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- W4353056900 abstract "Six undescribed macrocyclic daphnane orthoesters, stelleratenoids A−F (1−6), were isolated from the roots of Stellera chamaejasme L. Their structures were elucidated by extensive spectroscopic analyses, including HRESIMS and NMR spectra. Compound 1 features an unusual terminal double bond at C-2/C-19 in the 1α-alkyldaphnane lactone skeleton. Compounds 2−4 are unique in the presence of different long chain fatty acyl groups. Compounds 5 and 6 are unique examples of modified macrocyclic daphnane diterpenoids. All the isolates were evaluated for anti-HIV activity in MT-2 cells. Among them, compounds 1, 5 and 6 exhibited highly potent anti-HIV activity with EC50 values of 66.70, 10.62 and 55.10 nM, respectively, possessing high potential to develop new anti-HIV drugs." @default.
- W4353056900 created "2023-03-23" @default.
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- W4353056900 date "2023-06-01" @default.
- W4353056900 modified "2023-09-22" @default.
- W4353056900 title "Stelleratenoids A−F, macrocyclic daphnane orthoesters with anti-HIV activity from the roots of Stellera chamaejasme L." @default.
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- W4353056900 doi "https://doi.org/10.1016/j.phytochem.2023.113648" @default.
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