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- W4360596237 abstract "Peripheral blood is the most readily available resource for stroke patient prognosis, but there is a lack of methods to detect dynamic changes of neutrophils in peripheral blood that can be used in the clinic. Herein, we developed a procedure to characterize dynamic changes of neutrophils based on their electrical properties in rats after transient middle cerebral artery occlusion (MCAO). We characterized the specific membrane capacitance (C<sub>sm</sub>) and cytoplasmic resistance (σ<sub>cyto</sub>) of approximately 27,600 neutrophils from MCAO rats 24 h after ischemia/reperfusion. We found that the C<sub>sm</sub> and σ<sub>cyto</sub> of neutrophils in the MCAO group were significantly higher compared to the sham group. Furthermore, we observed a monotonically upward shift in neutrophil Csm in the MCAO group during the four 5-minute test cycles. Our findings suggest that the dynamic changes of cellular electrical properties could reflect neutrophil activity and serve as a prognostic indicator for ischemic stroke in the clinical setting." @default.
- W4360596237 created "2023-03-24" @default.
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- W4360596237 date "2023-01-01" @default.
- W4360596237 modified "2023-09-30" @default.
- W4360596237 title "Dynamic Detection of Specific Membrane Capacitance and Cytoplasmic Resistance of Neutrophils After Ischemic Stroke" @default.
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- W4360596237 doi "https://doi.org/10.14336/ad.2023.0127" @default.
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