FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4353101202> ?p ?o ?g. }

• W4353101202 endingPage "586" @default.
• W4353101202 startingPage "574" @default.
• W4353101202 abstract "Ovarian cancer is the second leading cause of death in women with gynecological malignancy in China. Circular RNAs are a class of noncoding regulatory RNAs reported to be involved in cancer development and progression. Previous studies, including our own, have indicated that hsa_circ_0007444 is downregulated in ovarian cancer tissues. This study aims to elucidate the function and mechanism of hsa_circ_0007444 in ovarian cancer progression. The expression of hsa_circ_0007444 is determined by quantitative real-time PCR (qRT-PCR). Cell proliferation, invasion, migration and apoptosis are examined by cell counting-kit 8 (CCK-8), transwell and flow cytometry assays. Tumor growth and metastasis are assessed in vivo using Balb/c nude mouse xenograft model and tail vein injection model. And the mechanism of action of hsa_circ_0007444 is analysed by RNA-binding protein immunoprecipitation (RIP), luciferase reporter and rescue assays. hsa_circ_0007444 is downregulated in ovarian cancer tissues and cell lines compared with that in normal ovarian tissues and normal epithelial cell line. Gain- and loss-of-function results indicate that hsa_circ_0007444 inhibits cell proliferation, invasion, migration and increases cell apoptosis of ovarian cancer cells in vitro, and inhibits tumor growth and lung metastasis in vivo. Mechanistically, hsa_circ_0007444 can interact with AGO2 and sponge miR-23a-3p, thereby upregulating DICER1 expression, which is an important tumor suppressor in ovarian cancer. And miR-23a-3p mimics can rescue the inhibitory effect of hsa_circ_0007444 on ovarian cancer cell proliferation, invasion and migration. Therefore, hsa_circ_0007444 can inhibit ovarian cancer progression through the hsa_circ_0007444/miR-23a-3p/DICER1 axis." @default.
• W4353101202 created "2023-03-23" @default.
• W4353101202 creator A5003221894 @default.
• W4353101202 creator A5005082513 @default.
• W4353101202 creator A5023307885 @default.
• W4353101202 creator A5038160156 @default.
• W4353101202 creator A5039315799 @default.
• W4353101202 creator A5047926973 @default.
• W4353101202 creator A5053204257 @default.
• W4353101202 creator A5056378144 @default.
• W4353101202 date "2023-04-01" @default.
• W4353101202 modified "2023-09-26" @default.
• W4353101202 title "Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis" @default.
• W4353101202 cites W1541974580 @default.
• W4353101202 cites W1866220599 @default.
• W4353101202 cites W2006247279 @default.
• W4353101202 cites W2024248021 @default.
• W4353101202 cites W2046387002 @default.
• W4353101202 cites W2052101095 @default.
• W4353101202 cites W2055493067 @default.
• W4353101202 cites W2094253263 @default.
• W4353101202 cites W2134719151 @default.
• W4353101202 cites W2147806662 @default.
• W4353101202 cites W2166646088 @default.
• W4353101202 cites W2204741763 @default.
• W4353101202 cites W2210577735 @default.
• W4353101202 cites W2220171776 @default.
• W4353101202 cites W2325596649 @default.
• W4353101202 cites W2341291028 @default.
• W4353101202 cites W2438866487 @default.
• W4353101202 cites W2513908100 @default.
• W4353101202 cites W2635073344 @default.
• W4353101202 cites W2763033314 @default.
• W4353101202 cites W2769047057 @default.
• W4353101202 cites W2790040397 @default.
• W4353101202 cites W2795546864 @default.
• W4353101202 cites W2797823977 @default.
• W4353101202 cites W2883062882 @default.
• W4353101202 cites W2888134420 @default.
• W4353101202 cites W2889139276 @default.
• W4353101202 cites W2890763709 @default.
• W4353101202 cites W2902877771 @default.
• W4353101202 cites W2913653068 @default.
• W4353101202 cites W2922474621 @default.
• W4353101202 cites W2940926945 @default.
• W4353101202 cites W2945357020 @default.
• W4353101202 cites W2947118253 @default.
• W4353101202 cites W2954161366 @default.
• W4353101202 cites W2966901040 @default.
• W4353101202 cites W2980855931 @default.
• W4353101202 cites W3004913097 @default.
• W4353101202 cites W3009541951 @default.
• W4353101202 cites W3011626103 @default.
• W4353101202 cites W3011796968 @default.
• W4353101202 cites W3031257405 @default.
• W4353101202 cites W3037589802 @default.
• W4353101202 cites W3046594653 @default.
• W4353101202 cites W3081368289 @default.
• W4353101202 cites W3095452002 @default.
• W4353101202 cites W3099719836 @default.
• W4353101202 cites W3120175463 @default.
• W4353101202 cites W4206841660 @default.
• W4353101202 cites W4214669832 @default.
• W4353101202 cites W2999783300 @default.
• W4353101202 doi "https://doi.org/10.3724/abbs.2023052" @default.
• W4353101202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37057923" @default.
• W4353101202 hasPublicationYear "2023" @default.
• W4353101202 type Work @default.
• W4353101202 citedByCount "1" @default.
• W4353101202 countsByYear W43531012022023 @default.
• W4353101202 crossrefType "journal-article" @default.
• W4353101202 hasAuthorship W4353101202A5003221894 @default.
• W4353101202 hasAuthorship W4353101202A5005082513 @default.
• W4353101202 hasAuthorship W4353101202A5023307885 @default.
• W4353101202 hasAuthorship W4353101202A5038160156 @default.
• W4353101202 hasAuthorship W4353101202A5039315799 @default.
• W4353101202 hasAuthorship W4353101202A5047926973 @default.
• W4353101202 hasAuthorship W4353101202A5053204257 @default.
• W4353101202 hasAuthorship W4353101202A5056378144 @default.
• W4353101202 hasBestOaLocation W43531012022 @default.
• W4353101202 hasConcept C121608353 @default.
• W4353101202 hasConcept C137738243 @default.
• W4353101202 hasConcept C150903083 @default.
• W4353101202 hasConcept C153911025 @default.
• W4353101202 hasConcept C185592680 @default.
• W4353101202 hasConcept C190283241 @default.
• W4353101202 hasConcept C207001950 @default.
• W4353101202 hasConcept C2779013556 @default.
• W4353101202 hasConcept C2779256057 @default.
• W4353101202 hasConcept C2780427987 @default.
• W4353101202 hasConcept C502942594 @default.
• W4353101202 hasConcept C54355233 @default.
• W4353101202 hasConcept C553184892 @default.
• W4353101202 hasConcept C55493867 @default.
• W4353101202 hasConcept C62112901 @default.
• W4353101202 hasConcept C81885089 @default.
• W4353101202 hasConcept C86803240 @default.
• W4353101202 hasConceptScore W4353101202C121608353 @default.

• next