FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353015208> ?p ?o ?g. }

• W4353015208 endingPage "1427" @default.
• W4353015208 startingPage "1419" @default.
• W4353015208 abstract "TLR5, which is activated by flagellin, plays an important role in initiating immune response to a broad spectrum of motile bacterial pathogens. TLRs induce intracellular signaling via dimerization of their TIR domains followed by adapter recruitment through multiple interactions of receptor and adapter TIRs. Here, a library of cell-permeable decoy peptides derived from the TLR5 TIR was screened for TLR5 signaling inhibition in the HEK-Blue-mTLR5 reporter cell line. The peptide demonstrating the strongest inhibition, 5R667, corresponded to the second helix of the region between the third and fourth β-strands (helix C″). In addition to the TLR5-induced cytokine expression, 5R667 inhibited cytokine expression elicited by TLR4, TLR2, and TLR9. 5R667 also suppressed the systemic cytokine induction elicited by LPS administration in mice. 5R667 binding specificity was studied by time-resolved fluorescence spectroscopy in a cell-based assay. 5R667 demonstrated a multispecific binding pattern with respect to TIR domains: It bound TIRs of TLR adapters of the MyD88-dependent pathway, Toll/interleukin-1 receptor domain-containing adapter protein/MyD88 adapter-like (TIRAP) and MyD88, and also the TIR of TLR5. TR667, the peptide derived from the TIRAP region, which is structurally homologous to 5R667, demonstrated binding and inhibitory properties similar to that of 5R667. The surface-exposed residues within TIR regions represented by 5R667 and TR667 form motifs, which are nearly 90% conserved in vertebrate evolution and are distinctive of TLR5 and TIRAP TIR domains. Thus, we have identified an evolutionary conserved adapter recruitment motif within TLR5 TIR, the function of which can be inhibited by selective cell-permeable decoy peptides, which can serve as pan-specific TLR inhibitors." @default.
• W4353015208 created "2023-03-23" @default.
• W4353015208 creator A5016757949 @default.
• W4353015208 creator A5019350885 @default.
• W4353015208 creator A5063274000 @default.
• W4353015208 creator A5071156187 @default.
• W4353015208 creator A5071967253 @default.
• W4353015208 creator A5074798370 @default.
• W4353015208 creator A5089218410 @default.
• W4353015208 date "2023-03-22" @default.
• W4353015208 modified "2023-09-25" @default.
• W4353015208 title "TLR5-Derived, TIR-Interacting Decoy Peptides to Inhibit TLR Signaling" @default.
• W4353015208 cites W1519633296 @default.
• W4353015208 cites W1561771836 @default.
• W4353015208 cites W1572658514 @default.
• W4353015208 cites W1584683177 @default.
• W4353015208 cites W1920324450 @default.
• W4353015208 cites W1928414651 @default.
• W4353015208 cites W1975007025 @default.
• W4353015208 cites W1975840650 @default.
• W4353015208 cites W1987463569 @default.
• W4353015208 cites W1994942139 @default.
• W4353015208 cites W2003726865 @default.
• W4353015208 cites W2015642465 @default.
• W4353015208 cites W2028806189 @default.
• W4353015208 cites W2036051510 @default.
• W4353015208 cites W2038554653 @default.
• W4353015208 cites W2047544230 @default.
• W4353015208 cites W2052003687 @default.
• W4353015208 cites W2067359484 @default.
• W4353015208 cites W2069502810 @default.
• W4353015208 cites W2076680752 @default.
• W4353015208 cites W2077189992 @default.
• W4353015208 cites W2096704339 @default.
• W4353015208 cites W2104017463 @default.
• W4353015208 cites W2106510584 @default.
• W4353015208 cites W2119693712 @default.
• W4353015208 cites W2130501069 @default.
• W4353015208 cites W2133449490 @default.
• W4353015208 cites W2147903280 @default.
• W4353015208 cites W2156445477 @default.
• W4353015208 cites W2742071184 @default.
• W4353015208 cites W2809598090 @default.
• W4353015208 cites W2948946994 @default.
• W4353015208 cites W2981671801 @default.
• W4353015208 cites W3001517470 @default.
• W4353015208 cites W3003569240 @default.
• W4353015208 cites W3034487345 @default.
• W4353015208 cites W3162649153 @default.
• W4353015208 cites W3186179742 @default.
• W4353015208 cites W3001531819 @default.
• W4353015208 doi "https://doi.org/10.4049/jimmunol.2200394" @default.
• W4353015208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36946775" @default.
• W4353015208 hasPublicationYear "2023" @default.
• W4353015208 type Work @default.
• W4353015208 citedByCount "0" @default.
• W4353015208 crossrefType "journal-article" @default.
• W4353015208 hasAuthorship W4353015208A5016757949 @default.
• W4353015208 hasAuthorship W4353015208A5019350885 @default.
• W4353015208 hasAuthorship W4353015208A5063274000 @default.
• W4353015208 hasAuthorship W4353015208A5071156187 @default.
• W4353015208 hasAuthorship W4353015208A5071967253 @default.
• W4353015208 hasAuthorship W4353015208A5074798370 @default.
• W4353015208 hasAuthorship W4353015208A5089218410 @default.
• W4353015208 hasConcept C119599485 @default.
• W4353015208 hasConcept C127413603 @default.
• W4353015208 hasConcept C136449434 @default.
• W4353015208 hasConcept C153911025 @default.
• W4353015208 hasConcept C170493617 @default.
• W4353015208 hasConcept C174510640 @default.
• W4353015208 hasConcept C177284502 @default.
• W4353015208 hasConcept C183786373 @default.
• W4353015208 hasConcept C185592680 @default.
• W4353015208 hasConcept C2776070231 @default.
• W4353015208 hasConcept C2776709828 @default.
• W4353015208 hasConcept C2777338127 @default.
• W4353015208 hasConcept C2778690821 @default.
• W4353015208 hasConcept C2781236682 @default.
• W4353015208 hasConcept C38117629 @default.
• W4353015208 hasConcept C54355233 @default.
• W4353015208 hasConcept C55493867 @default.
• W4353015208 hasConcept C62478195 @default.
• W4353015208 hasConcept C86803240 @default.
• W4353015208 hasConcept C95444343 @default.
• W4353015208 hasConceptScore W4353015208C119599485 @default.
• W4353015208 hasConceptScore W4353015208C127413603 @default.
• W4353015208 hasConceptScore W4353015208C136449434 @default.
• W4353015208 hasConceptScore W4353015208C153911025 @default.
• W4353015208 hasConceptScore W4353015208C170493617 @default.
• W4353015208 hasConceptScore W4353015208C174510640 @default.
• W4353015208 hasConceptScore W4353015208C177284502 @default.
• W4353015208 hasConceptScore W4353015208C183786373 @default.
• W4353015208 hasConceptScore W4353015208C185592680 @default.
• W4353015208 hasConceptScore W4353015208C2776070231 @default.
• W4353015208 hasConceptScore W4353015208C2776709828 @default.
• W4353015208 hasConceptScore W4353015208C2777338127 @default.
• W4353015208 hasConceptScore W4353015208C2778690821 @default.
• W4353015208 hasConceptScore W4353015208C2781236682 @default.

• next