FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353016822> ?p ?o ?g. }

• W4353016822 abstract "Ebola virus (EBOV) causes a severe infection called Ebola virus disease (EVD). The pathogenesis of EBOV infection is complex, and outcome has been associated with a variety of immunological and cellular factors. Disease can result from several mechanisms, including direct organ and endothelial cell damage as a result of viral replication. During the2013 to 2016 Western Africa EBOV outbreak, several mutants emerged, with changes in the genes of nucleoprotein (NP), glycoprotein (GP), and the large (L) protein. Reverse genetic analysis has been used to investigate whether these mutations played any role in pathogenesis with mixed results depending on the experimental system used. Previous studies investigated the impact of three single nonsynonymous mutations (GP-A82V, NP-R111C, and L-D759G) on the fatality rate of mouse and ferret models and suggested that the L-D759G mutation decreased the virulence of EBOV. In this study, the effect of these three mutations was further evaluated by deep sequencing to determine viral population genetics and the host response in longitudinal samples of blood, liver, kidney, spleen, and lung tissues taken from the previous ferret model. The data indicated that the mutations were maintained in the different tissues, but the frequency of minor genomic mutations were different. In addition, compared to wild-type virus, the recombinant mutants had different within host effects, where the D759G (and accompanying Q986H) substitution in the L protein resulted in an upregulation of the immune response in the kidney, liver, spleen, and lungs. Together these studies provide insights into the biology of EBOV mutants both between and within hosts. IMPORTANCE Ebola virus infection can have dramatic effects on the human body which manifest in Ebola virus disease. The outcome of infection is either survival or death and in the former group with the potential of longer-term health consequences and persistent infection. Disease severity is undoubtedly associated with the host response, often with overt inflammatory responses correlated with poorer outcomes. The scale of the2013 to 2016 Western African Ebola virus outbreak revealed new aspects of viral biology. This included the emergence of mutants with potentially altered virulence. Biobanked tissue from ferret models of EBOV infected with different mutants that emerged in the Western Africa outbreak was used to investigate the effect of EBOV genomic variation in different tissues. Overall, the work provided insights into the population genetics of EBOV and showed that different organs in an animal model can respond differently to variants of EBOV." @default.
• W4353016822 created "2023-03-23" @default.
• W4353016822 creator A5003556936 @default.
• W4353016822 creator A5017805469 @default.
• W4353016822 creator A5021680442 @default.
• W4353016822 creator A5024340967 @default.
• W4353016822 creator A5035892236 @default.
• W4353016822 creator A5041265645 @default.
• W4353016822 creator A5041589783 @default.
• W4353016822 creator A5042560425 @default.
• W4353016822 creator A5067555659 @default.
• W4353016822 creator A5072084139 @default.
• W4353016822 creator A5085318497 @default.
• W4353016822 creator A5090865109 @default.
• W4353016822 date "2023-03-22" @default.
• W4353016822 modified "2023-09-30" @default.
• W4353016822 title "Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes" @default.
• W4353016822 cites W1693165432 @default.
• W4353016822 cites W1966327575 @default.
• W4353016822 cites W1966742128 @default.
• W4353016822 cites W2002206719 @default.
• W4353016822 cites W2035618305 @default.
• W4353016822 cites W2036897871 @default.
• W4353016822 cites W2065256070 @default.
• W4353016822 cites W2102278945 @default.
• W4353016822 cites W2108234281 @default.
• W4353016822 cites W2126548228 @default.
• W4353016822 cites W2131994108 @default.
• W4353016822 cites W2138207763 @default.
• W4353016822 cites W2144619418 @default.
• W4353016822 cites W2152208216 @default.
• W4353016822 cites W2296414617 @default.
• W4353016822 cites W2345513470 @default.
• W4353016822 cites W2399907638 @default.
• W4353016822 cites W2511674367 @default.
• W4353016822 cites W2516104505 @default.
• W4353016822 cites W2546431897 @default.
• W4353016822 cites W2547988744 @default.
• W4353016822 cites W2554344814 @default.
• W4353016822 cites W2579523860 @default.
• W4353016822 cites W2734955935 @default.
• W4353016822 cites W277041599 @default.
• W4353016822 cites W2800487360 @default.
• W4353016822 cites W2896624720 @default.
• W4353016822 cites W2951093541 @default.
• W4353016822 cites W3083900783 @default.
• W4353016822 cites W3085293961 @default.
• W4353016822 cites W3120883989 @default.
• W4353016822 cites W3129414933 @default.
• W4353016822 cites W3159772951 @default.
• W4353016822 cites W3203746373 @default.
• W4353016822 cites W4306318030 @default.
• W4353016822 cites W4322701282 @default.
• W4353016822 doi "https://doi.org/10.1128/spectrum.04154-22" @default.
• W4353016822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36946725" @default.
• W4353016822 hasPublicationYear "2023" @default.
• W4353016822 type Work @default.
• W4353016822 citedByCount "0" @default.
• W4353016822 crossrefType "journal-article" @default.
• W4353016822 hasAuthorship W4353016822A5003556936 @default.
• W4353016822 hasAuthorship W4353016822A5017805469 @default.
• W4353016822 hasAuthorship W4353016822A5021680442 @default.
• W4353016822 hasAuthorship W4353016822A5024340967 @default.
• W4353016822 hasAuthorship W4353016822A5035892236 @default.
• W4353016822 hasAuthorship W4353016822A5041265645 @default.
• W4353016822 hasAuthorship W4353016822A5041589783 @default.
• W4353016822 hasAuthorship W4353016822A5042560425 @default.
• W4353016822 hasAuthorship W4353016822A5067555659 @default.
• W4353016822 hasAuthorship W4353016822A5072084139 @default.
• W4353016822 hasAuthorship W4353016822A5085318497 @default.
• W4353016822 hasAuthorship W4353016822A5090865109 @default.
• W4353016822 hasBestOaLocation W43530168221 @default.
• W4353016822 hasConcept C104317684 @default.
• W4353016822 hasConcept C140704245 @default.
• W4353016822 hasConcept C159047783 @default.
• W4353016822 hasConcept C203014093 @default.
• W4353016822 hasConcept C2522874641 @default.
• W4353016822 hasConcept C2777469322 @default.
• W4353016822 hasConcept C2780931953 @default.
• W4353016822 hasConcept C2908647359 @default.
• W4353016822 hasConcept C2909623084 @default.
• W4353016822 hasConcept C501734568 @default.
• W4353016822 hasConcept C54355233 @default.
• W4353016822 hasConcept C60325843 @default.
• W4353016822 hasConcept C71924100 @default.
• W4353016822 hasConcept C86803240 @default.
• W4353016822 hasConcept C99454951 @default.
• W4353016822 hasConceptScore W4353016822C104317684 @default.
• W4353016822 hasConceptScore W4353016822C140704245 @default.
• W4353016822 hasConceptScore W4353016822C159047783 @default.
• W4353016822 hasConceptScore W4353016822C203014093 @default.
• W4353016822 hasConceptScore W4353016822C2522874641 @default.
• W4353016822 hasConceptScore W4353016822C2777469322 @default.
• W4353016822 hasConceptScore W4353016822C2780931953 @default.
• W4353016822 hasConceptScore W4353016822C2908647359 @default.
• W4353016822 hasConceptScore W4353016822C2909623084 @default.
• W4353016822 hasConceptScore W4353016822C501734568 @default.
• W4353016822 hasConceptScore W4353016822C54355233 @default.
• W4353016822 hasConceptScore W4353016822C60325843 @default.
• W4353016822 hasConceptScore W4353016822C71924100 @default.

• next