Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353072693> ?p ?o ?g. }
- W4353072693 endingPage "1523" @default.
- W4353072693 startingPage "1523" @default.
- W4353072693 abstract "Maternal obesity is an intergenerational vicious cycle and one of the primary causes of cognitive deficits and high anxiety levels in offspring, which often manifest independently of sex. It is proven that curbing the intergenerational inheritance of obesity through early intervention during the gestation period has a positive outcome on the body composition, cognitive function, and anxiety level of the offspring. A recent discovery shows that the consumption of Elateriospermum tapos (E. tapos) seed extract modulates body mass and ameliorates stress hormones in obese dams, while a probiotic bacterial strain can cross the placenta and boost a child's memory. Thus, we speculate that probiotics are the best medium to integrate plant extract (E. tapos extract) to access the effect on the child's cognition. Thus, this study aimed to investigate the early intervention of E. tapos yoghurt in obese dams in the cognition and anxiety levels of male offspring. In this study, 40 female rats were fed with a high-fat diet (HFD) to induce obesity before pregnancy, while another 8 rats were fed with standard rat pellets for 16 weeks. Upon successful copulation, treatment was initiated for the obese dams up to the postnatal day (PND) 21. The groups included normal chow and saline (NS), HFD and saline (HS), HFD and yoghurt (HY), HFD and 5 mg/kg E. tapos yoghurt (HYT5), HFD and 50 mg/kg E. tapos yoghurt (HYT50), and HFD and 500 mg/kg E. tapos yoghurt (HYT500). All rats were euthanised on PND 21, and the body mass index (BMI), Lee index, and waist circumference were measured for the male offspring. Hippocampal-dependent memory tests and open field tests were conducted to access for cognition and anxiety status. Fasting blood glucose (FBG), total fat (%), insulin, leptin, lipid profile, and antioxidant parameter on serum and hypothalamus (FRAP and GSH) were accessed on PND 21. The result shows male offspring of 50 mg/kg-supplemented obese dams have comparable total fat (%), lipid profile, insulin level, FBG level, plasma insulin level, recognition index, low anxiety level, and improved hypothalamic FRAP and GSH levels to the normal group. In conclusion, this study highlights that the effect of early intervention of our novel formulation of E. tapos yoghurt in obese dams alleviates cognitive deficits and anxiety in male offspring by modulating metabolic profiles at the dose of 50 mg/kg." @default.
- W4353072693 created "2023-03-23" @default.
- W4353072693 creator A5009123079 @default.
- W4353072693 creator A5034481569 @default.
- W4353072693 creator A5043403475 @default.
- W4353072693 creator A5065626826 @default.
- W4353072693 creator A5066591544 @default.
- W4353072693 creator A5083591620 @default.
- W4353072693 date "2023-03-21" @default.
- W4353072693 modified "2023-10-04" @default.
- W4353072693 title "Early Intervention of Elateriospermum tapos Yoghurt in Obese Dams Mitigates Intergenerational Cognitive Deficits and Thigmotactic Behaviour in Male Offspring via the Modulation of Metabolic Profile" @default.
- W4353072693 cites W1501270773 @default.
- W4353072693 cites W1523092920 @default.
- W4353072693 cites W1728276264 @default.
- W4353072693 cites W1865891749 @default.
- W4353072693 cites W192756024 @default.
- W4353072693 cites W1982761508 @default.
- W4353072693 cites W1996741224 @default.
- W4353072693 cites W1997312032 @default.
- W4353072693 cites W1998622776 @default.
- W4353072693 cites W2006716849 @default.
- W4353072693 cites W2009741614 @default.
- W4353072693 cites W2032625786 @default.
- W4353072693 cites W2033898136 @default.
- W4353072693 cites W2039407707 @default.
- W4353072693 cites W2056270090 @default.
- W4353072693 cites W2059717138 @default.
- W4353072693 cites W2087283572 @default.
- W4353072693 cites W2108576543 @default.
- W4353072693 cites W2119702013 @default.
- W4353072693 cites W2124135994 @default.
- W4353072693 cites W2133186967 @default.
- W4353072693 cites W2146804112 @default.
- W4353072693 cites W2296915958 @default.
- W4353072693 cites W2525747862 @default.
- W4353072693 cites W2608151955 @default.
- W4353072693 cites W2738612376 @default.
- W4353072693 cites W2739668830 @default.
- W4353072693 cites W2761488119 @default.
- W4353072693 cites W2768976479 @default.
- W4353072693 cites W2770549430 @default.
- W4353072693 cites W2790652465 @default.
- W4353072693 cites W2808686421 @default.
- W4353072693 cites W2890570900 @default.
- W4353072693 cites W2898467211 @default.
- W4353072693 cites W2947986377 @default.
- W4353072693 cites W2979421359 @default.
- W4353072693 cites W2987960305 @default.
- W4353072693 cites W3023613420 @default.
- W4353072693 cites W3027848330 @default.
- W4353072693 cites W3046159291 @default.
- W4353072693 cites W3072308348 @default.
- W4353072693 cites W3094428135 @default.
- W4353072693 cites W3095017785 @default.
- W4353072693 cites W3095684596 @default.
- W4353072693 cites W3110667866 @default.
- W4353072693 cites W3119535834 @default.
- W4353072693 cites W3120293320 @default.
- W4353072693 cites W3126346287 @default.
- W4353072693 cites W3128176007 @default.
- W4353072693 cites W3128515044 @default.
- W4353072693 cites W3132740864 @default.
- W4353072693 cites W3182412319 @default.
- W4353072693 cites W3203708713 @default.
- W4353072693 cites W3203715214 @default.
- W4353072693 cites W4200076291 @default.
- W4353072693 cites W4200531309 @default.
- W4353072693 cites W4200598318 @default.
- W4353072693 cites W4206120359 @default.
- W4353072693 cites W4210453011 @default.
- W4353072693 cites W4220869791 @default.
- W4353072693 cites W4224212196 @default.
- W4353072693 cites W4225706939 @default.
- W4353072693 cites W4280566486 @default.
- W4353072693 cites W4283371854 @default.
- W4353072693 cites W4283650345 @default.
- W4353072693 cites W4286471512 @default.
- W4353072693 cites W4319878230 @default.
- W4353072693 cites W4323044197 @default.
- W4353072693 cites W2800288099 @default.
- W4353072693 doi "https://doi.org/10.3390/nu15061523" @default.
- W4353072693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36986254" @default.
- W4353072693 hasPublicationYear "2023" @default.
- W4353072693 type Work @default.
- W4353072693 citedByCount "3" @default.
- W4353072693 countsByYear W43530726932023 @default.
- W4353072693 crossrefType "journal-article" @default.
- W4353072693 hasAuthorship W4353072693A5009123079 @default.
- W4353072693 hasAuthorship W4353072693A5034481569 @default.
- W4353072693 hasAuthorship W4353072693A5043403475 @default.
- W4353072693 hasAuthorship W4353072693A5065626826 @default.
- W4353072693 hasAuthorship W4353072693A5066591544 @default.
- W4353072693 hasAuthorship W4353072693A5083591620 @default.
- W4353072693 hasBestOaLocation W43530726931 @default.
- W4353072693 hasConcept C112672928 @default.
- W4353072693 hasConcept C118552586 @default.
- W4353072693 hasConcept C126322002 @default.
- W4353072693 hasConcept C134018914 @default.