Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353084920> ?p ?o ?g. }
- W4353084920 abstract "The maturation of human stem cell-derived cardiomyocytes (hSC-CMs) has been a major challenge to further expand the scope of their application. Over the past years, several strategies have been proven to facilitate the structural and functional maturation of hSC-CMs, which include but are not limited to engineering the geometry or stiffness of substrates, providing favorable extracellular matrices, applying mechanical stretch, fluidic or electrical stimulation, co-culturing with niche cells, regulating biochemical cues such as hormones and transcription factors, engineering and redirecting metabolic patterns, developing 3D cardiac constructs such as cardiac organoid or engineered heart tissue, or culturing under in vivo implantation. In this review, we summarize these maturation strategies, especially the recent advancements, and discussed their advantages as well as the pressing problems that need to be addressed in future studies." @default.
- W4353084920 created "2023-03-23" @default.
- W4353084920 creator A5010366011 @default.
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- W4353084920 creator A5073531557 @default.
- W4353084920 creator A5077068949 @default.
- W4353084920 creator A5090519794 @default.
- W4353084920 date "2023-03-22" @default.
- W4353084920 modified "2023-10-03" @default.
- W4353084920 title "Engineering the maturation of stem cell-derived cardiomyocytes" @default.
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