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- W433386811 abstract "The introduction of drugs that could induce hypotension with different pharmacological actions would be advantageous because side effects unique to a specific drug could be minimized by selecting appropriate therapy. Specific dopamine-l, (DAI) and dopamine-2 (DA2) receptor agonists are now under clinical investigation. Fenoldopam me~ylate is a specific DAI receptor agonist that lowers blood pressure by vasodilatation. The hypothesis that fenoldopam could be used to induce hypotension and preserve blood flow to the kidney was tested. Systemic aortic blood pressure and renal blood flow were measured continuously with a carotid arterial catheter and an electromagnetic flow probe respectively, in order to compare the cardiovascular and renal vascular effects of fenoldopam and sodium nitroprusside in ten dogs under halothane general anaesthesia. Mean arterial pressure was decreased 30 +- 8 per cent from control with infusion of fenoldoparn (3.4 2.0 I~g kg -t ' rain -I ) and34 4" @default.
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- W433386811 date "1990-01-01" @default.
- W433386811 modified "2023-09-27" @default.
- W433386811 title "Laboratory Investigation Preservation of renal blood flow during hypotension induced with fenoldopam in dogs" @default.
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