Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353050175> ?p ?o ?g. }
- W4353050175 endingPage "426" @default.
- W4353050175 startingPage "418" @default.
- W4353050175 abstract "This study aimed to evaluate a potential relationship between the diffusing capacity of the lung for carbon monoxide (DLCO) and the aggressiveness of lung adenocarcinoma (ADC).Patients who underwent radical surgery for lung ADC between 2001 and 2018 were retrospectively reviewed. DLCO values were dichotomized into DLCOlow (<80% of predicted) and DLCOnormal (≥80%). Relationships between DLCO and ADC histopathological features, clinical features, as well as with overall survival (OS), were evaluated.Four-hundred and sixty patients were enrolled, of which 193 (42%) were included in the DLCOlow group. DLCOlow was associated with smoking status, low FEV1, micropapillary and solid ADC, tumour grade 3, high tumour lymphoid infiltrate and presence of tumour desmoplasia. In addition, DLCO values were higher in low-grade ADC and progressively decreased in intermediate and high-grade ADC (p=0.024). After adjusting for clinical variables, at multivariable logistic regression analysis, DLCOlow still showed a significant correlation with high lymphoid infiltrate (p=0.017), presence of desmoplasia (p=0.065), tumour grade 3 (p=0.062), micropapillary and solid ADC subtypes (p=0.008). To exclude the association between non-smokers and well-differentiated ADC, the relationship between DLCO and histopathological ADC patterns was confirmed in the subset of 377 former and current smokers (p=0.021). At univariate analysis, gender, DLCO, FEV1, ADC histotype, tumour grade, stage, pleural invasion, tumour necrosis, tumour desmoplasia, lymphatic and blood invasion were significantly related with OS. At multivariate analysis, only gender (p<0.001), tumour stage (p<0.001) and DLCO (p=0.050) were significantly related with the OS.We found a relationship between DLCO and ADC patterns as well as with tumour grade, tumour lymphoid infiltrate and desmoplasia, suggesting that lung damage may be associated with tumour aggressiveness." @default.
- W4353050175 created "2023-03-23" @default.
- W4353050175 creator A5004507388 @default.
- W4353050175 creator A5012454543 @default.
- W4353050175 creator A5012656284 @default.
- W4353050175 creator A5016024318 @default.
- W4353050175 creator A5027025470 @default.
- W4353050175 creator A5037329218 @default.
- W4353050175 creator A5040557811 @default.
- W4353050175 creator A5046091862 @default.
- W4353050175 creator A5050335373 @default.
- W4353050175 creator A5059211689 @default.
- W4353050175 creator A5067835080 @default.
- W4353050175 creator A5071783009 @default.
- W4353050175 creator A5072678466 @default.
- W4353050175 creator A5077096170 @default.
- W4353050175 creator A5084167254 @default.
- W4353050175 creator A5090079931 @default.
- W4353050175 creator A5090482255 @default.
- W4353050175 date "2023-07-01" @default.
- W4353050175 modified "2023-09-26" @default.
- W4353050175 title "Relationship Between the Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) and Lung Adenocarcinoma Patterns: New Possible Insights" @default.
- W4353050175 cites W1517652155 @default.
- W4353050175 cites W1974084284 @default.
- W4353050175 cites W1978389571 @default.
- W4353050175 cites W1990324485 @default.
- W4353050175 cites W1993324234 @default.
- W4353050175 cites W1993807667 @default.
- W4353050175 cites W2008036272 @default.
- W4353050175 cites W2008662050 @default.
- W4353050175 cites W2014249323 @default.
- W4353050175 cites W2015537995 @default.
- W4353050175 cites W2032995263 @default.
- W4353050175 cites W2034346990 @default.
- W4353050175 cites W2044805007 @default.
- W4353050175 cites W2049674541 @default.
- W4353050175 cites W2106304024 @default.
- W4353050175 cites W2112884668 @default.
- W4353050175 cites W2124879124 @default.
- W4353050175 cites W2126215220 @default.
- W4353050175 cites W2137991156 @default.
- W4353050175 cites W2163149604 @default.
- W4353050175 cites W2167043905 @default.
- W4353050175 cites W2170690118 @default.
- W4353050175 cites W2228221433 @default.
- W4353050175 cites W2251438188 @default.
- W4353050175 cites W2410543196 @default.
- W4353050175 cites W2616383576 @default.
- W4353050175 cites W2770262779 @default.
- W4353050175 cites W2783780270 @default.
- W4353050175 cites W3014529371 @default.
- W4353050175 cites W3046307945 @default.
- W4353050175 cites W3102213105 @default.
- W4353050175 cites W3170194338 @default.
- W4353050175 doi "https://doi.org/10.1016/j.arbres.2023.03.015" @default.
- W4353050175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37032196" @default.
- W4353050175 hasPublicationYear "2023" @default.
- W4353050175 type Work @default.
- W4353050175 citedByCount "0" @default.
- W4353050175 crossrefType "journal-article" @default.
- W4353050175 hasAuthorship W4353050175A5004507388 @default.
- W4353050175 hasAuthorship W4353050175A5012454543 @default.
- W4353050175 hasAuthorship W4353050175A5012656284 @default.
- W4353050175 hasAuthorship W4353050175A5016024318 @default.
- W4353050175 hasAuthorship W4353050175A5027025470 @default.
- W4353050175 hasAuthorship W4353050175A5037329218 @default.
- W4353050175 hasAuthorship W4353050175A5040557811 @default.
- W4353050175 hasAuthorship W4353050175A5046091862 @default.
- W4353050175 hasAuthorship W4353050175A5050335373 @default.
- W4353050175 hasAuthorship W4353050175A5059211689 @default.
- W4353050175 hasAuthorship W4353050175A5067835080 @default.
- W4353050175 hasAuthorship W4353050175A5071783009 @default.
- W4353050175 hasAuthorship W4353050175A5072678466 @default.
- W4353050175 hasAuthorship W4353050175A5077096170 @default.
- W4353050175 hasAuthorship W4353050175A5084167254 @default.
- W4353050175 hasAuthorship W4353050175A5090079931 @default.
- W4353050175 hasAuthorship W4353050175A5090482255 @default.
- W4353050175 hasBestOaLocation W43530501751 @default.
- W4353050175 hasConcept C121608353 @default.
- W4353050175 hasConcept C126322002 @default.
- W4353050175 hasConcept C126838900 @default.
- W4353050175 hasConcept C142724271 @default.
- W4353050175 hasConcept C144301174 @default.
- W4353050175 hasConcept C16020263 @default.
- W4353050175 hasConcept C165637977 @default.
- W4353050175 hasConcept C2777714996 @default.
- W4353050175 hasConcept C2780210213 @default.
- W4353050175 hasConcept C2781005279 @default.
- W4353050175 hasConcept C2781182431 @default.
- W4353050175 hasConcept C3018587741 @default.
- W4353050175 hasConcept C38180746 @default.
- W4353050175 hasConcept C71924100 @default.
- W4353050175 hasConcept C90924648 @default.
- W4353050175 hasConceptScore W4353050175C121608353 @default.
- W4353050175 hasConceptScore W4353050175C126322002 @default.
- W4353050175 hasConceptScore W4353050175C126838900 @default.
- W4353050175 hasConceptScore W4353050175C142724271 @default.
- W4353050175 hasConceptScore W4353050175C144301174 @default.