FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328142952> ?p ?o ?g. }

• W4328142952 endingPage "114565" @default.
• W4328142952 startingPage "114565" @default.
• W4328142952 abstract "Global warming increases the incidence of heat stroke (HS) and HS causes the reduction of visceral blood flow during hyperthermia, leading to intestinal barrier disruption, microbial translocation, systemic inflammation and multiple organ failure. Cathelicidin LL-37 exhibits antimicrobial activities, helps innate immunity within the gut to maintain intestinal homeostasis, and augments intestinal wound healing and barrier function. Thus, we evaluated the effects and possible mechanisms of cathelicidin LL-37 on HS. Wistar rats were placed in a heating-chamber of 42 ̊C to induce HS. Changes in rectal temperature, hemodynamic parameters, and survival rate were measured during the experimental period. Blood samples and ilea were collected to analyze the effects of LL-37 on systemic inflammation, multiple organ dysfunction, and intestinal injury. Furthermore, LS174T and HT-29 cells were used to assess the underlying mechanisms. Our data showed cathelicidin LL-37 ameliorated the damage of intestinal cells induced by HS. Intestinal injury, systemic inflammation, and nitrosative stress (high nitric oxide level) caused by continuous hyperthermia were attenuated in HS rats treated with cathelicidin LL-37, and hence, improved multiple organ dysfunction, coagulopathy, and survival rate. These beneficial effects of cathelicidin LL-37 were attributed to the protection of intestinal goblet cells (by increasing transepithelial resistance, mucin-2 and Nrf2 expression) and the improvement of intestinal barrier function (less cyclooxygenase-2 expression and FITC-dextran translocation). Interestingly, high cathelicidin expression in the ileal samples of inflammatory bowel disease patients was associated with better clinical outcome. These results suggest that cathelicidin LL-37 could prevent heat stress-induced intestinal damage and heat-related illnesses." @default.
• W4328142952 created "2023-03-22" @default.
• W4328142952 creator A5012209697 @default.
• W4328142952 creator A5018408927 @default.
• W4328142952 creator A5023707056 @default.
• W4328142952 creator A5032276026 @default.
• W4328142952 creator A5034891355 @default.
• W4328142952 creator A5064169659 @default.
• W4328142952 creator A5068387675 @default.
• W4328142952 creator A5081268054 @default.
• W4328142952 creator A5089356698 @default.
• W4328142952 date "2023-05-01" @default.
• W4328142952 modified "2023-10-14" @default.
• W4328142952 title "Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke" @default.
• W4328142952 cites W1506297407 @default.
• W4328142952 cites W1522866020 @default.
• W4328142952 cites W1858048769 @default.
• W4328142952 cites W1943160106 @default.
• W4328142952 cites W1971042231 @default.
• W4328142952 cites W1973067432 @default.
• W4328142952 cites W1976282139 @default.
• W4328142952 cites W1977673422 @default.
• W4328142952 cites W1984394808 @default.
• W4328142952 cites W1991412326 @default.
• W4328142952 cites W1994730928 @default.
• W4328142952 cites W1997868832 @default.
• W4328142952 cites W2010457001 @default.
• W4328142952 cites W2011175910 @default.
• W4328142952 cites W2011337131 @default.
• W4328142952 cites W2013133956 @default.
• W4328142952 cites W2021413161 @default.
• W4328142952 cites W2024255214 @default.
• W4328142952 cites W2027399301 @default.
• W4328142952 cites W2048527381 @default.
• W4328142952 cites W2052252017 @default.
• W4328142952 cites W2054968150 @default.
• W4328142952 cites W2068529704 @default.
• W4328142952 cites W2069388628 @default.
• W4328142952 cites W2072432297 @default.
• W4328142952 cites W2085074249 @default.
• W4328142952 cites W2086368575 @default.
• W4328142952 cites W2101339759 @default.
• W4328142952 cites W2106315342 @default.
• W4328142952 cites W2120950548 @default.
• W4328142952 cites W2120978504 @default.
• W4328142952 cites W2129785704 @default.
• W4328142952 cites W2141630917 @default.
• W4328142952 cites W2142461098 @default.
• W4328142952 cites W2147574532 @default.
• W4328142952 cites W2159707944 @default.
• W4328142952 cites W2169759699 @default.
• W4328142952 cites W2171528197 @default.
• W4328142952 cites W2212327748 @default.
• W4328142952 cites W226945004 @default.
• W4328142952 cites W2316398716 @default.
• W4328142952 cites W2405209257 @default.
• W4328142952 cites W2416512025 @default.
• W4328142952 cites W2577816239 @default.
• W4328142952 cites W2754731081 @default.
• W4328142952 cites W2765448255 @default.
• W4328142952 cites W2783069526 @default.
• W4328142952 cites W2803656008 @default.
• W4328142952 cites W2910369498 @default.
• W4328142952 cites W2944345783 @default.
• W4328142952 cites W2969634387 @default.
• W4328142952 cites W3012105084 @default.
• W4328142952 cites W3012559026 @default.
• W4328142952 cites W3083793804 @default.
• W4328142952 cites W3092484485 @default.
• W4328142952 cites W3101971210 @default.
• W4328142952 cites W3106811464 @default.
• W4328142952 cites W3164122911 @default.
• W4328142952 cites W3175089144 @default.
• W4328142952 cites W3198804687 @default.
• W4328142952 cites W3202084426 @default.
• W4328142952 cites W4206384008 @default.
• W4328142952 cites W4210528561 @default.
• W4328142952 doi "https://doi.org/10.1016/j.biopha.2023.114565" @default.
• W4328142952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36958193" @default.
• W4328142952 hasPublicationYear "2023" @default.
• W4328142952 type Work @default.
• W4328142952 citedByCount "0" @default.
• W4328142952 crossrefType "journal-article" @default.
• W4328142952 hasAuthorship W4328142952A5012209697 @default.
• W4328142952 hasAuthorship W4328142952A5018408927 @default.
• W4328142952 hasAuthorship W4328142952A5023707056 @default.
• W4328142952 hasAuthorship W4328142952A5032276026 @default.
• W4328142952 hasAuthorship W4328142952A5034891355 @default.
• W4328142952 hasAuthorship W4328142952A5064169659 @default.
• W4328142952 hasAuthorship W4328142952A5068387675 @default.
• W4328142952 hasAuthorship W4328142952A5081268054 @default.
• W4328142952 hasAuthorship W4328142952A5089356698 @default.
• W4328142952 hasBestOaLocation W43281429521 @default.
• W4328142952 hasConcept C118303440 @default.
• W4328142952 hasConcept C126322002 @default.
• W4328142952 hasConcept C136449434 @default.
• W4328142952 hasConcept C170493617 @default.
• W4328142952 hasConcept C203014093 @default.

• next