219 created "2023-03-22" @default.
• W4328138219 creator A5004178080 @default.
• W4328138219 creator A5023639195 @default.
• W4328138219 creator A5027046422 @default.
• W4328138219 creator A5027152344 @default.
• W4328138219 creator A5042936423 @default.
• W4328138219 creator A5046549789 @default.
• W4328138219 creator A5049119867 @default.
• W4328138219 creator A5050803004 @default.
• W4328138219 creator A5053786717 @default.
• W4328138219 creator A5059071703 @default.
• W4328138219 creator A5064327334 @default.
• W4328138219 creator A5073540479 @default.
• W4328138219 creator A5073721007 @default.
• W4328138219 creator A5075776335 @default.
• W4328138219 creator A5076793010 @default.
• W4328138219 creator A5079766290 @default.
• W4328138219 date "2023-03-01" @default.
• W4328138219 modified "2023-10-14" @default.
• W4328138219 title "ADVANCE-TBI study protocol: traumatic brain injury outcomes in UK military personnel serving in Afghanistan between 2003 and 2014 – a longitudinal cohort study" @default.
• W4328138219 cites W182910583 @default.
• W4328138219 cites W1973798645 @default.
• W4328138219 cites W1990166011 @default.
• W4328138219 cites W2000555003 @default.
• W4328138219 cites W2011595299 @default.
• W4328138219 cites W2035445406 @default.
• W4328138219 cites W2042933433 @default.
• W4328138219 cites W2043705607 @default.
• W4328138219 cites W2057739090 @default.
• W4328138219 cites W2069125464 @default.
• W4328138219 cites W2085246236 @default.
• W4328138219 cites W2085362431 @default.
• W4328138219 cites W2095102390 @default.
• W4328138219 cites W2100240119 @default.
• W4328138219 cites W2116016048 @default.
• W4328138219 cites W2119342009 @default.
• W4328138219 cites W2141464042 @default.
• W4328138219 cites W2150667092 @default.
• W4328138219 cites W2157804149 @default.
• W4328138219 cites W2171263551 @default.
• W4328138219 cites W2174561539 @default.
• W4328138219 cites W2193207784 @default.
• W4328138219 cites W2421918142 @default.
• W4328138219 cites W2571157501 @default.
• W4328138219 cites W2572856951 @default.
• W4328138219 cites W2615261953 @default.
• W4328138219 cites W2618596952 @default.
• W4328138219 cites W2638580840 @default.
• W4328138219 cites W2766872624 @default.
• W4328138219 cites W2767813783 @default.
• W4328138219 cites W2782036709 @default.
• W4328138219 cites W2916749909 @default.
• W4328138219 cites W2921483182 @default.
• W4328138219 cites W2973476620 @default.
• W4328138219 cites W3041099631 @default.
• W4328138219 cites W3092849554 @default.
• W4328138219 cites W3094034242 @default.
• W4328138219 cites W3096469913 @default.
• W4328138219 cites W3100067241 @default.
• W4328138219 cites W3106828261 @default.
• W4328138219 cites W3166254219 @default.
• W4328138219 cites W3185740435 @default.
• W4328138219 cites W3204727263 @default.
• W4328138219 cites W3206653484 @default.
• W4328138219 cites W3215688618 @default.
• W4328138219 cites W4205104973 @default.
• W4328138219 cites W4226435506 @default.
• W4328138219 cites W4245670875 @default.
• W4328138219 cites W4281766055 @default.
• W4328138219 cites W4283029680 @default.
• W4328138219 cites W573909598 @default.
• W4328138219 doi "https://doi.org/10.1136/bmjopen-2022-069243" @default.
• W4328138219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36944467" @default.
• W4328138219 hasPublicationYear "2023" @default.
• W4328138219 type Work @default.
• W4328138219 citedByCount "0" @default.
• W4328138219 crossrefType "journal-article" @default.
• W4328138219 hasAuthorship W4328138219A5004178080 @default.
• W4328138219 hasAuthorship W4328138219A5023639195 @default.
• W4328138219 hasAuthorship W4328138219A5027046422 @default.
• W4328138219 hasAuthorship W4328138219A5027152344 @default.
• W4328138219 hasAuthorship W4328138219A5042936423 @default.
• W4328138219 hasAuthorship W4328138219A5046549789 @default.
• W4328138219 hasAuthorship W4328138219A5049119867 @default.
• W4328138219 hasAuthorship W4328138219A5050803004 @default.
• W4328138219 hasAuthorship W4328138219A5053786717 @default.
• W4328138219 hasAuthorship W4328138219A5059071703 @default.
• W4328138219 hasAuthorship W4328138219A5064327334 @default.
• W4328138219 hasAuthorship W4328138219A5073540479 @default.
• W4328138219 hasAuthorship W4328138219A5073721007 @default.
• W4328138219 hasAuthorship W4328138219A5075776335 @default.
• W4328138219 hasAuthorship W4328138219A5076793010 @default.
• W4328138219 hasAuthorship W4328138219A5079766290 @default.
• W4328138219 hasBestOaLocation W43281382191 @default.
• W4328138219 hasConcept C118552586 @default.
• W4328138219 hasConcept C126322002 @default.
• W4328138219 hasConcept C14216870 @default.

• next