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- W4353090634 endingPage "5992" @default.
- W4353090634 startingPage "5992" @default.
- W4353090634 abstract "Neuroinflammation and brain lipid imbalances are observed in Alzheimer’s disease (AD). Tumor necrosis factor-α (TNFα) and the liver X receptor (LXR) signaling pathways are involved in both processes. However, limited information is currently available regarding their relationships in human brain pericytes (HBP) of the neurovascular unit. In cultivated HBP, TNFα activates the LXR pathway and increases the expression of one of its target genes, the transporter ATP-binding cassette family A member 1 (ABCA1), while ABCG1 is not expressed. Apolipoprotein E (APOE) synthesis and release are diminished. The cholesterol efflux is promoted, but is not inhibited, when ABCA1 or LXR are blocked. Moreover, as for TNFα, direct LXR activation by the agonist (T0901317) increases ABCA1 expression and the associated cholesterol efflux. However, this process is abolished when LXR/ABCA1 are both inhibited. Neither the other ABC transporters nor the SR-BI are involved in this TNFα-mediated lipid efflux regulation. We also report that inflammation increases ABCB1 expression and function. In conclusion, our data suggest that inflammation increases HBP protection against xenobiotics and triggers an LXR/ABCA1 independent cholesterol release. Understanding the molecular mechanisms regulating this efflux at the level of the neurovascular unit remains fundamental to the characterization of links between neuroinflammation, cholesterol and HBP function in neurodegenerative disorders." @default.
- W4353090634 created "2023-03-23" @default.
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- W4353090634 date "2023-03-22" @default.
- W4353090634 modified "2023-10-13" @default.
- W4353090634 title "TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1" @default.
- W4353090634 cites W103569516 @default.
- W4353090634 cites W1512719559 @default.
- W4353090634 cites W1717020381 @default.
- W4353090634 cites W1733658784 @default.
- W4353090634 cites W1931867099 @default.
- W4353090634 cites W1974761264 @default.
- W4353090634 cites W1991166529 @default.
- W4353090634 cites W2001658740 @default.
- W4353090634 cites W2006161539 @default.
- W4353090634 cites W2007960303 @default.
- W4353090634 cites W2013348589 @default.
- W4353090634 cites W2013375919 @default.
- W4353090634 cites W2014120652 @default.
- W4353090634 cites W2021181758 @default.
- W4353090634 cites W2027703774 @default.
- W4353090634 cites W2051881287 @default.
- W4353090634 cites W2056856515 @default.
- W4353090634 cites W2058571175 @default.
- W4353090634 cites W2061941384 @default.
- W4353090634 cites W2072874329 @default.
- W4353090634 cites W2075175167 @default.
- W4353090634 cites W2077216169 @default.
- W4353090634 cites W2082864993 @default.
- W4353090634 cites W2085374176 @default.
- W4353090634 cites W2107290681 @default.
- W4353090634 cites W2107325549 @default.
- W4353090634 cites W2111482014 @default.
- W4353090634 cites W2113675037 @default.
- W4353090634 cites W2114311313 @default.
- W4353090634 cites W2124928762 @default.
- W4353090634 cites W2128094952 @default.
- W4353090634 cites W2145210308 @default.
- W4353090634 cites W2147613942 @default.
- W4353090634 cites W2149217753 @default.
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- W4353090634 cites W2160591905 @default.
- W4353090634 cites W2165557965 @default.
- W4353090634 cites W2165895874 @default.
- W4353090634 cites W2166739849 @default.
- W4353090634 cites W2171889873 @default.
- W4353090634 cites W2280695772 @default.
- W4353090634 cites W2284826199 @default.
- W4353090634 cites W2336518991 @default.
- W4353090634 cites W2505322925 @default.
- W4353090634 cites W2587547716 @default.
- W4353090634 cites W2803391641 @default.
- W4353090634 cites W2884687278 @default.
- W4353090634 cites W2942418333 @default.
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- W4353090634 cites W3084341481 @default.
- W4353090634 cites W3092360522 @default.
- W4353090634 cites W3135121064 @default.
- W4353090634 cites W3136719099 @default.
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- W4353090634 doi "https://doi.org/10.3390/ijms24065992" @default.
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