FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360610685> ?p ?o ?g. }

• W4360610685 abstract "1 Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a poor patient prognosis. Remarkably, PDAC is one of the most aggressive and deadly tumor types and is notorious for its resistance to all types of treatment. PDAC resistance is frequently associated with a wide metabolic rewiring and in particular of the glycolytic branch named Hexosamine Biosynthetic Pathway (HBP). Here we show the effect of the combined treatment between an HBP’s Phosphoglucomutase 3 (PGM3) enzyme inhibitor, named FR054, and erastin (ERA), a recognized ferroptosis inducer, on PDAC cell growth and survival. Noteworthy, the combined treatment applied to PDAC cell lines induces a significant decrease in cell proliferation and a concurrent enhancement of cell death. Furthermore, we show that this combined treatment induces Unfolded Protein Response (UPR), NFE2 Like BZIP Transcription Factor 2 (NRF2) activation, a change in cellular redox state, a greater sensitivity to oxidative stress, a major dependence on glutamine metabolism, and finally ferroptosis cell death. Our study discloses that HBP inhibition enhances, through UPR activation, the ERA effect and therefore might be a novel anticancer mechanism to be exploited as PDAC therapy." @default.
• W4360610685 created "2023-03-24" @default.
• W4360610685 creator A5006330066 @default.
• W4360610685 creator A5010463563 @default.
• W4360610685 creator A5016483673 @default.
• W4360610685 creator A5016940933 @default.
• W4360610685 creator A5036141203 @default.
• W4360610685 creator A5045758778 @default.
• W4360610685 creator A5051624621 @default.
• W4360610685 creator A5065251555 @default.
• W4360610685 date "2023-03-23" @default.
• W4360610685 modified "2023-09-26" @default.
• W4360610685 title "PGM3 inhibition Shows cooperative Effects With Erastin inducing Pancreatic cancer cell death via activation of the Unfolded Protein Response" @default.
• W4360610685 cites W1589007430 @default.
• W4360610685 cites W1965110602 @default.
• W4360610685 cites W1989369955 @default.
• W4360610685 cites W1993204994 @default.
• W4360610685 cites W2000087607 @default.
• W4360610685 cites W2004529113 @default.
• W4360610685 cites W2013966205 @default.
• W4360610685 cites W2016918522 @default.
• W4360610685 cites W2025511820 @default.
• W4360610685 cites W2040114786 @default.
• W4360610685 cites W2057632732 @default.
• W4360610685 cites W2062251192 @default.
• W4360610685 cites W2069269337 @default.
• W4360610685 cites W2074471441 @default.
• W4360610685 cites W2077784911 @default.
• W4360610685 cites W2085933321 @default.
• W4360610685 cites W2102354517 @default.
• W4360610685 cites W2106749088 @default.
• W4360610685 cites W2118394016 @default.
• W4360610685 cites W2119518512 @default.
• W4360610685 cites W2120480388 @default.
• W4360610685 cites W2144827966 @default.
• W4360610685 cites W2149828028 @default.
• W4360610685 cites W2158745183 @default.
• W4360610685 cites W2162853795 @default.
• W4360610685 cites W2163294546 @default.
• W4360610685 cites W2165500341 @default.
• W4360610685 cites W2166063624 @default.
• W4360610685 cites W2169344296 @default.
• W4360610685 cites W2180777157 @default.
• W4360610685 cites W2317877264 @default.
• W4360610685 cites W2567063818 @default.
• W4360610685 cites W2611475096 @default.
• W4360610685 cites W2730056431 @default.
• W4360610685 cites W2735063286 @default.
• W4360610685 cites W2737043580 @default.
• W4360610685 cites W2742971656 @default.
• W4360610685 cites W2747955726 @default.
• W4360610685 cites W2751022555 @default.
• W4360610685 cites W2770709665 @default.
• W4360610685 cites W2778627538 @default.
• W4360610685 cites W2782553457 @default.
• W4360610685 cites W2790068848 @default.
• W4360610685 cites W2794021749 @default.
• W4360610685 cites W2794703348 @default.
• W4360610685 cites W2805054893 @default.
• W4360610685 cites W2807334922 @default.
• W4360610685 cites W2884392492 @default.
• W4360610685 cites W2895610217 @default.
• W4360610685 cites W2905161582 @default.
• W4360610685 cites W2905333028 @default.
• W4360610685 cites W2906319220 @default.
• W4360610685 cites W2907532738 @default.
• W4360610685 cites W2911188335 @default.
• W4360610685 cites W2929359657 @default.
• W4360610685 cites W2945883683 @default.
• W4360610685 cites W2953338815 @default.
• W4360610685 cites W2955544205 @default.
• W4360610685 cites W2973076716 @default.
• W4360610685 cites W2998860042 @default.
• W4360610685 cites W3015020891 @default.
• W4360610685 cites W3015181514 @default.
• W4360610685 cites W3017587954 @default.
• W4360610685 cites W3020916080 @default.
• W4360610685 cites W3021575031 @default.
• W4360610685 cites W3038503389 @default.
• W4360610685 cites W3092757831 @default.
• W4360610685 cites W3095630620 @default.
• W4360610685 cites W3101330565 @default.
• W4360610685 cites W3119508578 @default.
• W4360610685 cites W3132113862 @default.
• W4360610685 cites W3138007187 @default.
• W4360610685 cites W3186955009 @default.
• W4360610685 cites W3187333436 @default.
• W4360610685 cites W3198784050 @default.
• W4360610685 cites W3207977101 @default.
• W4360610685 cites W3209362577 @default.
• W4360610685 cites W3209928606 @default.
• W4360610685 cites W3212334377 @default.
• W4360610685 cites W4200308722 @default.
• W4360610685 cites W4221089883 @default.
• W4360610685 cites W4225302233 @default.
• W4360610685 cites W4248078302 @default.
• W4360610685 cites W4288066861 @default.
• W4360610685 cites W4308579528 @default.
• W4360610685 doi "https://doi.org/10.1101/2023.03.19.533311" @default.
• W4360610685 hasPublicationYear "2023" @default.

• next