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- W4360604407 abstract "Trauma leading to severe hemorrhage and shock on average kills patients within 3 to 6 hours after injury. With average prehospital transport times reaching 1-6 hours in low- to middle-income countries, stopping the bleeding and reversing hemorrhagic shock is vital. First-generation intravenous hemostats rely on traditional drug delivery platforms, such as self-assembling systems, fabricated nanoparticles, and soluble polymers due to their active targeting, biodistribution, and safety. We discuss some challenges translating these therapies to patients, as very few have successfully made it through preclinical evaluation in large-animals, and none have translated to the clinic. Finally, we discuss the physiology of hemorrhagic shock, highlight a new low volume resuscitant (LVR) PEG-20k, and end with considerations for the rational design of LVRs." @default.
- W4360604407 created "2023-03-24" @default.
- W4360604407 creator A5075083361 @default.
- W4360604407 creator A5080404671 @default.
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- W4360604407 date "2023-09-01" @default.
- W4360604407 modified "2023-10-14" @default.
- W4360604407 title "Engineered intravenous therapies for trauma" @default.
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- W4360604407 doi "https://doi.org/10.1016/j.cobme.2023.100456" @default.
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