FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353094039> ?p ?o ?g. }

• W4353094039 endingPage "120038" @default.
• W4353094039 startingPage "120038" @default.
• W4353094039 abstract "Cerebrovascular reactivity (CVR), defined as the cerebral blood flow response to a vasoactive stimulus, is an imaging biomarker with demonstrated utility in a range of diseases and in typical development and aging processes. A robust and widely implemented method to map CVR involves using a breath-hold task during a BOLD fMRI scan. Recording end-tidal CO2 (PETCO2) changes during the breath-hold task is recommended to be used as a reference signal for modeling CVR amplitude in standard units (%BOLD/mmHg) and CVR delay in seconds. However, obtaining reliable PETCO2 recordings requires equipment and task compliance that may not be achievable in all settings. To address this challenge, we investigated two alternative reference signals to map CVR amplitude and delay in a lagged general linear model (lagged-GLM) framework: respiration volume per time (RVT) and average gray matter BOLD response (GM-BOLD). In 8 healthy adults with multiple scan sessions, we compare spatial agreement of CVR maps from RVT and GM-BOLD to those generated with PETCO2. We define a threshold to determine whether a PETCO2 recording has “sufficient” quality for CVR mapping and perform these comparisons in 16 datasets with sufficient PETCO2 and 6 datasets with insufficient PETCO2. When PETCO2 quality is sufficient, both RVT and GM-BOLD produce CVR amplitude maps that are nearly identical to those from PETCO2 (after accounting for differences in scale), with the caveat they are not in standard units to facilitate between-group comparisons. CVR delays are comparable to PETCO2 with an RVT regressor but may be underestimated with the average GM-BOLD regressor. Importantly, when PETCO2 quality is insufficient, RVT and GM-BOLD CVR recover reasonable CVR amplitude and delay maps, provided the participant attempted the breath-hold task. Therefore, our framework offers a solution for achieving high quality CVR maps in both retrospective and prospective studies where sufficient PETCO2 recordings are not available and especially in populations where obtaining reliable measurements is a known challenge (e.g., children). Our results have the potential to improve the accessibility of CVR mapping and to increase the prevalence of this promising metric of vascular health." @default.
• W4353094039 created "2023-03-23" @default.
• W4353094039 creator A5022744697 @default.
• W4353094039 creator A5060918448 @default.
• W4353094039 creator A5066453025 @default.
• W4353094039 creator A5074299216 @default.
• W4353094039 creator A5075135194 @default.
• W4353094039 creator A5076557896 @default.
• W4353094039 date "2023-05-01" @default.
• W4353094039 modified "2023-10-14" @default.
• W4353094039 title "Comparing end-tidal CO2, respiration volume per time (RVT), and average gray matter signal for mapping cerebrovascular reactivity amplitude and delay with breath-hold task BOLD fMRI" @default.
• W4353094039 cites W1497608667 @default.
• W4353094039 cites W1529887509 @default.
• W4353094039 cites W1591163814 @default.
• W4353094039 cites W1605722113 @default.
• W4353094039 cites W1716994822 @default.
• W4353094039 cites W1779672325 @default.
• W4353094039 cites W1828927092 @default.
• W4353094039 cites W1894207460 @default.
• W4353094039 cites W1919395887 @default.
• W4353094039 cites W1971456886 @default.
• W4353094039 cites W1972690852 @default.
• W4353094039 cites W1972939851 @default.
• W4353094039 cites W1977083231 @default.
• W4353094039 cites W1980037751 @default.
• W4353094039 cites W1984453610 @default.
• W4353094039 cites W1986387796 @default.
• W4353094039 cites W2005111082 @default.
• W4353094039 cites W2009621566 @default.
• W4353094039 cites W2012129172 @default.
• W4353094039 cites W2018175199 @default.
• W4353094039 cites W2020708496 @default.
• W4353094039 cites W2021541933 @default.
• W4353094039 cites W2028890762 @default.
• W4353094039 cites W2029676341 @default.
• W4353094039 cites W2031335742 @default.
• W4353094039 cites W2046104092 @default.
• W4353094039 cites W2048034803 @default.
• W4353094039 cites W2049325056 @default.
• W4353094039 cites W2050096761 @default.
• W4353094039 cites W2051426766 @default.
• W4353094039 cites W2051998615 @default.
• W4353094039 cites W2052644075 @default.
• W4353094039 cites W2058253334 @default.
• W4353094039 cites W2058709849 @default.
• W4353094039 cites W2060467175 @default.
• W4353094039 cites W2066470779 @default.
• W4353094039 cites W2067417098 @default.
• W4353094039 cites W2068067169 @default.
• W4353094039 cites W2073886740 @default.
• W4353094039 cites W2074941631 @default.
• W4353094039 cites W2079776123 @default.
• W4353094039 cites W2096473858 @default.
• W4353094039 cites W2097985509 @default.
• W4353094039 cites W2100802962 @default.
• W4353094039 cites W2101523846 @default.
• W4353094039 cites W2103771964 @default.
• W4353094039 cites W2106154674 @default.
• W4353094039 cites W2112638240 @default.
• W4353094039 cites W2117140276 @default.
• W4353094039 cites W2128070813 @default.
• W4353094039 cites W2129291315 @default.
• W4353094039 cites W2136543288 @default.
• W4353094039 cites W2145403933 @default.
• W4353094039 cites W2148726987 @default.
• W4353094039 cites W2154152782 @default.
• W4353094039 cites W2162391242 @default.
• W4353094039 cites W2167817871 @default.
• W4353094039 cites W2167993960 @default.
• W4353094039 cites W2170797424 @default.
• W4353094039 cites W2262831799 @default.
• W4353094039 cites W2279348102 @default.
• W4353094039 cites W2284869975 @default.
• W4353094039 cites W2299068511 @default.
• W4353094039 cites W2305359967 @default.
• W4353094039 cites W2361738751 @default.
• W4353094039 cites W2409094316 @default.
• W4353094039 cites W2465207860 @default.
• W4353094039 cites W2470078412 @default.
• W4353094039 cites W2512138671 @default.
• W4353094039 cites W2519885061 @default.
• W4353094039 cites W2526501380 @default.
• W4353094039 cites W2553831596 @default.
• W4353094039 cites W2559595761 @default.
• W4353094039 cites W2560079766 @default.
• W4353094039 cites W2604599100 @default.
• W4353094039 cites W2610498449 @default.
• W4353094039 cites W2759657329 @default.
• W4353094039 cites W2763977064 @default.
• W4353094039 cites W2764295685 @default.
• W4353094039 cites W2793407983 @default.
• W4353094039 cites W2821792225 @default.
• W4353094039 cites W2888471296 @default.
• W4353094039 cites W2905534313 @default.
• W4353094039 cites W2905981548 @default.
• W4353094039 cites W2912323169 @default.
• W4353094039 cites W2922858463 @default.
• W4353094039 cites W2951103577 @default.

• next