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- W4360610620 abstract "Abstract It is now easy to perform multiome single-cell analysis, including both RNA and ATAC readouts from the same cell. This enables a closer linkage between the two types of modalities, but it remains an open question what more information can be extracted from this type of data. ATAC-seq is normally only used to assay transcription factor binding to open regions. By reanalyzing several large datasets, and generating an atlas of B cells, we show that telomere accessibility can better pinpoint processes related to cell cycle and chromatin condensation. We provide Telomemore, a tool that can extract telomeric reads, and give examples of new findings it enables. Our new findings will aid in the annotation and analysis of single-cell ATAC or multiome datasets." @default.
- W4360610620 created "2023-03-24" @default.
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- W4360610620 date "2023-03-23" @default.
- W4360610620 modified "2023-09-27" @default.
- W4360610620 title "Telomemore enables single-cell analysis of cell cycle and chromatin condensation" @default.
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- W4360610620 doi "https://doi.org/10.1101/2023.03.19.533267" @default.
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