Matches in SemOpenAlex for { <https://semopenalex.org/work/W435196252> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W435196252 abstract "Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases affecting 0.05-2% of the population worldwide. Genetic studies detected linkage with SLE in the 2q37 region, and intensive family-based and case-control association studies in several populations identified that allele A of the SNP PD-1.3 located in the immunoreceptor PDCD1 (PD-1) gene, increases risk of the disease by 2.6-fold in Caucasians (p<0.00001) and by 3.5-fold in Mexicans (p=0.0009). The same allele was found to be a risk factor for lupus nephritis, a severe clinical manifestation of SLE. In Swedish and European-American females with SLE, patients with the allele A had nephritis 1.8 times (p=0.01) more often than patients with allele G .Moreover, the allele A was also found 1.8 times (p=0.005) more often in RA patients, negative for the known risk-factors, rheumatoid factor and the shared epitope, than in other groups of patients and controls. Functional studies demonstrated that the mechanism behind the SNP PD-1.3 is related to the disruption of the binding site for RUNX transcription factors in the regulatory region. Expression of the PD-1 and RUNX genes was altered in the activated T cells of SLE patients compared to controls.The Tumor Necrosis Factor Receptor 2 (TNFR 2) gene was studied as a second candidate gene for both SLE and RA. The results of our studies in SLE and RA patients and controls from Sweden and Mexico do not support the association of the polymorphism TNFR 2 M196R with these diseases. Other polymorphisms in this gene and other genes in this region should therefore be studied." @default.
- W435196252 created "2016-06-24" @default.
- W435196252 creator A5003564491 @default.
- W435196252 creator A5016488933 @default.
- W435196252 creator A5016564929 @default.
- W435196252 creator A5037276492 @default.
- W435196252 creator A5038377475 @default.
- W435196252 creator A5039672392 @default.
- W435196252 creator A5041041799 @default.
- W435196252 creator A5044688689 @default.
- W435196252 creator A5053954343 @default.
- W435196252 date "2004-01-01" @default.
- W435196252 modified "2023-10-18" @default.
- W435196252 title "Analysis of the TNFR 2 polymorphism M196R in Swedish and Mexican patients with systemic lupus erythematosus and rheumatoid arthritis" @default.
- W435196252 hasPublicationYear "2004" @default.
- W435196252 type Work @default.
- W435196252 sameAs 435196252 @default.
- W435196252 citedByCount "0" @default.
- W435196252 crossrefType "journal-article" @default.
- W435196252 hasAuthorship W435196252A5003564491 @default.
- W435196252 hasAuthorship W435196252A5016488933 @default.
- W435196252 hasAuthorship W435196252A5016564929 @default.
- W435196252 hasAuthorship W435196252A5037276492 @default.
- W435196252 hasAuthorship W435196252A5038377475 @default.
- W435196252 hasAuthorship W435196252A5039672392 @default.
- W435196252 hasAuthorship W435196252A5041041799 @default.
- W435196252 hasAuthorship W435196252A5044688689 @default.
- W435196252 hasAuthorship W435196252A5053954343 @default.
- W435196252 hasConcept C104317684 @default.
- W435196252 hasConcept C126322002 @default.
- W435196252 hasConcept C135763542 @default.
- W435196252 hasConcept C139275648 @default.
- W435196252 hasConcept C153209595 @default.
- W435196252 hasConcept C159654299 @default.
- W435196252 hasConcept C180754005 @default.
- W435196252 hasConcept C203014093 @default.
- W435196252 hasConcept C2776232647 @default.
- W435196252 hasConcept C2776670291 @default.
- W435196252 hasConcept C2777575956 @default.
- W435196252 hasConcept C2779075594 @default.
- W435196252 hasConcept C2779134260 @default.
- W435196252 hasConcept C2779912601 @default.
- W435196252 hasConcept C2908647359 @default.
- W435196252 hasConcept C37463918 @default.
- W435196252 hasConcept C54355233 @default.
- W435196252 hasConcept C71924100 @default.
- W435196252 hasConcept C86803240 @default.
- W435196252 hasConcept C99454951 @default.
- W435196252 hasConceptScore W435196252C104317684 @default.
- W435196252 hasConceptScore W435196252C126322002 @default.
- W435196252 hasConceptScore W435196252C135763542 @default.
- W435196252 hasConceptScore W435196252C139275648 @default.
- W435196252 hasConceptScore W435196252C153209595 @default.
- W435196252 hasConceptScore W435196252C159654299 @default.
- W435196252 hasConceptScore W435196252C180754005 @default.
- W435196252 hasConceptScore W435196252C203014093 @default.
- W435196252 hasConceptScore W435196252C2776232647 @default.
- W435196252 hasConceptScore W435196252C2776670291 @default.
- W435196252 hasConceptScore W435196252C2777575956 @default.
- W435196252 hasConceptScore W435196252C2779075594 @default.
- W435196252 hasConceptScore W435196252C2779134260 @default.
- W435196252 hasConceptScore W435196252C2779912601 @default.
- W435196252 hasConceptScore W435196252C2908647359 @default.
- W435196252 hasConceptScore W435196252C37463918 @default.
- W435196252 hasConceptScore W435196252C54355233 @default.
- W435196252 hasConceptScore W435196252C71924100 @default.
- W435196252 hasConceptScore W435196252C86803240 @default.
- W435196252 hasConceptScore W435196252C99454951 @default.
- W435196252 hasLocation W4351962521 @default.
- W435196252 hasOpenAccess W435196252 @default.
- W435196252 hasPrimaryLocation W4351962521 @default.
- W435196252 hasRelatedWork W1867005192 @default.
- W435196252 hasRelatedWork W1980589713 @default.
- W435196252 hasRelatedWork W2005140179 @default.
- W435196252 hasRelatedWork W2008472325 @default.
- W435196252 hasRelatedWork W2069553468 @default.
- W435196252 hasRelatedWork W2081937189 @default.
- W435196252 hasRelatedWork W2090343544 @default.
- W435196252 hasRelatedWork W2104920982 @default.
- W435196252 hasRelatedWork W2119176746 @default.
- W435196252 hasRelatedWork W2134066172 @default.
- W435196252 hasRelatedWork W2362328250 @default.
- W435196252 hasRelatedWork W2799813994 @default.
- W435196252 hasRelatedWork W2899757224 @default.
- W435196252 hasRelatedWork W2925152363 @default.
- W435196252 hasRelatedWork W3013015215 @default.
- W435196252 hasRelatedWork W3081653989 @default.
- W435196252 hasRelatedWork W3083292067 @default.
- W435196252 hasRelatedWork W3210754892 @default.
- W435196252 hasRelatedWork W580018339 @default.
- W435196252 hasRelatedWork W2182620769 @default.
- W435196252 isParatext "false" @default.
- W435196252 isRetracted "false" @default.
- W435196252 magId "435196252" @default.
- W435196252 workType "article" @default.