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- W43545451 abstract "From the data stated above it appears that at least a combination of an activated oncogenic pathway and an inactivated tumor suppressor gene is needed in order for a skin cancer to arise: in SCC it is possibly an activated RTK/RAS pathway in combination with dysfunctional P53 tumor suppression, in BCC the Hedgehog pathway with possibly dysfunctional P53, and in CM again possibly an activated RTK/RAS in combination with inactivation of the INK4a locus. These combinations may be required, but not necessarily sufficient for the development of a tumor. Additional oncogenic events may be necessary." @default.
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- W43545451 date "2006-01-01" @default.
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- W43545451 title "UV Radiation, DNA Damage, Mutations and Skin Cancer" @default.
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- W43545451 doi "https://doi.org/10.1007/1-4020-3697-3_19" @default.
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