FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353015521> ?p ?o ?g. }

• W4353015521 endingPage "272" @default.
• W4353015521 startingPage "261" @default.
• W4353015521 abstract "Prognostic tools are an essential component of the clinical management of patients with renal cell carcinoma (RCC). Although tumour stage and grade can provide important information, they fail to consider patient- and tumour-specific biology. In this study, we set out to find a novel molecular marker of RCC by using hepatocyte nuclear factor 4A (HNF4A), a transcription factor implicated in RCC progression and malignancy, as a blueprint. Through transcriptomic analyses, we show that the nuclear factor I A (NFIA)-driven transcription network is active in primary RCC and that higher levels of NFIA confer a survival benefit. We validate our findings using immunohistochemical staining and analysis of a 363-patient tissue microarray (TMA), showing for the first time that NFIA can independently predict poor cancer-specific survival in clear cell RCC (ccRCC) patients (hazard ratio = 0.46, 95% CI = 0.24-0.85, p value = 0.014). Furthermore, we confirm the association of HNF4A with higher grades and stages in ccRCC in our TMA cohort. We present novel data that show HNF4A protein expression does not confer favourable prognosis in papillary RCC, confirming our survival analysis with publicly available HNF4A RNA expression data. Further work is required to elucidate the functional role of NFIA in RCC as well as the testing of these markers on patient material from diverse multi-centre cohorts, to establish their value for the prognostication of RCC." @default.
• W4353015521 created "2023-03-23" @default.
• W4353015521 creator A5041859803 @default.
• W4353015521 creator A5067215547 @default.
• W4353015521 creator A5072621284 @default.
• W4353015521 creator A5082828068 @default.
• W4353015521 creator A5088250997 @default.
• W4353015521 creator A5090251760 @default.
• W4353015521 date "2023-03-22" @default.
• W4353015521 modified "2023-09-26" @default.
• W4353015521 title "Identification and validation of <scp>NFIA</scp> as a novel prognostic marker in renal cell carcinoma" @default.
• W4353015521 cites W1480830299 @default.
• W4353015521 cites W1988015039 @default.
• W4353015521 cites W2007943561 @default.
• W4353015521 cites W2013609600 @default.
• W4353015521 cites W2034240230 @default.
• W4353015521 cites W2039545078 @default.
• W4353015521 cites W2076376599 @default.
• W4353015521 cites W2082331198 @default.
• W4353015521 cites W2085557285 @default.
• W4353015521 cites W2094518946 @default.
• W4353015521 cites W2111410841 @default.
• W4353015521 cites W2111867681 @default.
• W4353015521 cites W2112775523 @default.
• W4353015521 cites W2125012054 @default.
• W4353015521 cites W2138093501 @default.
• W4353015521 cites W2141627956 @default.
• W4353015521 cites W2152057203 @default.
• W4353015521 cites W2159837185 @default.
• W4353015521 cites W2161609794 @default.
• W4353015521 cites W2230320310 @default.
• W4353015521 cites W2288944226 @default.
• W4353015521 cites W2293077587 @default.
• W4353015521 cites W2342727411 @default.
• W4353015521 cites W2398400957 @default.
• W4353015521 cites W2616922646 @default.
• W4353015521 cites W2620006923 @default.
• W4353015521 cites W2726542547 @default.
• W4353015521 cites W2742449822 @default.
• W4353015521 cites W2759847459 @default.
• W4353015521 cites W2792827265 @default.
• W4353015521 cites W2805432649 @default.
• W4353015521 cites W2884974323 @default.
• W4353015521 cites W2905298242 @default.
• W4353015521 cites W2952481429 @default.
• W4353015521 cites W2955554143 @default.
• W4353015521 cites W2984472267 @default.
• W4353015521 cites W2997954936 @default.
• W4353015521 cites W3012502371 @default.
• W4353015521 cites W3047797665 @default.
• W4353015521 cites W3112743333 @default.
• W4353015521 cites W3116716364 @default.
• W4353015521 cites W3160973971 @default.
• W4353015521 cites W3164692211 @default.
• W4353015521 cites W3168048358 @default.
• W4353015521 cites W4282932154 @default.
• W4353015521 doi "https://doi.org/10.1002/cjp2.316" @default.
• W4353015521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36947439" @default.
• W4353015521 hasPublicationYear "2023" @default.
• W4353015521 type Work @default.
• W4353015521 citedByCount "0" @default.
• W4353015521 crossrefType "journal-article" @default.
• W4353015521 hasAuthorship W4353015521A5041859803 @default.
• W4353015521 hasAuthorship W4353015521A5067215547 @default.
• W4353015521 hasAuthorship W4353015521A5072621284 @default.
• W4353015521 hasAuthorship W4353015521A5082828068 @default.
• W4353015521 hasAuthorship W4353015521A5088250997 @default.
• W4353015521 hasAuthorship W4353015521A5090251760 @default.
• W4353015521 hasBestOaLocation W43530155211 @default.
• W4353015521 hasConcept C10515644 @default.
• W4353015521 hasConcept C126322002 @default.
• W4353015521 hasConcept C142724271 @default.
• W4353015521 hasConcept C143998085 @default.
• W4353015521 hasConcept C193270364 @default.
• W4353015521 hasConcept C204232928 @default.
• W4353015521 hasConcept C2777472916 @default.
• W4353015521 hasConcept C2778560582 @default.
• W4353015521 hasConcept C2781278892 @default.
• W4353015521 hasConcept C502942594 @default.
• W4353015521 hasConcept C50382708 @default.
• W4353015521 hasConcept C71924100 @default.
• W4353015521 hasConcept C86803240 @default.
• W4353015521 hasConceptScore W4353015521C10515644 @default.
• W4353015521 hasConceptScore W4353015521C126322002 @default.
• W4353015521 hasConceptScore W4353015521C142724271 @default.
• W4353015521 hasConceptScore W4353015521C143998085 @default.
• W4353015521 hasConceptScore W4353015521C193270364 @default.
• W4353015521 hasConceptScore W4353015521C204232928 @default.
• W4353015521 hasConceptScore W4353015521C2777472916 @default.
• W4353015521 hasConceptScore W4353015521C2778560582 @default.
• W4353015521 hasConceptScore W4353015521C2781278892 @default.
• W4353015521 hasConceptScore W4353015521C502942594 @default.
• W4353015521 hasConceptScore W4353015521C50382708 @default.
• W4353015521 hasConceptScore W4353015521C71924100 @default.
• W4353015521 hasConceptScore W4353015521C86803240 @default.
• W4353015521 hasFunder F4320321491 @default.
• W4353015521 hasIssue "4" @default.
• W4353015521 hasLocation W43530155211 @default.

• next