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• W4353042449 abstract "Background Obesity is associated with more severe asthma, however, the mechanisms responsible are poorly understood. Obesity is also associated with low-grade systemic inflammation; it is possible that this inflammation extends to the airways of adults with asthma, contributing to worse asthma outcomes. Accordingly, the aim of this review was to examine whether obesity is associated with increased airway and systemic inflammation and adipokines, in adults with asthma. Methods Medline, Embase, CINAHL, Scopus and Current Contents were searched till 11 August 2021. Studies reporting measures of airway inflammation, systemic inflammation and/or adipokines in obese versus non-obese adults with asthma were assessed. We conducted random effects meta-analyses. We assessed heterogeneity using the I 2 statistic and publication bias using funnel plots. Results We included 40 studies in the meta-analysis. Sputum neutrophils were 5% higher in obese versus non-obese asthmatics (mean difference (MD)=5.0%, 95% CI: 1.2 to 8.9, n=2297, p=0.01, I 2 =42%). Blood neutrophil count was also higher in obesity. There was no difference in sputum %eosinophils; however, bronchial submucosal eosinophil count (standardised mean difference (SMD)=0.58, 95% CI=0.25 to 0.91, p<0.001, n=181, I 2 =0%) and sputum interleukin 5 (IL-5) (SMD=0.46, 95% CI=0.17 to 0.75, p<0.002, n=198, I 2 =0%) were higher in obesity. Conversely, fractional exhaled nitric oxide was 4.5 ppb lower in obesity (MD=−4.5 ppb, 95% CI=−7.1 ppb to −1.8 ppb, p<0.001, n=2601, I 2 =40%). Blood C reactive protein, IL-6 and leptin were also higher in obesity. Conclusions Obese asthmatics have a different pattern of inflammation to non-obese asthmatics. Mechanistic studies examining the pattern of inflammation in obese asthmatics are warranted. Studies should also investigate the clinical relevance of this altered inflammatory response. PROSPERO registeration number CRD42021254525." @default.
• W4353042449 created "2023-03-23" @default.
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• W4353042449 date "2023-03-22" @default.
• W4353042449 modified "2023-10-16" @default.
• W4353042449 title "Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis" @default.
• W4353042449 cites W1212629052 @default.
• W4353042449 cites W1500938043 @default.
• W4353042449 cites W1521832823 @default.
• W4353042449 cites W1534181333 @default.
• W4353042449 cites W1709740668 @default.
• W4353042449 cites W1790363228 @default.
• W4353042449 cites W1971440323 @default.
• W4353042449 cites W1972801677 @default.
• W4353042449 cites W1979022638 @default.
• W4353042449 cites W1979077222 @default.
• W4353042449 cites W1979423827 @default.
• W4353042449 cites W1986400684 @default.
• W4353042449 cites W1989626763 @default.
• W4353042449 cites W1992987825 @default.
• W4353042449 cites W2003900544 @default.
• W4353042449 cites W2010530108 @default.
• W4353042449 cites W2015120203 @default.
• W4353042449 cites W2020676062 @default.
• W4353042449 cites W2024298163 @default.
• W4353042449 cites W2036894863 @default.
• W4353042449 cites W2040951215 @default.
• W4353042449 cites W2045004105 @default.
• W4353042449 cites W2057142554 @default.
• W4353042449 cites W2069530450 @default.
• W4353042449 cites W2076702746 @default.
• W4353042449 cites W2078900153 @default.
• W4353042449 cites W2088102919 @default.
• W4353042449 cites W2089873166 @default.
• W4353042449 cites W2094330927 @default.
• W4353042449 cites W2097066928 @default.
• W4353042449 cites W2100560329 @default.
• W4353042449 cites W2106715003 @default.
• W4353042449 cites W2110407409 @default.
• W4353042449 cites W2115711076 @default.
• W4353042449 cites W2119605658 @default.
• W4353042449 cites W2119715664 @default.
• W4353042449 cites W2124131572 @default.
• W4353042449 cites W2125435699 @default.
• W4353042449 cites W2132919605 @default.
• W4353042449 cites W2134773259 @default.
• W4353042449 cites W2143666217 @default.
• W4353042449 cites W2147991740 @default.
• W4353042449 cites W2148477057 @default.
• W4353042449 cites W2157823046 @default.
• W4353042449 cites W2158079900 @default.
• W4353042449 cites W2167378896 @default.
• W4353042449 cites W2168186403 @default.
• W4353042449 cites W2170892587 @default.
• W4353042449 cites W2188422973 @default.
• W4353042449 cites W2307816995 @default.
• W4353042449 cites W2338752053 @default.
• W4353042449 cites W2460847010 @default.
• W4353042449 cites W2467256079 @default.
• W4353042449 cites W2473370573 @default.
• W4353042449 cites W2507173059 @default.
• W4353042449 cites W2542670633 @default.
• W4353042449 cites W2592154888 @default.
• W4353042449 cites W2593240146 @default.
• W4353042449 cites W2606264751 @default.
• W4353042449 cites W2623650805 @default.
• W4353042449 cites W2625404272 @default.
• W4353042449 cites W2626318976 @default.
• W4353042449 cites W2684049278 @default.
• W4353042449 cites W2736849682 @default.
• W4353042449 cites W2742282263 @default.
• W4353042449 cites W2750514737 @default.
• W4353042449 cites W2761368863 @default.
• W4353042449 cites W2774854768 @default.
• W4353042449 cites W2806742155 @default.
• W4353042449 cites W2883429041 @default.
• W4353042449 cites W2885211253 @default.
• W4353042449 cites W2886784996 @default.
• W4353042449 cites W2898256930 @default.
• W4353042449 cites W2907436604 @default.
• W4353042449 cites W2939247829 @default.
• W4353042449 cites W2965570717 @default.
• W4353042449 cites W2971947803 @default.
• W4353042449 cites W2990456080 @default.
• W4353042449 cites W2994839185 @default.
• W4353042449 cites W3019177863 @default.
• W4353042449 cites W3036368019 @default.
• W4353042449 cites W3047175333 @default.
• W4353042449 cites W3096498763 @default.
• W4353042449 cites W3164492200 @default.

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