Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353067650> ?p ?o ?g. }
- W4353067650 endingPage "770" @default.
- W4353067650 startingPage "770" @default.
- W4353067650 abstract "Inflammation is the body's response to insults, for instance, lung inflammation is generally caused by pathogens or by exposure to pollutants, irritants and toxins. This process involves many inflammatory cells such as epithelial cells, monocytes, macrophages and neutrophils. These cells produce and release inflammatory mediators such as pro-inflammatory cytokines, lipids and reactive oxygen species (ROS). Lung epithelial cells and phagocytes (monocytes, macrophages and neutrophils) produce ROS mainly by the NADPH oxidase NOX1 and NOX2, respectively. The aim of this study was to investigate the effects of two NADPH oxidase inhibitors, apocynin and diphenyleneiodonium (DPI), on lipopolysaccharide (LPS)-induced lung inflammation in rats. Our results showed that apocynin and DPI attenuated the LPS-induced morphological and histological alterations of the lung, reduced edema and decreased lung permeability. The evaluation of oxidative stress markers in lung homogenates showed that apocynin and DPI inhibited LPS-induced NADPH oxidase activity, and restored superoxide dismutase (SOD) and catalase activity in the lung resulting in the reduction in LPS-induced protein and lipid oxidation. Additionally, apocynin and DPI decreased LPS-induced MPO activity in bronchoalveolar liquid and lung homogenates, TNF-α and IL-1β in rat plasma. NADPH oxidase inhibition could be a new therapeutic strategy for the treatment of inflammatory lung diseases." @default.
- W4353067650 created "2023-03-23" @default.
- W4353067650 creator A5014280478 @default.
- W4353067650 creator A5025637625 @default.
- W4353067650 creator A5038203805 @default.
- W4353067650 creator A5063072620 @default.
- W4353067650 creator A5067267143 @default.
- W4353067650 creator A5067981758 @default.
- W4353067650 creator A5069269884 @default.
- W4353067650 date "2023-03-21" @default.
- W4353067650 modified "2023-09-30" @default.
- W4353067650 title "The NADPH Oxidase Inhibitors Apocynin and Diphenyleneiodonium Protect Rats from LPS-Induced Pulmonary Inflammation" @default.
- W4353067650 cites W1538527390 @default.
- W4353067650 cites W1582348132 @default.
- W4353067650 cites W1600560134 @default.
- W4353067650 cites W1736337862 @default.
- W4353067650 cites W1750690213 @default.
- W4353067650 cites W1775749144 @default.
- W4353067650 cites W1801129364 @default.
- W4353067650 cites W1913376392 @default.
- W4353067650 cites W191793640 @default.
- W4353067650 cites W1957404430 @default.
- W4353067650 cites W1965729203 @default.
- W4353067650 cites W1967874462 @default.
- W4353067650 cites W1976108411 @default.
- W4353067650 cites W1980429825 @default.
- W4353067650 cites W1989713074 @default.
- W4353067650 cites W1999644843 @default.
- W4353067650 cites W2002831774 @default.
- W4353067650 cites W2004658544 @default.
- W4353067650 cites W2016575029 @default.
- W4353067650 cites W2024861912 @default.
- W4353067650 cites W2032397591 @default.
- W4353067650 cites W2042641359 @default.
- W4353067650 cites W2063140554 @default.
- W4353067650 cites W2073607297 @default.
- W4353067650 cites W2074841172 @default.
- W4353067650 cites W2078711199 @default.
- W4353067650 cites W2083750707 @default.
- W4353067650 cites W2085586322 @default.
- W4353067650 cites W2096869450 @default.
- W4353067650 cites W2116965731 @default.
- W4353067650 cites W2118538670 @default.
- W4353067650 cites W2131518920 @default.
- W4353067650 cites W2135637410 @default.
- W4353067650 cites W2147243248 @default.
- W4353067650 cites W2148000616 @default.
- W4353067650 cites W2486304685 @default.
- W4353067650 cites W2507370326 @default.
- W4353067650 cites W2620241325 @default.
- W4353067650 cites W2763440710 @default.
- W4353067650 cites W2895130115 @default.
- W4353067650 cites W2956481235 @default.
- W4353067650 cites W3002195589 @default.
- W4353067650 cites W3020992950 @default.
- W4353067650 cites W3035506713 @default.
- W4353067650 cites W3047284551 @default.
- W4353067650 doi "https://doi.org/10.3390/antiox12030770" @default.
- W4353067650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36979018" @default.
- W4353067650 hasPublicationYear "2023" @default.
- W4353067650 type Work @default.
- W4353067650 citedByCount "2" @default.
- W4353067650 countsByYear W43530676502023 @default.
- W4353067650 crossrefType "journal-article" @default.
- W4353067650 hasAuthorship W4353067650A5014280478 @default.
- W4353067650 hasAuthorship W4353067650A5025637625 @default.
- W4353067650 hasAuthorship W4353067650A5038203805 @default.
- W4353067650 hasAuthorship W4353067650A5063072620 @default.
- W4353067650 hasAuthorship W4353067650A5067267143 @default.
- W4353067650 hasAuthorship W4353067650A5067981758 @default.
- W4353067650 hasAuthorship W4353067650A5069269884 @default.
- W4353067650 hasBestOaLocation W43530676501 @default.
- W4353067650 hasConcept C126322002 @default.
- W4353067650 hasConcept C181199279 @default.
- W4353067650 hasConcept C185592680 @default.
- W4353067650 hasConcept C203014093 @default.
- W4353067650 hasConcept C2775838275 @default.
- W4353067650 hasConcept C2776061955 @default.
- W4353067650 hasConcept C2776151105 @default.
- W4353067650 hasConcept C2776914184 @default.
- W4353067650 hasConcept C2777209548 @default.
- W4353067650 hasConcept C2777714996 @default.
- W4353067650 hasConcept C2777961210 @default.
- W4353067650 hasConcept C2778754761 @default.
- W4353067650 hasConcept C2778979269 @default.
- W4353067650 hasConcept C2779719074 @default.
- W4353067650 hasConcept C2780795997 @default.
- W4353067650 hasConcept C48349386 @default.
- W4353067650 hasConcept C55493867 @default.
- W4353067650 hasConcept C71924100 @default.
- W4353067650 hasConcept C86803240 @default.
- W4353067650 hasConcept C98274493 @default.
- W4353067650 hasConceptScore W4353067650C126322002 @default.
- W4353067650 hasConceptScore W4353067650C181199279 @default.
- W4353067650 hasConceptScore W4353067650C185592680 @default.
- W4353067650 hasConceptScore W4353067650C203014093 @default.
- W4353067650 hasConceptScore W4353067650C2775838275 @default.
- W4353067650 hasConceptScore W4353067650C2776061955 @default.