Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353082013> ?p ?o ?g. }
- W4353082013 abstract "Neurofibrillary tangles (NFT) is one of the hallmarks of Alzheimer's disease (AD). Recent research suggests that pretangle tau, the soluble precursor of NFT, is an initiator for AD pathogenesis, thus targeting pretangle tau pathology may be a promising early intervention focus. The bidirectional communications between the gut and the brain play a crucial role in health. The compromised gut-brain axis is involved in various neurodegenerative diseases including AD. However, most research on the relationship between gut microbiome and AD have focused on amyloid-β. In this mini review, we propose to target preclinical pretangle tau stages with gut microbiota interventions such as probiotic supplementation. We discuss the importance of targeting pretangle tau that starts decades before the onset of clinical symptoms, and potential intervention focusing on probiotic regulation of tau hyperphosphorylation. A particular focus is on GSK-3β, a protein kinase that is at the interface between tau phosphorylation, AD and diabetes mellitus." @default.
- W4353082013 created "2023-03-23" @default.
- W4353082013 creator A5004290819 @default.
- W4353082013 creator A5022168690 @default.
- W4353082013 date "2023-03-22" @default.
- W4353082013 modified "2023-09-26" @default.
- W4353082013 title "Probiotic supplement as a promising strategy in early tau pathology prevention: Focusing on GSK-3β?" @default.
- W4353082013 cites W1483825698 @default.
- W4353082013 cites W1513401887 @default.
- W4353082013 cites W1522284801 @default.
- W4353082013 cites W1577837690 @default.
- W4353082013 cites W1601066682 @default.
- W4353082013 cites W1893993890 @default.
- W4353082013 cites W1913092771 @default.
- W4353082013 cites W1960383488 @default.
- W4353082013 cites W1960647274 @default.
- W4353082013 cites W1963933632 @default.
- W4353082013 cites W1966668014 @default.
- W4353082013 cites W1974729491 @default.
- W4353082013 cites W1976010325 @default.
- W4353082013 cites W1977560589 @default.
- W4353082013 cites W1984652813 @default.
- W4353082013 cites W1992491411 @default.
- W4353082013 cites W1993023011 @default.
- W4353082013 cites W2015001118 @default.
- W4353082013 cites W2016575029 @default.
- W4353082013 cites W2018983416 @default.
- W4353082013 cites W2021943859 @default.
- W4353082013 cites W2029462234 @default.
- W4353082013 cites W2031864556 @default.
- W4353082013 cites W2033305016 @default.
- W4353082013 cites W2035421462 @default.
- W4353082013 cites W2039550162 @default.
- W4353082013 cites W2045409916 @default.
- W4353082013 cites W2052742260 @default.
- W4353082013 cites W2053936304 @default.
- W4353082013 cites W2057249855 @default.
- W4353082013 cites W2058581619 @default.
- W4353082013 cites W2075725519 @default.
- W4353082013 cites W2075760053 @default.
- W4353082013 cites W2080595517 @default.
- W4353082013 cites W2082429191 @default.
- W4353082013 cites W2083725282 @default.
- W4353082013 cites W2084453905 @default.
- W4353082013 cites W2088349113 @default.
- W4353082013 cites W2112136536 @default.
- W4353082013 cites W2114729479 @default.
- W4353082013 cites W2115309909 @default.
- W4353082013 cites W2117283767 @default.
- W4353082013 cites W2125985978 @default.
- W4353082013 cites W2131760568 @default.
- W4353082013 cites W2135148756 @default.
- W4353082013 cites W2135309154 @default.
- W4353082013 cites W2152446053 @default.
- W4353082013 cites W2156297351 @default.
- W4353082013 cites W2164493941 @default.
- W4353082013 cites W2182063174 @default.
- W4353082013 cites W2418793943 @default.
- W4353082013 cites W2466890096 @default.
- W4353082013 cites W2501254514 @default.
- W4353082013 cites W2513816257 @default.
- W4353082013 cites W2554957493 @default.
- W4353082013 cites W2556090133 @default.
- W4353082013 cites W2605571752 @default.
- W4353082013 cites W2745657465 @default.
- W4353082013 cites W2751377372 @default.
- W4353082013 cites W2753475839 @default.
- W4353082013 cites W2761210275 @default.
- W4353082013 cites W2761422368 @default.
- W4353082013 cites W2762190287 @default.
- W4353082013 cites W2767503609 @default.
- W4353082013 cites W2769744721 @default.
- W4353082013 cites W2770586248 @default.
- W4353082013 cites W2772763207 @default.
- W4353082013 cites W2792526694 @default.
- W4353082013 cites W2802853266 @default.
- W4353082013 cites W2803442844 @default.
- W4353082013 cites W2806841541 @default.
- W4353082013 cites W2808028315 @default.
- W4353082013 cites W2811371297 @default.
- W4353082013 cites W2877688611 @default.
- W4353082013 cites W2888303999 @default.
- W4353082013 cites W2890637781 @default.
- W4353082013 cites W2907547898 @default.
- W4353082013 cites W2909041556 @default.
- W4353082013 cites W2946976245 @default.
- W4353082013 cites W2954842119 @default.
- W4353082013 cites W2955273706 @default.
- W4353082013 cites W2967026120 @default.
- W4353082013 cites W2969092691 @default.
- W4353082013 cites W2971877727 @default.
- W4353082013 cites W2987960305 @default.
- W4353082013 cites W3003605792 @default.
- W4353082013 cites W3014373268 @default.
- W4353082013 cites W3016525705 @default.
- W4353082013 cites W3016972382 @default.
- W4353082013 cites W3027163655 @default.
- W4353082013 cites W3043167826 @default.
- W4353082013 cites W3087420719 @default.
- W4353082013 cites W3130034313 @default.