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- W4353088292 abstract "Metabolic reprogramming is recognized as an essential hallmark in carcinogenesis. By investigating the cancer-specific alterations in metabolism, several common cancer phenotypes, such as accumulated somatic mutations due to gene instability, irregulated nutrient consumption, uncontrolled growth and proliferation, and aberrational mitochondrial activities, becomes the interest of study. In this article, the overall profile of cancer metabolic activities including glucose and glutamine metabolism, macromolecules synthesis, aerobic glycolysis, pentose phosphate pathways, and mitochondrial activity, as well as two important signaling pathways (PI3K/AKT/mTOR and p53) regarding cancer metabolism are discussed. During cancer progression, the proto-oncogenes are amplified, and the tumor suppressor genes are repressed due to gene instability when cancer over-proliferated. The epigenetic changes affecting cellular signaling pathways and then triggering alterations in biosynthesis and bioenergetics to support cancer growth and proliferation with sufficient building blocks and energy. The article aims to give an overview of those cancer-associated metabolisms and show a profile of cancer-related metabolites and mutated enzymes. It also highlights the interconnections between metabolic activities, the interactions between signaling pathways and cancerous metabolism, and oncometabolites and aberrational enzymes that could potentially promote carcinogenesis; hence, become therapeutic targets for treatments." @default.
- W4353088292 created "2023-03-23" @default.
- W4353088292 creator A5050914571 @default.
- W4353088292 date "2023-03-21" @default.
- W4353088292 modified "2023-10-04" @default.
- W4353088292 title "Nutrient Metabolisms in Cancer and Related Signaling Pathways" @default.
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- W4353088292 doi "https://doi.org/10.54097/hset.v36i.6238" @default.
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