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- W43345693 abstract "In order to test the thousands of man-made chemicals in the environment for carcinogenic and genetic hazards, a multitude of short-term screening tests has been developed to complement long-term mammalian bioassays and epidemiological studies. These tests cover a broad spectrum of organisms, and include the use of naked and viral nucleic acids, bacteria, fungi, higher plants, insects in vitro mammalian cell cultures (cell transformation, cell-mediated mutagenesis, DNA repair, and chromosome aberration tests) and live mammals. Assay end points include effects on nucleic acids, DNA repair synthesis, point or gene mutation, structural and numerical chromosome aberrations, cytological alterations, and in vitro cell transformation. The present review describes and compares these assays. In addition, it discusses their historical development, the problems and limitations associated with their use, and their implementation in comprehensive testing programs. It is intended to provide overview and specific information to the laboratory that is in the process of establishing genetic toxicological systems. (The literature is reviewed to January 1978.)" @default.
- W43345693 created "2016-06-24" @default.
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- W43345693 date "1979-07-01" @default.
- W43345693 modified "2023-09-27" @default.
- W43345693 title "Review of short-term screening tests for mutagens, toxigens, and carcinogens" @default.
- W43345693 doi "https://doi.org/10.2172/6137750" @default.
- W43345693 hasPublicationYear "1979" @default.
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