FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353018865> ?p ?o ?g. }

• W4353018865 endingPage "1564" @default.
• W4353018865 startingPage "1548" @default.
• W4353018865 abstract "Abstract Antrodia camphorata (AC) and Coenzyme Q 0 (CoQ 0 ), a novel quinone derivative of AC, exhibits antitumor activities. The present study evaluated EMT/metastasis inhibition and autophagy induction aspects of AC and CoQ 0 in human glioblastoma (GBM8401) cells. Our findings revealed that AC treatment (0–150 μg/mL) hindered tumor cell proliferation and migration/invasion in GBM8401 cells. Notably, AC treatment inhibited HIF‐1α and EMT by upregulating epithelial marker protein E‐cadherin while downregulating mesenchymal proteins Twist, Slug, Snail, and β‐catenin. There was an appearance of the autophagy markers LC3‐II and p62/SQSTM1, while ATG4B was downregulated by AC treatment. We also found that CoQ 0 (0–10 μM) could inhibit migration and invasion in GBM8401 cells. In particular, E‐cadherin was elevated and N‐cadherin, Vimentin, Twist, Slug, and Snail, were reduced upon CoQ 0 treatment. In addition, MMP‐2/‐9 expression and Wnt/β‐catenin pathways were downregulated. Furthermore, autophagy inhibitors 3‐MA or CQ reversed the CoQ 0 ‐elicited suppression of migration/invasion and metastasis‐related proteins (Vimentin, Snail, and β‐catenin). Results suggested autophagy‐mediated antiEMT and antimetastasis upon CoQ 0 treatment. CoQ 0 inhibited HIF‐1α and metastasis in GBM8401 cells under normoxia and hypoxia. HIF‐1α knockdown using siRNA accelerated CoQ 0 ‐inhibited migration. Finally, CoQ 0 exhibited a prolonged survival rate in GBM8401‐xenografted mice. Treatment with Antrodia camphorata /CoQ 0 inhibited HIF‐1α and EMT/metastasis in glioblastoma." @default.
• W4353018865 created "2023-03-23" @default.
• W4353018865 creator A5000294922 @default.
• W4353018865 creator A5036623971 @default.
• W4353018865 creator A5038930446 @default.
• W4353018865 creator A5047688182 @default.
• W4353018865 creator A5051258607 @default.
• W4353018865 creator A5056236903 @default.
• W4353018865 creator A5084933751 @default.
• W4353018865 date "2023-03-22" @default.
• W4353018865 modified "2023-10-17" @default.
• W4353018865 title "<i>Antrodia camphorata</i> and coenzyme <scp>Q₀</scp>, a novel quinone derivative of <i>Antrodia camphorata</i>, impede <scp>HIF</scp>‐1α and epithelial‐mesenchymal transition/metastasis in human glioblastoma cells" @default.
• W4353018865 cites W1735670763 @default.
• W4353018865 cites W1963892864 @default.
• W4353018865 cites W1964847767 @default.
• W4353018865 cites W1975034891 @default.
• W4353018865 cites W1977767269 @default.
• W4353018865 cites W1979521500 @default.
• W4353018865 cites W1993098682 @default.
• W4353018865 cites W2007332721 @default.
• W4353018865 cites W2018473844 @default.
• W4353018865 cites W2025647419 @default.
• W4353018865 cites W2030017878 @default.
• W4353018865 cites W2032687345 @default.
• W4353018865 cites W2035396934 @default.
• W4353018865 cites W2036775739 @default.
• W4353018865 cites W2038055424 @default.
• W4353018865 cites W2051511388 @default.
• W4353018865 cites W2055728184 @default.
• W4353018865 cites W2073965305 @default.
• W4353018865 cites W2080421381 @default.
• W4353018865 cites W2093921289 @default.
• W4353018865 cites W2100592123 @default.
• W4353018865 cites W2101466169 @default.
• W4353018865 cites W2107648723 @default.
• W4353018865 cites W2110128697 @default.
• W4353018865 cites W2115833310 @default.
• W4353018865 cites W2119630390 @default.
• W4353018865 cites W2126409614 @default.
• W4353018865 cites W2132703168 @default.
• W4353018865 cites W2134421488 @default.
• W4353018865 cites W2142928449 @default.
• W4353018865 cites W2157474530 @default.
• W4353018865 cites W2194719895 @default.
• W4353018865 cites W2197713588 @default.
• W4353018865 cites W2219742274 @default.
• W4353018865 cites W2258531487 @default.
• W4353018865 cites W2295029973 @default.
• W4353018865 cites W2513393093 @default.
• W4353018865 cites W2517084468 @default.
• W4353018865 cites W2536431286 @default.
• W4353018865 cites W2553316467 @default.
• W4353018865 cites W2626824598 @default.
• W4353018865 cites W2728052031 @default.
• W4353018865 cites W2739191486 @default.
• W4353018865 cites W2747922468 @default.
• W4353018865 cites W2774797293 @default.
• W4353018865 cites W2775267837 @default.
• W4353018865 cites W2792139654 @default.
• W4353018865 cites W2810736917 @default.
• W4353018865 cites W2890770499 @default.
• W4353018865 cites W2892476927 @default.
• W4353018865 cites W2900649277 @default.
• W4353018865 cites W2905479983 @default.
• W4353018865 cites W2946899700 @default.
• W4353018865 cites W2992985193 @default.
• W4353018865 cites W3015714049 @default.
• W4353018865 cites W3031649227 @default.
• W4353018865 cites W3048393735 @default.
• W4353018865 cites W3091796375 @default.
• W4353018865 cites W3112281175 @default.
• W4353018865 cites W3137429091 @default.
• W4353018865 cites W3161256262 @default.
• W4353018865 cites W3163297994 @default.
• W4353018865 cites W3180913586 @default.
• W4353018865 cites W3199439965 @default.
• W4353018865 cites W4211212920 @default.
• W4353018865 cites W4283318274 @default.
• W4353018865 cites W4296693425 @default.
• W4353018865 cites W4298087665 @default.
• W4353018865 doi "https://doi.org/10.1002/tox.23785" @default.
• W4353018865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36947447" @default.
• W4353018865 hasPublicationYear "2023" @default.
• W4353018865 type Work @default.
• W4353018865 citedByCount "0" @default.
• W4353018865 crossrefType "journal-article" @default.
• W4353018865 hasAuthorship W4353018865A5000294922 @default.
• W4353018865 hasAuthorship W4353018865A5036623971 @default.
• W4353018865 hasAuthorship W4353018865A5038930446 @default.
• W4353018865 hasAuthorship W4353018865A5047688182 @default.
• W4353018865 hasAuthorship W4353018865A5051258607 @default.
• W4353018865 hasAuthorship W4353018865A5056236903 @default.
• W4353018865 hasAuthorship W4353018865A5084933751 @default.
• W4353018865 hasConcept C121608353 @default.
• W4353018865 hasConcept C137620995 @default.
• W4353018865 hasConcept C147447768 @default.
• W4353018865 hasConcept C173396325 @default.
• W4353018865 hasConcept C185592680 @default.

• next