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- W4353082011 abstract "Objectives Antimicrobial resistance is global pandemic that poses a major threat to vision health as ocular pathogens, especially staphylococcal species, are becoming increasingly resistant to first-line therapies. Here we evaluated the antimicrobial activity of a new class of synthetic retinoids in comparison to currently used antibiotics against clinically relevant ocular staphylococcal isolates. Methods Antimicrobial susceptibility testing was performed by broth microdilution for 3 novel synthetic retinoids (CD1530, CD437, and a CD437 analogue) and 7 comparator antibiotics, against a collection of 216 clinical isolates. Results CD437 MIC 50 and MIC 90 were 2 µg/mL for Staphylococcus aureus , and 1 µg/mL and 2 µg/mL respectively, for coagulase-negative staphylococci (CoNS). CD1530 (MIC 50 = 2 µg/mL for all species) also displayed good activity with an in vitro potency slightly lower (2-fold) for S. aureus (MIC 90 = 4 µg/mL) when compared to CD437. A CD437 analogue also demonstrated good in vitro activity (MIC 50 = 2 µg/mL for all species) and potency (MIC 90 = 2 µg/mL for MRSA and 4 µg/mL for MSSA and CoNS). In vitro potencies were similar or higher than that of comparator agents, and were not impacted by multidrug resistance phenotypes. Conclusion Our results demonstrate that synthetic retinoids display potent in vitro activity against ocular staphylococcal species, including multidrug-resistant isolates." @default.
- W4353082011 created "2023-03-23" @default.
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- W4353082011 date "2023-03-22" @default.
- W4353082011 modified "2023-10-04" @default.
- W4353082011 title "Antimicrobial activity of a new class of synthetic retinoid antibiotics and comparator agents against ocular staphylococci" @default.
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- W4353082011 doi "https://doi.org/10.3389/frabi.2023.1101450" @default.
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