Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353069342> ?p ?o ?g. }
- W4353069342 endingPage "475" @default.
- W4353069342 startingPage "475" @default.
- W4353069342 abstract "Calcitonin gene-related peptide (CGRP), an endogenous neuropeptide released from perivascular sensory nerves, exerts a powerful vasodilatation. Interestingly, adenosine triphosphate (ATP) stimulates the release of CGRP by activation of prejunctional P2X2/3 receptors, and adenosine 5′-O-2-thiodiphosphate (ADPβS), a stable adenosine diphosphate (ADP) analogue, produces vasodilator/vasodepressor responses by endothelial P2Y1 receptors. Since the role of ADP in the prejunctional modulation of the vasodepressor sensory CGRPergic drive and the receptors involved remain unknown, this study investigated whether ADPβS inhibits this CGRPergic drive. Accordingly, 132 male Wistar rats were pithed and subsequently divided into two sets. In set 1, ADPβS (5.6 and 10 µg/kg·min) inhibited the vasodepressor CGRPergic responses by electrical stimulation of the spinal T9–T12 segment. This inhibition by ADPβS (5.6 µg/kg·min) was reverted after i.v. administration of the purinergic antagonists MRS2500 (300 µg/kg; P2Y1) or MRS2211 (3000 µg/kg; P2Y13), but not by PSB0739 (300 µg/kg; P2Y12), MRS2211 (1000 µg/kg; P2Y13) or the KATP blocker glibenclamide (20 mg/kg). In set 2, ADPβS (5.6 µg/kg·min) failed to modify the vasodepressor responses to exogenous α-CGRP. These results suggest that ADPβS inhibits CGRP release in perivascular sensory nerves. This inhibition, apparently unrelated to activation of ATP-sensitive K+ channels, involves P2Y1 and probably P2Y13, but not P2Y12 receptors." @default.
- W4353069342 created "2023-03-23" @default.
- W4353069342 creator A5004685852 @default.
- W4353069342 creator A5005798420 @default.
- W4353069342 creator A5026439229 @default.
- W4353069342 creator A5065822424 @default.
- W4353069342 creator A5078543779 @default.
- W4353069342 creator A5085116945 @default.
- W4353069342 date "2023-03-22" @default.
- W4353069342 modified "2023-09-30" @default.
- W4353069342 title "Pharmacological Profile of the Purinergic P2Y Receptors That Modulate, in Response to ADPβS, the Vasodepressor Sensory CGRPergic Outflow in Pithed Rats" @default.
- W4353069342 cites W1488329806 @default.
- W4353069342 cites W1506673182 @default.
- W4353069342 cites W1523338753 @default.
- W4353069342 cites W1588230966 @default.
- W4353069342 cites W1916800927 @default.
- W4353069342 cites W1965982516 @default.
- W4353069342 cites W1970487416 @default.
- W4353069342 cites W1971835658 @default.
- W4353069342 cites W1972059769 @default.
- W4353069342 cites W1980677863 @default.
- W4353069342 cites W1980896071 @default.
- W4353069342 cites W1985927027 @default.
- W4353069342 cites W1990501950 @default.
- W4353069342 cites W1990819931 @default.
- W4353069342 cites W1995810932 @default.
- W4353069342 cites W1996973353 @default.
- W4353069342 cites W2000989410 @default.
- W4353069342 cites W2001650386 @default.
- W4353069342 cites W2004674974 @default.
- W4353069342 cites W2010916378 @default.
- W4353069342 cites W2012359547 @default.
- W4353069342 cites W2014687654 @default.
- W4353069342 cites W2021252502 @default.
- W4353069342 cites W2022658237 @default.
- W4353069342 cites W2037546544 @default.
- W4353069342 cites W2041904720 @default.
- W4353069342 cites W2041987144 @default.
- W4353069342 cites W2042885920 @default.
- W4353069342 cites W2043176796 @default.
- W4353069342 cites W2043739441 @default.
- W4353069342 cites W2048201868 @default.
- W4353069342 cites W2052385273 @default.
- W4353069342 cites W2052534560 @default.
- W4353069342 cites W2053277833 @default.
- W4353069342 cites W2054924316 @default.
- W4353069342 cites W2057684472 @default.
- W4353069342 cites W2057960709 @default.
- W4353069342 cites W2063605858 @default.
- W4353069342 cites W2077018229 @default.
- W4353069342 cites W2077528102 @default.
- W4353069342 cites W2079067713 @default.
- W4353069342 cites W2085595272 @default.
- W4353069342 cites W2086394203 @default.
- W4353069342 cites W2087729796 @default.
- W4353069342 cites W2099757747 @default.
- W4353069342 cites W2100799786 @default.
- W4353069342 cites W2103044440 @default.
- W4353069342 cites W2111112233 @default.
- W4353069342 cites W2117154038 @default.
- W4353069342 cites W2125001132 @default.
- W4353069342 cites W2125066141 @default.
- W4353069342 cites W2128811703 @default.
- W4353069342 cites W2136012853 @default.
- W4353069342 cites W2138814983 @default.
- W4353069342 cites W2141198202 @default.
- W4353069342 cites W2143692153 @default.
- W4353069342 cites W2152848856 @default.
- W4353069342 cites W2154529549 @default.
- W4353069342 cites W2156346381 @default.
- W4353069342 cites W2160615504 @default.
- W4353069342 cites W2224438538 @default.
- W4353069342 cites W2313736691 @default.
- W4353069342 cites W2325927901 @default.
- W4353069342 cites W2339008264 @default.
- W4353069342 cites W2410758126 @default.
- W4353069342 cites W2416752091 @default.
- W4353069342 cites W2527118361 @default.
- W4353069342 cites W2567908819 @default.
- W4353069342 cites W2575726816 @default.
- W4353069342 cites W2597137467 @default.
- W4353069342 cites W2598229019 @default.
- W4353069342 cites W2611427019 @default.
- W4353069342 cites W2746047719 @default.
- W4353069342 cites W2759752974 @default.
- W4353069342 cites W2806184970 @default.
- W4353069342 cites W2912559469 @default.
- W4353069342 cites W2921827250 @default.
- W4353069342 cites W2945398440 @default.
- W4353069342 cites W2955861254 @default.
- W4353069342 cites W2963990900 @default.
- W4353069342 cites W2981763752 @default.
- W4353069342 cites W3006063293 @default.
- W4353069342 cites W3066936598 @default.
- W4353069342 cites W3087677212 @default.
- W4353069342 cites W3111318555 @default.
- W4353069342 cites W3130835958 @default.
- W4353069342 cites W3152059946 @default.