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• W43477025 abstract "Auto/paracrine cell-to-cell communications via diffusive messengers can be coupled to a positive feedback loop in which cell stimulation by a messenger results in the production of new messengers. This yields a potential mechanism for relay transmission of the emitted message. This paper investigates the influence of noise on this mutual coupling of the cells with their environment, using numerical simulations of a stochastic minimal model. The results demonstrate that the deterministic (mean-field) approximation of this stochastic process fails short of predicting its behaviour because of the presence of strong noise-induced fluctuations. Instead, the behaviour of the model can be explained by the occurrence of a nonequilibrium phase transition, which is found to be in the universality class of directed percolation. This provides a theoretical framework to understand signal transmission in these stochastic systems." @default.
• W43477025 created "2016-06-24" @default.
• W43477025 creator A5021999741 @default.
• W43477025 date "2008-08-13" @default.
• W43477025 modified "2023-09-27" @default.
• W43477025 title "Nonequilibrium Phase Transition in Scattered Cell Communities Coupled by Auto/Paracrine-Like Signalling" @default.
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• W43477025 doi "https://doi.org/10.1007/978-1-4020-8651-9_2" @default.
• W43477025 hasPublicationYear "2008" @default.
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