FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360611921> ?p ?o ?g. }

• W4360611921 abstract "Abstract Background To understand the molecular mechanisms involved in regulation of DNA methyltransferases (DNMTs) by metformin in non-small cell lung cancer (NSCLC) cells. Methods Expression levels of DNMTs in response to metformin were analyzed in NSCLC cells. MicroRNAs regulating expression of DNMTs at the post-transcriptional level were searched using miRNA-target databases (miRDB and miRTarBase), TCGA RNASeqV2 lung cancer data, and miRNA-seq. Results Metformin dose-dependently downregulated expression of DNMT1 and DNMT3a at the post-transcriptional level and expression of DNMT3b at the transcriptional level in A549 lung cancer cells. Activity of DNMTs was reduced by about 2.6-fold in A549 cells treated with 10 mM metformin for 72 h. miR-148/-152 family members (miR-148a, miR-148b, and miR-152) targeting the 3′UTR of DNMTs were associated with post-transcriptional regulation of DNMTs by metformin. Metformin upregulated expression of miR-148a, miR-148b, and miR-152 in A549 and H1650 cells. Transfection with an miR-148b plasmid or a mimic suppressed expression of DNMT1 and DNMT3b in A549 cells. Transfection with the miR-148a mimic in A549 and H1650 cells decreased the luciferase activity of DNMT1 3′UTR. A combination of metformin and cisplatin synergistically increased expression levels of miR-148/-152 family members but decreased expression of DNMTs in A549 cells. Low expression of miR-148b was associated with poor overall survival (HR = 2.56, 95% CI 1.09—6.47; P = 0.04) but not with recurrence-free survival. Conclusions The present study suggests that metformin inhibits expression of DNMTs by upregulating miR-148/-152 family members in NSCLC cells." @default.
• W4360611921 created "2023-03-24" @default.
• W4360611921 creator A5002055178 @default.
• W4360611921 creator A5007024407 @default.
• W4360611921 creator A5030007653 @default.
• W4360611921 creator A5046938706 @default.
• W4360611921 creator A5078891698 @default.
• W4360611921 creator A5090619385 @default.
• W4360611921 date "2023-03-23" @default.
• W4360611921 modified "2023-09-26" @default.
• W4360611921 title "Metformin regulates expression of DNA methyltransferases through the miR-148/-152 family in non-small lung cancer cells" @default.
• W4360611921 cites W1984860479 @default.
• W4360611921 cites W2004256614 @default.
• W4360611921 cites W2005589635 @default.
• W4360611921 cites W2010927970 @default.
• W4360611921 cites W2021720525 @default.
• W4360611921 cites W2027324111 @default.
• W4360611921 cites W2027802707 @default.
• W4360611921 cites W2032741659 @default.
• W4360611921 cites W2048280970 @default.
• W4360611921 cites W2054742531 @default.
• W4360611921 cites W2058916559 @default.
• W4360611921 cites W2155027651 @default.
• W4360611921 cites W2156440831 @default.
• W4360611921 cites W2235874652 @default.
• W4360611921 cites W2344250613 @default.
• W4360611921 cites W2510697639 @default.
• W4360611921 cites W2511991883 @default.
• W4360611921 cites W2558443380 @default.
• W4360611921 cites W2614226679 @default.
• W4360611921 cites W2738725993 @default.
• W4360611921 cites W2741541139 @default.
• W4360611921 cites W2748432004 @default.
• W4360611921 cites W2752045530 @default.
• W4360611921 cites W2756305519 @default.
• W4360611921 cites W2781525129 @default.
• W4360611921 cites W2794197539 @default.
• W4360611921 cites W2794612153 @default.
• W4360611921 cites W2795054625 @default.
• W4360611921 cites W2816381300 @default.
• W4360611921 cites W2891484388 @default.
• W4360611921 cites W2911900065 @default.
• W4360611921 cites W2993816987 @default.
• W4360611921 cites W3005555059 @default.
• W4360611921 cites W3008482771 @default.
• W4360611921 cites W3037525526 @default.
• W4360611921 cites W3039518440 @default.
• W4360611921 cites W3110945994 @default.
• W4360611921 cites W3176572155 @default.
• W4360611921 cites W4285719527 @default.
• W4360611921 cites W4287477595 @default.
• W4360611921 doi "https://doi.org/10.1186/s13148-023-01466-0" @default.
• W4360611921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36959680" @default.
• W4360611921 hasPublicationYear "2023" @default.
• W4360611921 type Work @default.
• W4360611921 citedByCount "1" @default.
• W4360611921 countsByYear W43606119212023 @default.
• W4360611921 crossrefType "journal-article" @default.
• W4360611921 hasAuthorship W4360611921A5002055178 @default.
• W4360611921 hasAuthorship W4360611921A5007024407 @default.
• W4360611921 hasAuthorship W4360611921A5030007653 @default.
• W4360611921 hasAuthorship W4360611921A5046938706 @default.
• W4360611921 hasAuthorship W4360611921A5078891698 @default.
• W4360611921 hasAuthorship W4360611921A5090619385 @default.
• W4360611921 hasBestOaLocation W43606119211 @default.
• W4360611921 hasConcept C104317684 @default.
• W4360611921 hasConcept C127561419 @default.
• W4360611921 hasConcept C134018914 @default.
• W4360611921 hasConcept C143998085 @default.
• W4360611921 hasConcept C145059251 @default.
• W4360611921 hasConcept C175211621 @default.
• W4360611921 hasConcept C2776256026 @default.
• W4360611921 hasConcept C2777142704 @default.
• W4360611921 hasConcept C2780323712 @default.
• W4360611921 hasConcept C33288867 @default.
• W4360611921 hasConcept C502942594 @default.
• W4360611921 hasConcept C54009773 @default.
• W4360611921 hasConcept C54355233 @default.
• W4360611921 hasConcept C555293320 @default.
• W4360611921 hasConcept C71924100 @default.
• W4360611921 hasConcept C81729549 @default.
• W4360611921 hasConcept C81885089 @default.
• W4360611921 hasConcept C86803240 @default.
• W4360611921 hasConcept C91965660 @default.
• W4360611921 hasConceptScore W4360611921C104317684 @default.
• W4360611921 hasConceptScore W4360611921C127561419 @default.
• W4360611921 hasConceptScore W4360611921C134018914 @default.
• W4360611921 hasConceptScore W4360611921C143998085 @default.
• W4360611921 hasConceptScore W4360611921C145059251 @default.
• W4360611921 hasConceptScore W4360611921C175211621 @default.
• W4360611921 hasConceptScore W4360611921C2776256026 @default.
• W4360611921 hasConceptScore W4360611921C2777142704 @default.
• W4360611921 hasConceptScore W4360611921C2780323712 @default.
• W4360611921 hasConceptScore W4360611921C33288867 @default.
• W4360611921 hasConceptScore W4360611921C502942594 @default.
• W4360611921 hasConceptScore W4360611921C54009773 @default.
• W4360611921 hasConceptScore W4360611921C54355233 @default.
• W4360611921 hasConceptScore W4360611921C555293320 @default.
• W4360611921 hasConceptScore W4360611921C71924100 @default.
• W4360611921 hasConceptScore W4360611921C81729549 @default.

• next