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• W4360605617 abstract "You have accessJournal of UrologyCME1 Apr 2023PD45-02 THE IDEAL TIME INTERVAL BETWEEN REPEATED SHOCK WAVES LITHOTRIPSY SESSIONS FOR RENAL STONES: A RANDOMIZED CONTROLLED TRIAL Mohamed Fadallah, Ahmed R. EL-Nahas, Ahmed Abdelhalim, Wael I. Mortada, Abdelwahab Hashem, Hadeer A.M. Ibrahim, Khaled Z. Sheir, and Mahmoud R. EL-Kenawy Mohamed FadallahMohamed Fadallah More articles by this author , Ahmed R. EL-NahasAhmed R. EL-Nahas More articles by this author , Ahmed AbdelhalimAhmed Abdelhalim More articles by this author , Wael I. MortadaWael I. Mortada More articles by this author , Abdelwahab HashemAbdelwahab Hashem More articles by this author , Hadeer A.M. IbrahimHadeer A.M. Ibrahim More articles by this author , Khaled Z. SheirKhaled Z. Sheir More articles by this author , and Mahmoud R. EL-KenawyMahmoud R. EL-Kenawy More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003358.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: There is no consensus about the optimal time intervals between SWL repeated sessions. The study was conducted to assess the ideal interval between repeated SWL for renal stones. METHODS: The study protocol was approved by local ethical committee (ID: MD.20.05.327) and was registered to clinicaltrial.gov (NCT04575480). A randomized controlled trial was conducted between July 2020 and March 2022. Eligible patients with single renal stone<2 cm who required multiple SWL sessions were randomly assigned to one of three groups. Patients underwent 2nd session after (3,7 and 14 days) for groups (1,2 and 3) respectively. Tubular damage was assessed through estimation of changes in urinary execration of KIM-1, N-GAL and IL-18. While glomerular damage was assessed by the protein/ creatinine ratio and changes in renal DTPA isotope scan. Treatment success were assessed by NCCT after 3 months. RESULTS: The study included 166 patients. All patient's demographics were comparable between groups. There was significant elevation of protein /creatinine ratio and all tubular biomarkers post 1st and 2nd SWL when compared with pre-SWL values (p<0.0001 in all). All tubular damage biomarkers' values returned to pre-SWL at the planned day for the 3rd session in group 2 and 3 only (table 1). At 3 month follow up all urinary biomarkers and protein /creatine ratio were less than pre-SWL values in all groups. However, a significant decrease in ipsilateral renal split function was observed in group 1 only (p. value=0.005,0.887 and0.337 for group 1, 2 and 3 respectively . SWL treatment succeeded in 73.6% in group 1, 83.7% in group 2 and 81% in group 3. CONCLUSIONS: At least 7 days' interval is required between repeated session for treatment of renal stones to allow for complete recoverability of kidney glomerular and tubular functions. Source of Funding: we received funding from Urology and Nephrology Center - Mansoura University, Egypt © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1162 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mohamed Fadallah More articles by this author Ahmed R. EL-Nahas More articles by this author Ahmed Abdelhalim More articles by this author Wael I. Mortada More articles by this author Abdelwahab Hashem More articles by this author Hadeer A.M. Ibrahim More articles by this author Khaled Z. Sheir More articles by this author Mahmoud R. EL-Kenawy More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W4360605617 title "PD45-02 THE IDEAL TIME INTERVAL BETWEEN REPEATED SHOCK WAVES LITHOTRIPSY SESSIONS FOR RENAL STONES: A RANDOMIZED CONTROLLED TRIAL" @default.
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