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• W4360607621 abstract "You have accessJournal of UrologyCME1 Apr 2023PD10-12 HISTOPATHOLOGIC AND MRI CORRELATES OF ANTERIOR INDEX LESIONS IN PROSTATE CANCER: IMPLICATIONS FOR POST-SURGICAL ONCOLOGIC OUTCOMES Zoe Blake, Katie Merriman, Daniel Nemirovsky, Jacob Enders, Alexander Kenigsberg, Mason Belue, Enis Yilmaz, Tim Phelps, Neil Mendhiratta, Michael Rothberg, Daniel Nethala, Antoun Toubaji, Maria Merino, Bradford Wood, Sandeep Gurram, Stephanie Harmon, Peter Choyke, Baris Turkbey, and Peter Pinto Zoe BlakeZoe Blake More articles by this author , Katie MerrimanKatie Merriman More articles by this author , Daniel NemirovskyDaniel Nemirovsky More articles by this author , Jacob EndersJacob Enders More articles by this author , Alexander KenigsbergAlexander Kenigsberg More articles by this author , Mason BelueMason Belue More articles by this author , Enis YilmazEnis Yilmaz More articles by this author , Tim PhelpsTim Phelps More articles by this author , Neil MendhirattaNeil Mendhiratta More articles by this author , Michael RothbergMichael Rothberg More articles by this author , Daniel NethalaDaniel Nethala More articles by this author , Antoun ToubajiAntoun Toubaji More articles by this author , Maria MerinoMaria Merino More articles by this author , Bradford WoodBradford Wood More articles by this author , Sandeep GurramSandeep Gurram More articles by this author , Stephanie HarmonStephanie Harmon More articles by this author , Peter ChoykePeter Choyke More articles by this author , Baris TurkbeyBaris Turkbey More articles by this author , and Peter PintoPeter Pinto More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003250.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The influence of anatomic location of prostate cancer (PCa) on biochemical recurrence (BCR) after radical prostatectomy (RP) is an active area of research. Some evidence suggests that anterior lesions are more commonly associated with extra prostatic extension (EPE) due to lack of a distinct capsule in the anterior portion of the prostate, and are more prone to metastasize due to proximity of the Batson venous plexus. We sought to evaluate whether anterior index lesion location is associated with increased rates of EPE, BCR or lymph node invasion (LNI). METHODS: Clinical, imaging, and histopathological data were retrospectively analyzed for patients with PCa who underwent MRI prior to RP between 2008 and 2022. Anterior lesion location, as well as zonal anatomy, was determined by an expert genitourinary radiologist. Correlation with EPE, LNI, and BCR were analyzed using Wilcoxon rank sum and chi-squared tests. BCR-free survival (RFS) was analyzed using Kaplan-Meier (KM) survival curves. RESULTS: 662 RP patients were identified with median follow up of 19 months (IQR 11-35). Anterior lesions were not associated with an increased rate of MRI-detected EPE (p>0.995), pathology-confirmed EPE (p=0.119), LNI (p=0.059), or BCR (p=0.203) (Table 1). A sub-group analysis of anterior lesions by zonal anatomy revealed that transition zone (TZ) lesions were associated with higher rates of MRI-detected EPE than peripheral zone (PZ) lesions (25/144 [19.4%] vs 2/54 [3.7%], p=0.024) but not pathology-confirmed EPE (p=0.392), LNI (p=0.890), or BCR (p=0.525). Differences in RFS were not significant for anterior vs non-anterior lesions overall (p=0.27) or when zonally divided (p=0.11) (Figure 1). CONCLUSIONS: Anterior prostate lesions were not associated with increased rate of EPE, LNI, or difference in RFS, even when sub-stratifying lesions by zone. Thus, anterior vs non-anterior lesion location is unlikely to impact risk stratification or clinical decision making. Source of Funding: N/A © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e331 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Zoe Blake More articles by this author Katie Merriman More articles by this author Daniel Nemirovsky More articles by this author Jacob Enders More articles by this author Alexander Kenigsberg More articles by this author Mason Belue More articles by this author Enis Yilmaz More articles by this author Tim Phelps More articles by this author Neil Mendhiratta More articles by this author Michael Rothberg More articles by this author Daniel Nethala More articles by this author Antoun Toubaji More articles by this author Maria Merino More articles by this author Bradford Wood More articles by this author Sandeep Gurram More articles by this author Stephanie Harmon More articles by this author Peter Choyke More articles by this author Baris Turkbey More articles by this author Peter Pinto More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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