Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353055669> ?p ?o ?g. }
- W4353055669 endingPage "122876" @default.
- W4353055669 startingPage "122876" @default.
- W4353055669 abstract "Cyclodextrin (CD) is used to solubilize poorly water-soluble drugs by inclusion complex formation. In this study, we investigated the effect of CD derivatives on stabilizing the supersaturation by inhibiting the crystallization of two poorly water-soluble drugs, carvedilol (CVD) and chlorthalidone (CLT). The phase solubility test showed that β-CD and γ-CD derivatives enhanced the solubility of CVD to a greater extent, whereas the solubility of CLT was enhanced more by β-CD derivatives. The solubilization efficacy of CD derivatives was dependent on the size fitness between the drug molecule and the CD cavity. In the drug crystallization induction time measurement, the same initial drug supersaturation ratio (S) was employed in all the CD solutions, and the methylated CD derivatives greatly outperformed unmethylated CD derivatives in stabilizing the supersaturation of both CVD and CLT. The crystallization inhibition strength of CD derivatives was strongly affected by the CD derivative substituent. Moreover, the calculated logarithm of octanol/water partition coefficients (log P) of CD derivatives showed a good correlation with drug crystallization inhibition ability. Thus, the high hydrophobicity of methylated CD plays an essential role in inhibiting crystallization. These findings can provide a valuable guide for selecting appropriate stabilizing agents for drug-supersaturation formulations." @default.
- W4353055669 created "2023-03-23" @default.
- W4353055669 creator A5021680466 @default.
- W4353055669 creator A5050214000 @default.
- W4353055669 creator A5057401220 @default.
- W4353055669 creator A5090660967 @default.
- W4353055669 date "2023-04-01" @default.
- W4353055669 modified "2023-10-14" @default.
- W4353055669 title "Supersaturation maintenance of carvedilol and chlorthalidone by cyclodextrin derivatives: Pronounced crystallization inhibition ability of methylated cyclodextrin" @default.
- W4353055669 cites W1870101566 @default.
- W4353055669 cites W1979847090 @default.
- W4353055669 cites W1983270213 @default.
- W4353055669 cites W1985084738 @default.
- W4353055669 cites W1996776705 @default.
- W4353055669 cites W1998083552 @default.
- W4353055669 cites W2001533174 @default.
- W4353055669 cites W2001899961 @default.
- W4353055669 cites W2003080384 @default.
- W4353055669 cites W2014428322 @default.
- W4353055669 cites W2015706463 @default.
- W4353055669 cites W2036437067 @default.
- W4353055669 cites W2036442936 @default.
- W4353055669 cites W2038334243 @default.
- W4353055669 cites W2039300758 @default.
- W4353055669 cites W2039579537 @default.
- W4353055669 cites W2044609602 @default.
- W4353055669 cites W2068184869 @default.
- W4353055669 cites W2069706601 @default.
- W4353055669 cites W2070406363 @default.
- W4353055669 cites W2072315516 @default.
- W4353055669 cites W2077548169 @default.
- W4353055669 cites W2086382785 @default.
- W4353055669 cites W2088423553 @default.
- W4353055669 cites W2089275624 @default.
- W4353055669 cites W2128367206 @default.
- W4353055669 cites W2131011009 @default.
- W4353055669 cites W2143259994 @default.
- W4353055669 cites W2163422568 @default.
- W4353055669 cites W2167659076 @default.
- W4353055669 cites W2253675932 @default.
- W4353055669 cites W2293448613 @default.
- W4353055669 cites W2304404543 @default.
- W4353055669 cites W2318209581 @default.
- W4353055669 cites W2328474694 @default.
- W4353055669 cites W2460711108 @default.
- W4353055669 cites W2461486116 @default.
- W4353055669 cites W2475322761 @default.
- W4353055669 cites W2515837249 @default.
- W4353055669 cites W2532969571 @default.
- W4353055669 cites W2760466791 @default.
- W4353055669 cites W2767842869 @default.
- W4353055669 cites W2795451955 @default.
- W4353055669 cites W2800612483 @default.
- W4353055669 cites W2866313492 @default.
- W4353055669 cites W2900186234 @default.
- W4353055669 cites W2939557061 @default.
- W4353055669 cites W2955461563 @default.
- W4353055669 cites W2971332552 @default.
- W4353055669 cites W298267720 @default.
- W4353055669 cites W2987163821 @default.
- W4353055669 cites W2996576105 @default.
- W4353055669 cites W3105169712 @default.
- W4353055669 cites W3114404685 @default.
- W4353055669 cites W3177061949 @default.
- W4353055669 cites W3206677778 @default.
- W4353055669 cites W3207403541 @default.
- W4353055669 cites W4210800713 @default.
- W4353055669 cites W4283387763 @default.
- W4353055669 doi "https://doi.org/10.1016/j.ijpharm.2023.122876" @default.
- W4353055669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36963642" @default.
- W4353055669 hasPublicationYear "2023" @default.
- W4353055669 type Work @default.
- W4353055669 citedByCount "1" @default.
- W4353055669 countsByYear W43530556692023 @default.
- W4353055669 crossrefType "journal-article" @default.
- W4353055669 hasAuthorship W4353055669A5021680466 @default.
- W4353055669 hasAuthorship W4353055669A5050214000 @default.
- W4353055669 hasAuthorship W4353055669A5057401220 @default.
- W4353055669 hasAuthorship W4353055669A5090660967 @default.
- W4353055669 hasConcept C13965031 @default.
- W4353055669 hasConcept C155574463 @default.
- W4353055669 hasConcept C178790620 @default.
- W4353055669 hasConcept C185592680 @default.
- W4353055669 hasConcept C192552737 @default.
- W4353055669 hasConcept C200447597 @default.
- W4353055669 hasConcept C203036418 @default.
- W4353055669 hasConcept C2779433975 @default.
- W4353055669 hasConcept C2779918671 @default.
- W4353055669 hasConcept C2780427769 @default.
- W4353055669 hasConcept C43617362 @default.
- W4353055669 hasConcept C71924100 @default.
- W4353055669 hasConcept C88380143 @default.
- W4353055669 hasConcept C98274493 @default.
- W4353055669 hasConceptScore W4353055669C13965031 @default.
- W4353055669 hasConceptScore W4353055669C155574463 @default.
- W4353055669 hasConceptScore W4353055669C178790620 @default.
- W4353055669 hasConceptScore W4353055669C185592680 @default.
- W4353055669 hasConceptScore W4353055669C192552737 @default.