Matches in SemOpenAlex for { <https://semopenalex.org/work/W433565530> ?p ?o ?g. }
- W433565530 endingPage "57" @default.
- W433565530 startingPage "47" @default.
- W433565530 abstract "The compound LASSBio-788 (N-Allyl (2-thienylidene) 3,4-methylenedioxybenzoylhydrazine) is a thienylacylhydrazone derivative shown to have antiplatelet, vasodilatory, and anti-inflammatory properties in vitro. We hypothesize that LASSBio-788 may exert beneficial effects on atherosclerosis. Male wistar rats were divided into 4 groups: Control group received standard rat chow, hypercholesterolemic group (HC) and HC+788 (compound LASSBio-788 group) received hypercholesterolemic diet for 45 days. HC+788 group received compound LASSBio-788 (100 μmol/kg) once daily in the last 15 days. LASSBio-788 reduced the levels of total cholesterol (109.1 ± 4.3 vs. 361.0 ± 12.8 mg/dl), triglycerides (66.1 ± 1.1 vs. 186.9 ± 17.7 mg/dl), LDLc (63.2 ± 6.1 vs. 330.9 ± 9.7 mg/dl), VLDLc (9.8 ± 1.1 vs. 45.0 ± 4.6 mg/dl) and malondialdehyde (4.8 ± 0.3 vs. 9.4 ± 0.5 nmol/ml) compared to the HC group. LASSBio-788 presented antiplatelet properties and decreased inflammatory markers levels. LASSBio-788 promoted a decrease in contractile response to phenylephrine and an improvement in endothelium-dependent vasorelaxant response by increasing two-fold the expression of nitric oxide synthase (eNOS). Our results suggest that the compound LASSBio-788 represents a new multi-targeted drug candidate for the treatment of atherosclerosis." @default.
- W433565530 created "2016-06-24" @default.
- W433565530 creator A5012806147 @default.
- W433565530 creator A5030249797 @default.
- W433565530 creator A5031436488 @default.
- W433565530 creator A5036368916 @default.
- W433565530 creator A5045459148 @default.
- W433565530 creator A5062842039 @default.
- W433565530 creator A5072208746 @default.
- W433565530 creator A5076822552 @default.
- W433565530 date "2013-01-01" @default.
- W433565530 modified "2023-09-25" @default.
- W433565530 title "Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet" @default.
- W433565530 cites W1533864997 @default.
- W433565530 cites W1965470038 @default.
- W433565530 cites W1969592317 @default.
- W433565530 cites W1970541648 @default.
- W433565530 cites W1973042046 @default.
- W433565530 cites W1980919064 @default.
- W433565530 cites W1983310681 @default.
- W433565530 cites W1991469067 @default.
- W433565530 cites W1992912936 @default.
- W433565530 cites W1993476803 @default.
- W433565530 cites W1994506978 @default.
- W433565530 cites W1998823460 @default.
- W433565530 cites W2007599029 @default.
- W433565530 cites W2025477871 @default.
- W433565530 cites W2025817658 @default.
- W433565530 cites W2049913183 @default.
- W433565530 cites W2051048068 @default.
- W433565530 cites W2051618758 @default.
- W433565530 cites W2060773732 @default.
- W433565530 cites W2061658525 @default.
- W433565530 cites W2062219824 @default.
- W433565530 cites W2065623224 @default.
- W433565530 cites W2071461268 @default.
- W433565530 cites W2078328099 @default.
- W433565530 cites W2088207396 @default.
- W433565530 cites W2090622665 @default.
- W433565530 cites W2100837269 @default.
- W433565530 cites W2122043662 @default.
- W433565530 cites W2129826639 @default.
- W433565530 cites W2134712306 @default.
- W433565530 cites W2156030365 @default.
- W433565530 cites W2160256386 @default.
- W433565530 cites W2324841714 @default.
- W433565530 cites W3022864527 @default.
- W433565530 cites W4232746434 @default.
- W433565530 doi "https://doi.org/10.1254/jphs.13016fp" @default.
- W433565530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24018841" @default.
- W433565530 hasPublicationYear "2013" @default.
- W433565530 type Work @default.
- W433565530 sameAs 433565530 @default.
- W433565530 citedByCount "13" @default.
- W433565530 countsByYear W4335655302015 @default.
- W433565530 countsByYear W4335655302016 @default.
- W433565530 countsByYear W4335655302017 @default.
- W433565530 countsByYear W4335655302019 @default.
- W433565530 countsByYear W4335655302020 @default.
- W433565530 countsByYear W4335655302022 @default.
- W433565530 crossrefType "journal-article" @default.
- W433565530 hasAuthorship W433565530A5012806147 @default.
- W433565530 hasAuthorship W433565530A5030249797 @default.
- W433565530 hasAuthorship W433565530A5031436488 @default.
- W433565530 hasAuthorship W433565530A5036368916 @default.
- W433565530 hasAuthorship W433565530A5045459148 @default.
- W433565530 hasAuthorship W433565530A5062842039 @default.
- W433565530 hasAuthorship W433565530A5072208746 @default.
- W433565530 hasAuthorship W433565530A5076822552 @default.
- W433565530 hasBestOaLocation W4335655301 @default.
- W433565530 hasConcept C120770815 @default.
- W433565530 hasConcept C126322002 @default.
- W433565530 hasConcept C134018914 @default.
- W433565530 hasConcept C185592680 @default.
- W433565530 hasConcept C2776151105 @default.
- W433565530 hasConcept C2777622882 @default.
- W433565530 hasConcept C2778326061 @default.
- W433565530 hasConcept C2778401633 @default.
- W433565530 hasConcept C519581460 @default.
- W433565530 hasConcept C55493867 @default.
- W433565530 hasConcept C71240020 @default.
- W433565530 hasConcept C71924100 @default.
- W433565530 hasConceptScore W433565530C120770815 @default.
- W433565530 hasConceptScore W433565530C126322002 @default.
- W433565530 hasConceptScore W433565530C134018914 @default.
- W433565530 hasConceptScore W433565530C185592680 @default.
- W433565530 hasConceptScore W433565530C2776151105 @default.
- W433565530 hasConceptScore W433565530C2777622882 @default.
- W433565530 hasConceptScore W433565530C2778326061 @default.
- W433565530 hasConceptScore W433565530C2778401633 @default.
- W433565530 hasConceptScore W433565530C519581460 @default.
- W433565530 hasConceptScore W433565530C55493867 @default.
- W433565530 hasConceptScore W433565530C71240020 @default.
- W433565530 hasConceptScore W433565530C71924100 @default.
- W433565530 hasIssue "1" @default.
- W433565530 hasLocation W4335655301 @default.
- W433565530 hasLocation W4335655302 @default.
- W433565530 hasOpenAccess W433565530 @default.