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- W43350306 abstract "1727 Objectives To clarify the difference between system A and L amino acid transport imaging in clinical PET, we analyze the pharmacokinetics and the parametric images of [N-methyl-11C]α-methylaminoisobutyric acid ([11C]-MeAIB) as a marker of system A transport and of [S-methyl-11C]-L-methionine ([11C]-MET) as a marker of system L. Methods Six normal healthy subjects received intravenous injection of both [11C]-MeAIB and [11C]-MET, respectively in other day, and dynamic and static PET images were obtained. Plasma and pancreas time-activity curve were analyzed graphically using pharmacokinetic modeling with 1 tissue-compartment modeling, followed by the voxel-based parametric image analysis. Results In both PET images, peak plasma accumulation were observed in 2 min after injection and decreased tri-exponentially, while pancreas showed constant increased uptake because of system A and L amino acid transports. In pharmacokinetic modeling from the time-activity curves, parameters of K1, K2 and Vt were 0.21±0.12, 0.10±0.06, 1.99±0.19 for [11C]-MeAIB and 0.44±0.05, 0.04±0.03, 10.46±4.32 for [11C]-MET, respectively (P Conclusions System A and L amino acid transport image analysis were obtained with [11C]-MeAIB and [11C]-MET PET in human pancreas. These PET imaging would contribute to assess the activity of amino acid transports in various diseases such as neoplasm." @default.
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- W43350306 date "2009-05-01" @default.
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- W43350306 title "Comparison of system A and system L amino acid transports in human pancreas with C-11 MeAIB and C-11 MET PET study" @default.
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