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- W4353046757 abstract "Pelviureteric junction obstruction (PUJO) is one of the most common causes of hydronephrosis in children. If not treated in a timely manner, it can result in complete loss of the kidney. PUJO is usually a congenital condition, secondary to a disturbance in the peristaltic activity of the ureter, due to abnormal smooth muscle arrangements in the proximal ureteric wall [ [1] Al Aaraj M.S. Badreldin A.M. Ureteropelvic junction obstruction. in: StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL)2022 Jul 11https://www.ncbi.nlm.nih.gov/books/NBK560740/ Google Scholar ]. Hydronephrosis develops first as a protective anatomic response. But if severe stenosis persists renal damage occurs as a functional response [ [2] Onen A. Grading of hydronephrosis: an ongoing challenge. Front Pediatr. 2020 Aug 27; 8: 458https://doi:10.3389/fped.2020.00458 Crossref PubMed Scopus (37) Google Scholar ]. Severe hydronephrosis causes parenchymal loss and cortical damage leading to decreased glomerular filtration and renal function, because of tubular atrophy and interstitial inflammation. The number of nephrons decreases, renal maturation is affected, and renal failure occurs. Response to commentary re clues for the early loss of renal function in congenital hydronephrosis: Analysis of renal pelvis collagen ratio, diuresis renography and upper urinary tract morphologyJournal of Pediatric UrologyVol. 19Issue 4PreviewDiagnosis of urinary obstruction and surgical decision making for the operative correction of urinary obstruction in congenital hydronephrosis are challenging. Histopathological studies in these cases are focused mostly on the renal parenchyma and the ureteropelvic junction. Although dilatation of renal pelvis has been accepted to work as a renal parenchymal protection mechanism, renal pelvic dilatation cannot accomplish this task in a rare group of cases. Progressive and rapid loss of function is encountered in this rare group of cases. Full-Text PDF" @default.
- W4353046757 created "2023-03-23" @default.
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- W4353046757 date "2023-08-01" @default.
- W4353046757 modified "2023-09-25" @default.
- W4353046757 title "Commentary to Clues for the early loss of renal function in congenital hydronephrosis: Analysis of renal pelvis collagen ratio, diuresis renography and upper urinary tract morphology" @default.
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- W4353046757 doi "https://doi.org/10.1016/j.jpurol.2023.03.016" @default.
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