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• W4353070710 abstract "The study aimed to explore the association of serum 25(OH)D3 and hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients and to determine whether the effect of vitamin D (VD) is mediated by activation of the peroxisome proliferator-activated receptor α (PPARα) pathway.The study contained a case-control study, in vivo and in vitro experiments. A case-control study was conducted to compare serum parameters between NAFLD patients and controls and to evaluate the association of 25(OH)D3 and NAFLD. In vivo study, male Wistar rats were randomly divided into control and model groups, fed a standard chow diet and a high-fat diet (HFD), respectively, for 7 weeks to generate an NAFLD model. Then, the rats were treated with VD and a PPARα antagonist (MK886) for 7 weeks. Tissue and serum were collected and assessed by biochemical assays, morphological analysis, histological analysis, and western blot analysis. In vitro, HepG2 cells were incubated with oleic acid (OA) to induce steatosis, which was evaluated by staining. HepG2 cells were pretreated with MK886 followed by calcitriol treatment, and differences in lipid metabolism-related proteins were detected by western blot.NAFLD patients were characterized by impaired liver function, dyslipidemia, and insulin resistance. Serum 25(OH)D3 was negatively associated with alanine aminotransferase (ALT) in NAFLD. VD deficiency was a risk factor for patients with no advanced fibrosis. Adequate VD status (25(OH)D3 >20 ng/mL) had a protective effect in patients after adjustment for confounding variables. NAFLD rats showed hyperlipidemia with severe hepatic steatosis, systematic inflammation, and lower serum 25(OH)D3. VD treatment ameliorated hepatic steatosis both in NAFLD rats and OA-induced HepG2 cells. Further, MK886 inhibited the anti-steatosis effect of VD.The study revealed that an adequate VD level may act as a protective factor in NAFLD and that VD may alleviate hepatic steatosis via the PPARα signaling pathway." @default.
• W4353070710 created "2023-03-23" @default.
• W4353070710 creator A5020200362 @default.
• W4353070710 creator A5026993561 @default.
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• W4353070710 creator A5090452340 @default.
• W4353070710 date "2023-03-22" @default.
• W4353070710 modified "2023-10-05" @default.
• W4353070710 title "Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation" @default.
• W4353070710 cites W1973617421 @default.
• W4353070710 cites W2057521072 @default.
• W4353070710 cites W2072362233 @default.
• W4353070710 cites W2085298586 @default.
• W4353070710 cites W2103563428 @default.
• W4353070710 cites W2179972854 @default.
• W4353070710 cites W2287810838 @default.
• W4353070710 cites W2545876555 @default.
• W4353070710 cites W2564650850 @default.
• W4353070710 cites W2583180104 @default.
• W4353070710 cites W2589271384 @default.
• W4353070710 cites W2776961826 @default.
• W4353070710 cites W2802363002 @default.
• W4353070710 cites W2803136531 @default.
• W4353070710 cites W2803897617 @default.
• W4353070710 cites W2903274106 @default.
• W4353070710 cites W2905282109 @default.
• W4353070710 cites W2907281453 @default.
• W4353070710 cites W2950722971 @default.
• W4353070710 cites W2972688950 @default.
• W4353070710 cites W2993791841 @default.
• W4353070710 cites W2997840987 @default.
• W4353070710 cites W2999489695 @default.
• W4353070710 cites W3002975581 @default.
• W4353070710 cites W3004279476 @default.
• W4353070710 cites W3012883032 @default.
• W4353070710 cites W3082368737 @default.
• W4353070710 cites W3127004353 @default.
• W4353070710 cites W3129910083 @default.
• W4353070710 cites W3151275211 @default.
• W4353070710 cites W3157395536 @default.
• W4353070710 cites W3157466953 @default.
• W4353070710 cites W3159463019 @default.
• W4353070710 cites W3163003140 @default.
• W4353070710 cites W3163158453 @default.
• W4353070710 cites W3165658712 @default.
• W4353070710 cites W3177293413 @default.
• W4353070710 cites W3181209874 @default.
• W4353070710 cites W3184623510 @default.
• W4353070710 cites W3184787320 @default.
• W4353070710 cites W3195816718 @default.
• W4353070710 cites W3211962528 @default.
• W4353070710 cites W4205183415 @default.
• W4353070710 cites W4205477539 @default.
• W4353070710 cites W4206293601 @default.
• W4353070710 cites W4210393615 @default.
• W4353070710 cites W4210660034 @default.
• W4353070710 cites W4210666233 @default.
• W4353070710 cites W4210872222 @default.
• W4353070710 cites W4212966036 @default.
• W4353070710 cites W4220698518 @default.
• W4353070710 cites W4220724390 @default.
• W4353070710 cites W4220767804 @default.
• W4353070710 cites W4223907218 @default.
• W4353070710 cites W4224313007 @default.
• W4353070710 cites W4280533675 @default.
• W4353070710 cites W4280552835 @default.
• W4353070710 cites W4281692922 @default.
• W4353070710 cites W4282838589 @default.
• W4353070710 cites W4283024235 @default.
• W4353070710 cites W4283119287 @default.
• W4353070710 cites W4283217201 @default.
• W4353070710 cites W4283447252 @default.
• W4353070710 cites W4283748169 @default.
• W4353070710 cites W4285795956 @default.
• W4353070710 cites W4288040369 @default.
• W4353070710 cites W4288068479 @default.
• W4353070710 cites W4291777273 @default.
• W4353070710 cites W4293096820 @default.
• W4353070710 cites W4293287870 @default.
• W4353070710 cites W4295063387 @default.
• W4353070710 cites W4295222581 @default.
• W4353070710 cites W4295234410 @default.
• W4353070710 cites W4295908397 @default.
• W4353070710 cites W4297311805 @default.
• W4353070710 cites W4301185349 @default.
• W4353070710 cites W4306878778 @default.
• W4353070710 cites W4308188442 @default.
• W4353070710 cites W4308427790 @default.
• W4353070710 cites W4309411145 @default.
• W4353070710 cites W4309738947 @default.
• W4353070710 cites W4309742858 @default.
• W4353070710 cites W4309847966 @default.
• W4353070710 cites W4310039564 @default.
• W4353070710 cites W4310956247 @default.
• W4353070710 cites W4311582242 @default.
• W4353070710 cites W4312123565 @default.

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